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65928-58-7 (Dienogest)



Dienogest Dienogest
Name Dienogest
Formula C20H25NO2
MW 311.42
CAS No. 65928-58-7
Smiles C[[email protected]]([[email protected]@](CC#N)(O)CC1)(CC2)[[email protected]]1([H])[[email protected]@](CC3)([H])C2=C(CC4)C3=CC4=O
Synonyms 2-((8S,13S,14S,17R)-17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)acetonitrile
InChI InChI=1S/C20H25NO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h12,17-18,23H,2-10H2,1H3/t17-,18+,19+,20-/m1/s1


Dienogest(STS-557) is a specific progesterone receptor agonist with potent oral endometrial activity and is used in the treatment of endometriosis.

Background Information

Dienogest(STS-557) is a specific progesterone receptor agonist with potent oral endometrial activity and is used in the treatment of endometriosis. Target: progesterone receptor agonist Dienogest is an orally active synthetic progesterone (or progestin). It is available for use as an oral contraceptive in combination with ethinylestradiol. It has antiandrogenic activity and as a result can improve androgenic symptoms. It is a non-ethinylated progestin which is structurally related to testosterone [1]. Complete sperm suppression was observed in rats sacrificed either 60 or 90 days after dienogest (DNG)+ testosterone undecanoate (TU) administration, for two injections at 45-day interval. The neutral α-glucosidase activity in these treated rats remained in the normal range. Germ cell loss due to apoptosis was frequently observed both after 60 or 90 days of combination treatment. Significant decline in serum gonadotropin and testosterone, both serum and intratesticular levels, were observed in the treated rats. Following stoppage of treatment (given at 45-day interval) after two (0 and 45 days) or three injections (0, 45 and 90 days), complete restoration of spermatogenesis was observed by 120 and 165 days, respectively [2]. Clinical indications: Adenomyosis; Endometriosis FDA Approved Date: 1995 Toxicity: weight gain; increased blood pressure; breast tenderness and nausea ......by MedChemexpress Co., Ltd.
Dienogest is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis. ......by Selleck Chemicals LLC
Dienogest is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis. ......by Target Molecule Corp.

Protocol(Only for Reference)

Cell Experiment

Animal Experiment


Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000013217

Storage condition


DMSO by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 62 mg/mL (199.08 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC

Mechanism and Indication

Signaling Pathways Autophagy Others
Target Progesterone Receptor Autophagy
Research Area Endocrinology

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Dienogest - Launched

Safety Data of Dienogest


Spectral Information


Suppliers List

Company Price and Availability Country/Region
Apichem Chemical Technology Co., Ltd. China
Jinan Chenghui-Shuangda Chemical Co., Ltd. China
MedChemexpress Co., Ltd. 10mg/USD80(In stock);50mg/USD288(In stock);100mg/USD544(In stock) USA
Selleck Chemicals LLC 10mg/USD120(In stock);10mM/1mLIn DMSO/USD160(In stock);25mg/USD270(In stock);100mg/USD770(In stock) USA
Shandong Chengchuang Pharmaceutical Technology Development Co., Ltd. China
Shanghai Everchem Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD80(Get quote);50mg/USD288(Get quote);100mg/USD544(Get quote) China
Target Molecule Corp. 10mg/USD120();50mg/USD190();100mg/USD339() USA
Zhejiang Xianju Xianle Pharmaceutical Co., Ltd. China

Related Products

Other Forms of 65928-58-7

Name CAS No Formula MW

Recommended Compounds in Progesterone Receptor Autophagy

Name CAS No Formula MW
Etonogestrel 54048-10-1 C22H28O2 324.46
Medroxyprogesterone 520-85-4 C22H32O3 344.49
Norethindrone 68-22-4 C20H26O2 298.42
Altrenogest 850-52-2 C21H26O2 310.43
Medroxyprogesterone (acetate) 71-58-9 C24H34O4 386.52
Dydrogesterone 152-62-5 C21H28O2 312.45
Levonorgestrel 797-63-7 C21H28O2 312.45
Drospirenone 67392-87-4 C24H30O3 366.49
Gestodene 60282-87-3 C21H26O2 310.43
Progesterone 57-83-0 C21H30O2 314.46
Tanaproget 304853-42-7 C16H15N3OS 297.37
Mifepristone 84371-65-3 C29H35NO2 429.59
Megestrol (Acetate) 595-33-5 C24H32O4 384.51
Ulipristal (acetate) 126784-99-4 C30H37NO4 475.62
Nestoron 7759-35-5 C23H30O4 370.48
19-Norethindrone acetate 51-98-9 C22H28O3 340.46
Hydroxyprogesterone 68-96-2 C21H30O3 330.46
Ethynodiol diacetate 297-76-7 C24H32O4 384.51
Chlormadinone acetate 302-22-7 C23H29ClO4 404.93
Gestonorone caproate 1253-28-7 C26H38O4 414.58

Recommended Compounds in Same Indication

Name CAS No Formula MW

Route of Synthesis




More Information


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