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57-83-0 (Progesterone)

1

Identification

Progesterone Progesterone
Name Progesterone
Formula C21H30O2
MW 314.46
CAS No. 57-83-0
EINECS 200-350-6
Smiles C[[email protected]@]1(CC2)[[email protected]]3([H])[[email protected]](CCC1=CC2=O)([H])[[email protected]@](CC[[email protected]@H]4C(C)=O)([H])[[email protected]]4(C)CC3
Synonyms Progestin; Lutren; Lutein; Flavolutan; Corporin; Luteal hormone; 4-Pregnene-3,20-dione; (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
InChI InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
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Introduction

Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.

Background Information

Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor. ......by AbMole BioScience
Progesterone, synthesized from cholesterol by the sequential action of desmolase in the mitochondria, plays an important role in brain function as a endogenous progesterone receptor (PR) agonist (EC50 = 0.5 nM). ......by BOC Sciences
Progesterone, along with pregnenolone, is the biosynthetic precursor of all other steroid hormones. Progesterone is hydroxylated by Cytochrome P450 enzymes like CYP3A4 in the liver. ......by BioVision, Inc.,
Progesterone is the biosynthetic precursor of all other steroid hormones. Progesterone induces maturation and secretory activity of the uterine endothelium while suppressing ovulation. Progesterone is implicated in the etiology of breast cancer. Progesterone is an activator of Progesterone Receptor. It is a C-21 steroid hormone. ......by MedKoo Biosciences, Inc.
Progesterone, the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. ......by MedKoo Biosciences, Inc.
Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor. ......by Selleck Chemicals LLC
Progesterone is a critical hormone for the maintenance of pregnancy, menstrual cycle, endometrium and functions with its receptor ......by Target Molecule Corp.
Endogenous progesterone receptor (PR) agonist (EC50 = 0.5 nM). ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000013447

Storage condition

Store at RT by Tocris Bioscience Inc.

Solubility

DMSO 22 mg/mL (69 mM); Water <1 mg/mL (<1 mM) by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 22 mg/mL (69.96 mM); Ethanol63 mg/mL (200.34 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
Soluble to 100 mM in DMSO and to 100 mM in ethanol by Tocris Bioscience Inc.
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Mechanism and Indication

Signaling Pathways Others
Target Progesterone Receptor
Research Area Cardiovascular Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Progesterone - Launched
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Safety Data of Progesterone

Hazard Symbols : Xn
Risk Statements : R40
Safety Statements : S36/37;S45
RTECS : TW0175000
WGKGermany : 3
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Spectral Information

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Suppliers List

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Related Products

Other Forms of 57-83-0

Name CAS No Formula MW

Recommended Compounds in Progesterone Receptor

Name CAS No Formula MW
Etonogestrel 54048-10-1 C22H28O2 324.46
Medroxyprogesterone 520-85-4 C22H32O3 344.49
Norethindrone 68-22-4 C20H26O2 298.42
Altrenogest 850-52-2 C21H26O2 310.43
Medroxyprogesterone (acetate) 71-58-9 C24H34O4 386.52
Dydrogesterone 152-62-5 C21H28O2 312.45
Levonorgestrel 797-63-7 C21H28O2 312.45
Drospirenone 67392-87-4 C24H30O3 366.49
Gestodene 60282-87-3 C21H26O2 310.43
Dienogest 65928-58-7 C20H25NO2 311.42
Tanaproget 304853-42-7 C16H15N3OS 297.37
Mifepristone 84371-65-3 C29H35NO2 429.59
Megestrol (Acetate) 595-33-5 C24H32O4 384.51
Ulipristal (acetate) 126784-99-4 C30H37NO4 475.62
Nestoron 7759-35-5 C23H30O4 370.48
19-Norethindrone acetate 51-98-9 C22H28O3 340.46
Hydroxyprogesterone 68-96-2 C21H30O3 330.46
Ethynodiol (diacetate) 297-76-7 C24H32O4 384.5085
Chlormadinone (acetate) 302-22-7 C23H29ClO4 404.927
Gestonorone Capronate 1253-28-7 C26H38O4 414.57752

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Progesterone

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