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60282-87-3 (Gestodene)



Gestodene Gestodene
Name Gestodene
Formula C21H26O2
MW 310.43
CAS No. 60282-87-3
EINECS 262-145-8
Smiles CC[[email protected]@]1([[email protected]]2(O)C#C)[[email protected]](C=C2)([H])[[email protected]@](CCC3=CC4=O)([H])[[email protected]]([[email protected]@]3([H])CC4)([H])CC1
Synonyms Gestinol;SHB 331;WL 70; (8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-6,7,8,9,10,11,12,13,14,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
InChI InChI=1S/C21H26O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,10,12-13,16-19,23H,3,5-9,11H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1


Gestodene(SHB 331;WL 70) is a progestogen hormonal contraceptive. Target: Estrogen Receptor/ERR Gestodene is androgenically neutral, meaning that contraceptive pills containing gestodene do not exhibit the androgenic side effects (e.g.

Background Information

Gestodene(SHB 331;WL 70) is a progestogen hormonal contraceptive. Target: Estrogen Receptor/ERR Gestodene is androgenically neutral, meaning that contraceptive pills containing gestodene do not exhibit the androgenic side effects (e.g. acne, hirsutism, weight gain) often associated with second-generation contraceptive pills, such as those containing levonorgestrel. When 40 micrograms of gestodene was taken, six out of seven women did not ovulate, and one out of seven had a cycle with luteal insufficiency. These data indicate that 40 micrograms of gestodene is the borderline dose for inhibition of ovulation. A combination of 75 micrograms gestodene with 30 micrograms ethinyl estradiol was found to inhibit ovulation in ten subjects, and no follicular maturation was noted [1]. gestodene bound with high affinity to the progesterone receptor, as did other synthetic and natural progestogens. However, gestodene did not bind to the estradiol receptor. The relative binding affinities of all tested synthetic and natural ligands showed no organ-specific differences and no differences between neoplastically transformed and normal tissues [2]. Clinical indications: Female contraception ......by MedChemexpress Co., Ltd.
Gestodene is a progestogen hormonal contraceptive. ......by Selleck Chemicals LLC
Estrogens and progestins are female hormones. They are produced by the body and are necessary for the normal sexual development of the female and for the regulation of the menstrual cycle during the childbearing years. Gestodene is a progestogen hormonal contraceptive. ......by Target Molecule Corp.

Protocol(Only for Reference)

Cell Experiment

Animal Experiment


Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000013130

Storage condition


DMSO 62 mg/mL; Water <1 mg/mL; Ethanol 7 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 62 mg/mL (199.72 mM); Ethanol8 mg/mL (25.77 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC

Mechanism and Indication

Signaling Pathways Others
Target Progesterone Receptor
Research Area Endocrinology

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Gestodene - Launched

Safety Data of Gestodene

Hazard Symbols : Xn
Risk Statements : 62
Safety Statements : 36/37

Spectral Information


Suppliers List

Company Price and Availability Country/Region
Agile Mfg. Chemical Co., Ltd. China
Hande Pharma Limited China
Hangzhou Deli Chemical Co., Ltd. China
MedChemexpress Co., Ltd. 10mg/USD55(In stock);50mg/USD185(In stock);100mg/USD305(In stock) USA
Nectar Industrial Co., Ltd. China
Selleck Chemicals LLC 10mg/USD110(In stock);10mM/1mLIn DMSO/USD140(In stock);25mg/USD170(In stock);100mg/USD470(In stock) USA
Shanghai Desano Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD55(Get quote);50mg/USD185(Get quote);100mg/USD305(Get quote) China
Sinobond Imp. & Exp. (Ningbo) Co., Ltd. China
Target Molecule Corp. 2mg/USD36();10mg/USD75();25mg/USD143() USA
Zhangjiagang Sunrise Fine Chemical Co., Ltd. China

Related Products

Other Forms of 60282-87-3

Name CAS No Formula MW

Recommended Compounds in Progesterone Receptor

Name CAS No Formula MW
Etonogestrel 54048-10-1 C22H28O2 324.46
Medroxyprogesterone 520-85-4 C22H32O3 344.49
Norethindrone 68-22-4 C20H26O2 298.42
Altrenogest 850-52-2 C21H26O2 310.43
Medroxyprogesterone (acetate) 71-58-9 C24H34O4 386.52
Dydrogesterone 152-62-5 C21H28O2 312.45
Levonorgestrel 797-63-7 C21H28O2 312.45
Drospirenone 67392-87-4 C24H30O3 366.49
Dienogest 65928-58-7 C20H25NO2 311.42
Progesterone 57-83-0 C21H30O2 314.46
Tanaproget 304853-42-7 C16H15N3OS 297.37
Mifepristone 84371-65-3 C29H35NO2 429.59
Megestrol (Acetate) 595-33-5 C24H32O4 384.51
Ulipristal (acetate) 126784-99-4 C30H37NO4 475.62
Nestoron 7759-35-5 C23H30O4 370.48
19-Norethindrone acetate 51-98-9 C22H28O3 340.46
Hydroxyprogesterone 68-96-2 C21H30O3 330.46
Ethynodiol diacetate 297-76-7 C24H32O4 384.51
Chlormadinone acetate 302-22-7 C23H29ClO4 404.93
Gestonorone caproate 1253-28-7 C26H38O4 414.58

Recommended Compounds in Same Indication

Name CAS No Formula MW

Route of Synthesis




More Information


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