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57-83-0 (Progesterone)



Progesterone Progesterone
Name Progesterone
Formula C21H30O2
MW 314.46
CAS No. 57-83-0
EINECS 200-350-6
Smiles C[[email protected]@]1(CC2)[[email protected]]3([H])[[email protected]](CCC1=CC2=O)([H])[[email protected]@](CC[[email protected]@H]4C(C)=O)([H])[[email protected]]4(C)CC3
Synonyms Progestin; Lutren; Lutein; Flavolutan; Corporin; Luteal hormone; 4-Pregnene-3,20-dione; (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
InChI InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1


Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.

Background Information

Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species. Target: Progesterone receptor Progesterone also known as P4 (pregn-4-ene-3,20-dione) is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. Progesterone belongs to a class of hormones called progestogens, and is the major naturally occurring human progestogen. The route of administration impacts the effect of the drug. Given orally, progesterone has a wide person-to-person variability in absorption andbioavailability while synthetic progestins are rapidly absorbed with a longer half-life than progesterone and maintain stable levels in the blood. Progesterone does not dissolve in water and is poorly absorbed when taken orally unless micronized in oil. Products are often sold as capsules containing micronised progesterone in oil. Progesterone can also be administered through vaginal or rectal suppositories or pessaries, transdermally through a gel or cream, or via injection (though the latter has a short half-life requiring daily administration). Transdermal "natural progesterone" products made with Progesterone USP do not require a prescription. Some of these products also contain "wild yam extract" derived from Dioscorea villosa, but there is no evidence that the human body can convert its active ingredient (diosgenin, the plant steroid that is chemically converted to produce progesterone industrially) into progesterone. ......by MedChemexpress Co., Ltd.
Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. ......by Selleck Chemicals LLC
Progesterone is a critical hormone for the maintenance of pregnancy, menstrual cycle, endometrium and functions with its receptor ......by Target Molecule Corp.
Endogenous progesterone receptor (PR) agonist (EC50 = 0.5 nM). ......by Tocris Bioscience Inc.

Protocol(Only for Reference)

Cell Experiment

Animal Experiment


Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000013447

Storage condition

Store at RT by Tocris Bioscience Inc.


DMSO 22 mg/mL (69 mM); Water <1 mg/mL (<1 mM) by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 22 mg/mL (69.96 mM); Ethanol63 mg/mL (200.34 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
Soluble to 100 mM in DMSO and to 100 mM in ethanol by Tocris Bioscience Inc.

Mechanism and Indication

Signaling Pathways Others
Target Progesterone Receptor
Research Area Cardiovascular Disease

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Progesterone - Launched

Safety Data of Progesterone

Hazard Symbols : Xn
Risk Statements : R40
Safety Statements : S36/37;S45
RTECS : TW0175000
WGKGermany : 3

Spectral Information


Suppliers List


Related Products

Other Forms of 57-83-0

Name CAS No Formula MW

Recommended Compounds in Progesterone Receptor

Name CAS No Formula MW
Etonogestrel 54048-10-1 C22H28O2 324.46
Medroxyprogesterone 520-85-4 C22H32O3 344.49
Norethindrone 68-22-4 C20H26O2 298.42
Altrenogest 850-52-2 C21H26O2 310.43
Medroxyprogesterone (acetate) 71-58-9 C24H34O4 386.52
Dydrogesterone 152-62-5 C21H28O2 312.45
Levonorgestrel 797-63-7 C21H28O2 312.45
Drospirenone 67392-87-4 C24H30O3 366.49
Gestodene 60282-87-3 C21H26O2 310.43
Dienogest 65928-58-7 C20H25NO2 311.42
Tanaproget 304853-42-7 C16H15N3OS 297.37
Mifepristone 84371-65-3 C29H35NO2 429.59
Megestrol (Acetate) 595-33-5 C24H32O4 384.51
Ulipristal (acetate) 126784-99-4 C30H37NO4 475.62
Nestoron 7759-35-5 C23H30O4 370.48
19-Norethindrone acetate 51-98-9 C22H28O3 340.46
Hydroxyprogesterone 68-96-2 C21H30O3 330.46
Ethynodiol diacetate 297-76-7 C24H32O4 384.51
Chlormadinone acetate 302-22-7 C23H29ClO4 404.93
Gestonorone caproate 1253-28-7 C26H38O4 414.58

Recommended Compounds in Same Indication

Name CAS No Formula MW

Route of Synthesis




More Information


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