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55079-83-9 (Acitretin)

1

Identification

Acitretin Acitretin
Name Acitretin
Formula C21H26O3
MW 326.43
CAS No. 55079-83-9
EINECS 259-474-4
Smiles CC(/C=C/C(C(C)=CC(OC)=C1C)=C1C)=CC=CC(C)=CC(O)=O
Synonyms Ro 10-1670;Soriatane; (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
InChI InChI=1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+
2

Introduction

Acitretin(Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis. Target: RAR/RXR Acitretin is a second-generation, systemic retinoid that has been approved for the treatment of psoriasis since 1997.

Background Information

Acitretin is a second generation retinoid and is typically used for psoriasis. ......by AdooQ BioScience, LLC
Acitretin is a second generation retinoid used for psoriasis. ......by BOC Sciences
Acitretin is an oral synthetic retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate (sc-205689). It has demonstrated an ability to suppress the development of chemically-induced epithelial tumors, as well as squamous cell carcinoma. Acitretin has potential antineoplastic, chemopreventive, anti-psoratic, and embryotoxic properties. Acitretin activates nuclear retinoic acid receptors (RAR), resulting in induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. This agent may also inhibit tumor angiogenesis. ......by MedKoo Biosciences, Inc.
Acitretin is a second generation retinoid used for psoriasis. ......by Selleck Chemicals LLC
An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of ETRETINATE with the advantage of a much shorter half-life when compared with etretinate. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000013137

Storage condition

Solubility

DMSO 20 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 20 mg/mL (61.26 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways Metabolic Enzyme/Protease
Target RAR/RXR
Research Area Inflammation/Immunology
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Acitretin - Launched
7

Safety Data of Acitretin

Hazard Symbols : T,N
Risk Statements : 61-36/38-50/53
Safety Statements : 53-26-45-60-61-37/39
RTECS : RA8460000
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 100mg/USD154();200mg/USD252() USA
Cayman Chemical Company USA
Chongqing Huapont Pharm. Co., Ltd. China
Hande Industry & Trade Holdings Ltd. China
Hangzhou Best Chemical Co., Ltd. China
Hangzhou Deli Chemical Co., Ltd. China
Hangzhou Fst Pharmaceutical Co., Ltd. China
MedChemexpress Co., Ltd. 100mg/USD154();200mg/USD252() USA
MedKoo Biosciences, Inc. USA
Nectar Industrial Co., Ltd. China
Nexchem Pharmaceutical Co., Ltd. China
Selleck Chemicals LLC 25mg/USD70(In stock);50mg/USD120(In stock);100mg/USD210(In stock);10mM/1mLIn DMSO/USD420(In stock);500mg/USD670(In stock) USA
Shanghai Chely Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD154();200mg/USD252() China
Shangyu Zhebang Pharmaceutical Co., Ltd. China
Taizhou Hengfeng Pharmaceutical & Chemical Co., Ltd. China
Target Molecule Corp. 2mg/USD20();5mg/USD40();10mg/USD78();25mg/USD140();50mg/USD252() USA
Zhejiang Wonderful Pharma & Chem Co., Ltd. China
10

Related Products

Other Forms of 55079-83-9

Name CAS No Formula MW
Acitretin (sodium) 925701-88-8 C21H25NaO3 348.41

Recommended Compounds in RAR/RXR

Name CAS No Formula MW
AGN 205728 859498-05-8 C29H27NO3 437.53
AGN 196996 958295-17-5 C24H20BrNO5 482.32
AGN 194310 229961-45-9 C28H24O2S 424.55
Acitretin (sodium) 925701-88-8 C21H25NaO3 348.41
Adapalene (sodium salt) 911110-93-5 C28H27NaO3 434.5
Adapalene 106685-40-9 C28H28O3 412.52
TTNPB 71441-28-6 C24H28O2 348.48
Magnolol 528-43-8 C18H18O2 266.33
Tazarotene 118292-40-3 C21H21NO2S 351.46
Fenretinide 65646-68-6 C26H33NO2 391.55
LG 100268 153559-76-3 C24H29NO2 363.49
Isotretinoin 4759-48-2 C20H28O2 300.44
Palovarotene 410528-02-8 C27H30N2O2 414.54
Retinoic acid 302-79-4 C20H28O2 300.44
AM580 102121-60-8 C22H25NO3 351.44
(R)-Flurbiprofen 51543-40-9 C15H13FO2 244.2609
Tamibarotene 94497-51-5 C22H25NO3 351.44
Bexarotene 153559-49-0 C24H28O2 348.48
AGN 195183 367273-07-2 C22H22ClF2NO4 437.86
AR7 80306-38-3 C15H12ClNO 0.0

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Acitretin

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