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53-06-5 (Cortisone)

1

Identification

Cortisone Cortisone
Name Cortisone
Formula C21H28O5
MW 360.44
CAS No. 53-06-5
EINECS 200-162-4
Smiles C[[email protected]]1(CC2=O)[[email protected]](CC[[email protected]]1(O)C(CO)=O)([H])[[email protected]@](CC3)([H])[[email protected]@]2([H])[[email protected]](CC4)(C)C3=CC4=O
Synonyms 17,21-Dihydroxypregn-4-ene-3,11,20-trione; (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,11(2H,6H)-dione
InChI InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
2

Introduction

Cortisone is a naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE.

Background Information

Cortisone is a synthetic steroid hormone which are widely used for the treatment of in?ammation; a corticosterone analog that has approximately twice the anti-inflammatory potency as corticosterone but much lower Na2+ retention potency. ......by BOC Sciences
Cortisone is a naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. ......by MedKoo Biosciences, Inc.
Cortisone is a pregnane (21-carbon) steroid hormone, one of the main hormones released by the adrenal gland in response to stress.AllergyApproved ......by ProbeChem
Cortisone is a 21-carbon steroid hormone. It is one of the main hormones released by the adrenal gland in response to stress. In chemical structure, it is a corticosteroid closely related to cortisol. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000013319

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

10 mM in DMSO by CHEMSCENE, LLC
10 mM in DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways GPCR/G Protein
Target Glucocorticoid Receptor
Research Area Inflammation/Immunology
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Cortisone - Launched
7

Safety Data of Cortisone

Hazard Symbols : F,T,Xn
Risk Statements : 11-23/24/25-39/23/24/25-63
Safety Statements : 22-24/25-45-36/37-16-7
RTECS : GM9020000
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Aladdin 1g/RMB486();5g/RMB1246() China
Alfa Chemistry USA
Ark Pharm, Inc. USA
BOC Sciences
Beijing Hengye Zhongyuan Chemical Co., Ltd. China
CHEMSCENE, LLC 100mg/USD72();500mg/USD120() USA
Carbosynth Limited 1g/USD70();2g/USD99();5g/USD155();10g/USD245();25g/USD450()
Clearsynth Labs Limited 25mg/USD100();50mg/USD150() India
MedChemexpress Co., Ltd. 100mg/USD72();500mg/USD120() USA
MedKoo Biosciences, Inc. USA
ProbeChem
Santa Cruz Biotechnology, Inc. 5g/USD156() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD72();500mg/USD120() China
Sigma-Aldrich, Inc. 250mg/USD22();1g/USD51();5g/USD164() USA
Target Molecule Corp. 5mg/USD24();10mg/USD43();20mg/USD74();100mg/USD168();250mg/USD298() USA
Tianjin Heowns Biochemical Technology Co., Ltd. 1g/RMB138() China
Tokyo Chemical Industry Co., Ltd. 1g/USD27();10g/USD133() Japan
Toronto Research Chemicals Inc. 1g/USD50();2g/USD90();5g/USD125();10g/USD235();25g/USD44050() Canada
Xiangyang Jinsheng Pharmaceutical Co., Ltd. China
10

Related Products

Other Forms of 53-06-5

Name CAS No Formula MW
Cortisone (acetate) 50-04-4 C23H30O6 402.48

Recommended Compounds in Glucocorticoid Receptor

Name CAS No Formula MW
(20S)-Protopanaxatriol 34080-08-5 C30H52O4 476.73
Prednisolone (disodium phosphate) 125-02-0 C21H27Na2O8P 484.39
Triamcinolone (acetonide) 76-25-5 C24H31FO6 434.5
Ciclesonide 126544-47-6 C32H44O7 540.69
Fluocinonide 356-12-7 C26H32F2O7 494.52
Fluocinolone (Acetonide) 67-73-2 C24H30F2O6 452.49
Triamcinolone 124-94-7 C21H27FO6 394.43
Methylprednisolone 83-43-2 C22H30O5 374.47
Desonide 638-94-8 C24H32O6 416.51
Meprednisone 1247-42-3 C22H28O5 372.45
Prednisone 53-03-2 C21H26O5 358.43
Dexamethasone (acetate) 1177-87-3 C24H31FO6 434.5
Fluticasone (propionate) 80474-14-2 C25H31F3O5S 500.57
Betamethasone (hydrochloride) 956901-32-9 C22H30ClFO5 428.92
Hydrocortisone 50-23-7 C21H30O5 362.46
Prednisolone 50-24-8 C21H28O5 360.44
Cortisone (acetate) 50-04-4 C23H30O6 402.48
AL 082D06 256925-03-8 C23H24ClN3O2 409.91
Mometasone furoate 83919-23-7 C32H32Cl2O8 615.5
Mifepristone 84371-65-3 C29H35NO2 429.59

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

Protocol Reference

13

More Information

Cortisone

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