• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

67392-87-4 (Drospirenone)

1

Identification

Drospirenone Drospirenone
Name Drospirenone
Formula C24H30O3
MW 366.49
CAS No. 67392-87-4
EINECS 266-679-2
Smiles C[[email protected]@]12[[email protected]](OC3=O)(CC3)[[email protected]](C4)([H])[[email protected]]4([H])[[email protected]@]1([H])[[email protected]@]([[email protected]]5([H])[[email protected]@]6([H])C5)([H])[[email protected]]([[email protected]](CC7)(C)C6=CC7=O)([H])CC2
Synonyms 6b,7b:15b,16b-Dimethylen-3-oxo-17a-pregn-4-ene-21,17-carbolactone; Dihydrospirorenone; (2'S,4aR,4bS,6aS,7aS,8aS,8bS,8cR,8dR,9aR)-4a,6a-dimethyl-4,4a,4b,5,6,6a,7a,8,8a,8b,8c,8d,9,9a-tetradecahydro-3'H-spiro[cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-7,2'-furan]-2,5'(3H,4'H)-dione
InChI InChI=1S/C24H30O3/c1-22-6-3-12(25)9-17(22)13-10-14(13)20-16(22)4-7-23(2)21(20)15-11-18(15)24(23)8-5-19(26)27-24/h9,13-16,18,20-21H,3-8,10-11H2,1-2H3/t13-,14+,15-,16+,18+,20-,21+,22-,23+,24+/m1/s1
2

Introduction

Drospirenone(Dihydrospirorenone) is a synthetic progestin that is an analog to spironolactone. Target: Progesterone Receptor Drospirenone is a novel progestin under clinical development that is similar to the natural hormone progesterone, combining potent progestogenic with antimineralocorticoid and antiandrogenic activities.

Background Information

Drospirenone is a synthetic hormone used in birth control pills and postmenopausal hormone replacement therapy pills. ......by BOC Sciences
Drospirenone is a synthetic progestin that is an analog to spironolactone. ......by Selleck Chemicals LLC
Drospirenone is a synthetic progestin that is an analog to spironolactone. It is found in a number of birth control formulations. Drospirenone differs from other synthetic progestins in that its pharmacological profile in preclinical studies shows it to be closer to the natural progesterone. As such it has anti-mineralocorticoid properties, counteracts the estrogen-stimulated activity of the renin-angiotensin-aldosterone system, and is not androgenic. It was shown in animal studies that drospirenone exhibits antiandrogenic activity judging from accessory sex gland growth in castrated, androgen-treated, juvenile rats. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000013129

Storage condition

Solubility

DMSO 72 mg/mL; Water <1 mg/mL; Ethanol 11 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 73 mg/mL (199.18 mM); Ethanol11 mg/mL (30.01 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways Others
Target Progesterone Receptor
Research Area Endocrinology
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Drospirenone - Launched
7

Safety Data of Drospirenone

Hazard Symbols : T
Risk Statements : 60
Safety Statements : 36/37
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Agile Mfg. Chemical Co., Ltd. China
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD50();50mg/USD150() USA
Hande Industry & Trade Holdings Ltd. China
Hangzhou Deli Chemical Co., Ltd. China
Hangzhou Fst Pharmaceutical Co., Ltd. China
Hubei Gedian Humanwell Pharmaceutical Co., Ltd. China
MedChemexpress Co., Ltd. 10mg/USD50();50mg/USD150() USA
Novelab Ltd. China
Selleck Chemicals LLC 10mg/USD110(In stock);10mM/1mLIn DMSO/USD140(In stock);25mg/USD210(In stock);100mg/USD670(In stock);500mg/USD3250(In stock) USA
Shanghai Desano Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD50();50mg/USD150() China
Sinobond Imp. & Exp. (Ningbo) Co., Ltd. China
Spec-Chem Industry Inc. China
Target Molecule Corp. 2mg/USD36();10mg/USD96();25mg/USD158();100mg/USD288() USA
Zhejiang Xianju Junye Pharmaceutical Co., Ltd. China
10

Related Products

Other Forms of 67392-87-4

Name CAS No Formula MW

Recommended Compounds in Progesterone Receptor

Name CAS No Formula MW
Etonogestrel 54048-10-1 C22H28O2 324.46
Medroxyprogesterone 520-85-4 C22H32O3 344.49
Norethindrone 68-22-4 C20H26O2 298.42
Altrenogest 850-52-2 C21H26O2 310.43
Medroxyprogesterone (acetate) 71-58-9 C24H34O4 386.52
Dydrogesterone 152-62-5 C21H28O2 312.45
Levonorgestrel 797-63-7 C21H28O2 312.45
Gestodene 60282-87-3 C21H26O2 310.43
Dienogest 65928-58-7 C20H25NO2 311.42
Progesterone 57-83-0 C21H30O2 314.46
Tanaproget 304853-42-7 C16H15N3OS 297.37
Mifepristone 84371-65-3 C29H35NO2 429.59
Megestrol (Acetate) 595-33-5 C24H32O4 384.51
Ulipristal (acetate) 126784-99-4 C30H37NO4 475.62
Nestoron 7759-35-5 C23H30O4 370.48
19-Norethindrone acetate 51-98-9 C22H28O3 340.46
Hydroxyprogesterone 68-96-2 C21H30O3 330.46
Ethynodiol (diacetate) 297-76-7 C24H32O4 384.5085
Chlormadinone (acetate) 302-22-7 C23H29ClO4 404.927
Gestonorone Capronate 1253-28-7 C26H38O4 414.57752

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Drospirenone

Tags: buy 67392-87-4 IC50 | 67392-87-4 price | 67392-87-4 cost | 67392-87-4 solubility | 67392-87-4 purchase | 67392-87-4 manufacturer | 67392-87-4 research buy | 67392-87-4 order | 67392-87-4 MSDS | 67392-87-4 chemical structure | 67392-87-4 Storage condition | 67392-87-4 molecular weight | 67392-87-4 mw | 67392-87-4 datasheet | 67392-87-4 supplier | 67392-87-4 cell line | 67392-87-4 NMR | 67392-87-4 MS | 67392-87-4 IR | 67392-87-4 solubility | 67392-87-4 Safe information | 67392-87-4 Qc and Spectral Information | 67392-87-4 Clinical Information | 67392-87-4 Clinical Trial | 67392-87-4 Route of Synthesis | 67392-87-4 storage condition | 67392-87-4 diseases and conditions | 67392-87-4 flash point | 67392-87-4 boiling point | 67392-87-4 melting point | 67392-87-4 storage condition | 67392-87-4 brand