• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

1421373-62-7 (Mutant EGFR inhibitor)

1

Identification

Mutant EGFR inhibitor Mutant EGFR inhibitor
Name Mutant EGFR inhibitor
Formula C27H30ClN7O2
MW 520.03
CAS No. 1421373-62-7
EINECS
Smiles C=CC(NC1=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C)=O
Synonyms N-(5-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
InChI InChI=1S/C27H30ClN7O2/c1-6-25(36)31-21-13-22(24(37-5)14-23(21)35(4)12-11-34(2)3)32-27-30-16-19(28)26(33-27)18-15-29-20-10-8-7-9-17(18)20/h6-10,13-16,29H,1,11-12H2,2-5H3,(H,31,36)(H,30,32,33)
2

Introduction

Mutant EGFR inhibitor is a selective and potent Mutated EGFR inhibitor(L858R activating mutant, the Exonl9 deletion activating mutant and the T790M resistance mutant). IC50 value: Target: Mutated EGFR Preparation of 2-(2,4,5-substituted-anilino)pyrimidine derivatives as EGFR modulators useful for treating cancer. By Butterworth, Sam; Finlay, Maurice Raymond Verschoyle; Ward, Richard Andrew; Kadambar, Vasantha Krishna; Chandrashekar, Reddy C.; Murugan, Andiappan; Redfearn, Heather Marie From PCT Int.

Background Information

Mutant EGFR inhibitor is a potent and selective mutant EGFR inhibitor extracted from patent WO 2013014448 A1; inhibits EGFRL858R, EGFRExon 19 deletion and EGFRT790M. ......by MedChemexpress Co., Ltd.
MDK3627, also known as Mutant EGFR inhibitor, is a selective and potent Mutated EGFR inhibitor(L858R activating mutant, ......by MedKoo Biosciences, Inc.
Mutant EGFR inhibitor is a selective and potent Mutated EGFR inhibitor(L858R activating mutant, the Exonl9 deletion activating mutant and the T790M resistance mutant). ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000013136

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways JAK/STAT Signaling Protein Tyrosine Kinase/RTK
Target EGFR
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Mutant EGFR inhibitor - Not Found
Mutant EGFR inhibitor - No Development Reported
7

Safety Data of Mutant EGFR inhibitor

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD420();10mg/USD600() USA
MedChemexpress Co., Ltd. 5mg/USD420();10mg/USD600() USA
MedKoo Biosciences, Inc. USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD420();10mg/USD600() China
Sigma-Aldrich, Inc. USA
Target Molecule Corp. 2mg/USD234();5mg/USD365();10mg/USD560();25mg/USD862();50mg/USD1188() USA
10

Related Products

Other Forms of 1421373-62-7

Name CAS No Formula MW

Recommended Compounds in EGFR

Name CAS No Formula MW
Ginsenoside Rh2 78214-33-2 C36H62O8 622.87
Mutated EGFR-IN-1 1421372-66-8 C25H31N7O 445.56
AZD-9291 (mesylate) 1421373-66-1 C29H37N7O5S 595.71
AZD-9291 1421373-65-0 C28H33N7O2 499.61
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 333.77
WHI-P180 211555-08-7 C16H15N3O3 297.31
Gefitinib (hydrochloride) 184475-55-6 C22H25Cl2FN4O3 483.36
Erlotinib (mesylate) 248594-19-6 C23H27N3O7S 489.54
BGB-102 807640-87-5 C22H25BrN4O2 457.36
Poziotinib 1092364-38-9 C23H21Cl2FN4O3 491.34
CO-1686 (hydrobromide) 1446700-26-0 C27H29BrF3N7O3 636.46
CO-1686 1374640-70-6 C27H28F3N7O3 555.55
CNX-2006 1375465-09-0 C26H27F4N7O2 545.53
PD168393 194423-15-9 C17H13BrN4O 369.2153
AG 18 118409-57-7 C10H6N2O2 186.17
Afatinib (dimaleate) 850140-73-7 C32H33ClFN5O11 718.08
Chrysophanol 481-74-3 C15H10O4 254.2375
AG-1478 153436-53-4 C16H14ClN3O2 315.75
Mubritinib 366017-09-6 C25H23F3N4O2 468.47
AST-1306 (TsOH) 1050500-29-2 C31H26ClFN4O5S 621.08

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Mutant EGFR inhibitor

Tags: buy 1421373-62-7 IC50 | 1421373-62-7 price | 1421373-62-7 cost | 1421373-62-7 solubility | 1421373-62-7 purchase | 1421373-62-7 manufacturer | 1421373-62-7 research buy | 1421373-62-7 order | 1421373-62-7 MSDS | 1421373-62-7 chemical structure | 1421373-62-7 Storage condition | 1421373-62-7 molecular weight | 1421373-62-7 mw | 1421373-62-7 datasheet | 1421373-62-7 supplier | 1421373-62-7 cell line | 1421373-62-7 NMR | 1421373-62-7 MS | 1421373-62-7 IR | 1421373-62-7 solubility | 1421373-62-7 Safe information | 1421373-62-7 Qc and Spectral Information | 1421373-62-7 Clinical Information | 1421373-62-7 Clinical Trial | 1421373-62-7 Route of Synthesis | 1421373-62-7 storage condition | 1421373-62-7 diseases and conditions | 1421373-62-7 flash point | 1421373-62-7 boiling point | 1421373-62-7 melting point | 1421373-62-7 storage condition | 1421373-62-7 brand