• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

1159813-51-0 (Risedronate (free base))

1

Identification

Risedronate (free base) Risedronate (free base)
Name Risedronate (free base)
Formula C7H10NNaO7P2
MW 305.0941
CAS No. 1159813-51-0
EINECS
Smiles OC(CC1=CN=CC=C1)(P(O)(O)=O)P(O[Na])(O)=O
Synonyms
InChI InChI=1S/C7H11NO7P2.Na/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6;/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15);/q;+1/p-1
2

Introduction

Background Information

Risedronate Sodium is a bisphosphonate used to strengthen bone, treat or prevent osteoporosis, and treat Paget's disease of bone. ......by BOC Sciences
Risedronate sodium is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption. Target: Risedronate sodium, which was promoted in Croatia a few months ago, is the latest (III) generation of bisphosphonates, the most efficient anti-resorption drugs that inhibit osteoclast-mediated bone resorption and change the bone metabolism. Risedronate sodium is hence the first line of bisphosphonates for the reduction of vertebral and non-vertebral fracture risks in postmenopausal women with osteoporosis or those with a high risk of osteoporosis. It also efficiently prevents bone loss or improves bone density in men and women on a long-term corticosteroid therapy [1]. The administration of 20 and 25 mg/kg risedronate sodium for 4 days led to decreases of parasitemia of 68.9% and 83.6%, respectively. On the seventh day of treatment the inhibitions were 63% and 88.9% with 20 and 25 mg/kg, respectively. After recovering the parasitemia, a dose-response curve was obtained for estimating the ID50 (dose causing 50% inhibition), equivalent to 17 ± 1.8 mg/kg after 7 days of treatment. Four days after the interruption of treatment (11 days postinfection), the parasitemias of the groups treated with 10, 15, 20, and 25 mg/kg/day were 15.3%, 15.9%, 15.2%, and 5.7%, respectively. Conversely, the group that received PBS presented parasitemia of 25.6%. Among the groups treated with risedronate sodium, only the animals that received 25 mg/kg had a significant inhibition of 77.8% (see Table S1 in the supplemental material), demonstrating that even after treatment discontinuation, the parasitemia of the animals remained low in relation to that of the controls [2]. Clinical indications: Bone resorption; Male osteoporosis; Osteogenesis imperfecta; Osteoporosis; Pagets bone disease Toxicity: abdominal pain; anxiety, back pain; belching, bladder irritation; bone disorders and pain; bronchitis; bursitis; cataracts; chest pain; colitis; constipation; depression; diarrhea; difficulty breathing ......by MedChemexpress Co., Ltd.
Risedronate Sodium, a nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption and modulates bone metabolism, used in the treatment of osteoporosis. ......by Selleck Chemicals LLC
Risedronate Sodium, a nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption and modulates bone metabolism, used in the treatment of osteoporosis. ......by Target Molecule Corp.
Orally active biphosphonate that inhibits farnesyl diphosphate (FPP) synthase. Exhibits antiproliferative and proapoptotic activity in numerous tumor cell lines and inhibits osteoclast-mediated bone reabsorption in vivo. ......by Tocris Bioscience Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000013079

Storage condition

Store at RT by Tocris Bioscience Inc.

Solubility

DMSO <1 mg/mL; Water 2 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro Water 2 mg/mL (6.55 mM); DMSO<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
Soluble to 10 mM in water by Tocris Bioscience Inc.
5

Mechanism and Indication

Signaling Pathways Others
Target Others
Research Area Others
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Risedronate (free base) - Launched
7

Safety Data of Risedronate (free base)

8

Spectral Information

9

Suppliers List

10

Related Products

Other Forms of 1159813-51-0

Name CAS No Formula MW
Risedronate (free base) 1159813-51-0 C7H10NNaO7P2 305.09

Recommended Compounds in Others

Name CAS No Formula MW
(R)-(+)-Etomoxir (sodium salt) 828934-41-4 C15H18ClNaO4 320.74
Dictamine 484-29-7 C12H9NO2 199.21
3,3',5-Triiodo-L-thyronine (sodium) 55-06-1 C15H11I3NNaO4 672.9553
Fabomotizole (hydrochloride) 173352-39-1 C15H22ClN3O2S 343.8721
FPH2 957485-64-2 C14H16ClN5O2S 353.83
α-Tocopherol (phosphate) 38976-17-9 C29H51O5P 510.69
BAMB-4 891025-25-5 C15H12N2O2 252.27
LDN-27219 312946-37-5 C20H16N4O2S2 408.5
ISO-1 478336-92-4 C12H13NO4 235.24
Aurothioglucose 12192-57-3 C6H11AuO5S 392.18
Oxybenzone 131-57-7 C14H12O3 228.24
ITX3 347323-96-0 C22H17N3OS 371.45
Cardiogreen 3599-32-4 C43H47N2NaO6S2 774.96
Skp2 Inhibitor C1 432001-69-9 C18H13BrN2O4S2 465.34
INH1 313553-47-8 C18H16N2OS 308.4
PF6-AM 1268491-69-5 C33H31BO12 630.4
XEN445 1515856-92-4 C18H17F3N2O3 366.33
Disperse Blue 148 52239-04-0 C19H19N5O4S 413.45026
Solvent Blue 35 17354-14-2 C22H26N2O2 350.454
CID-797718 370586-05-3 C12H11NO3 217.2206

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Risedronate (free base)

Tags: buy 1159813-51-0 IC50 | 1159813-51-0 price | 1159813-51-0 cost | 1159813-51-0 solubility | 1159813-51-0 purchase | 1159813-51-0 manufacturer | 1159813-51-0 research buy | 1159813-51-0 order | 1159813-51-0 MSDS | 1159813-51-0 chemical structure | 1159813-51-0 Storage condition | 1159813-51-0 molecular weight | 1159813-51-0 mw | 1159813-51-0 datasheet | 1159813-51-0 supplier | 1159813-51-0 cell line | 1159813-51-0 NMR | 1159813-51-0 MS | 1159813-51-0 IR | 1159813-51-0 solubility | 1159813-51-0 Safe information | 1159813-51-0 Qc and Spectral Information | 1159813-51-0 Clinical Information | 1159813-51-0 Clinical Trial | 1159813-51-0 Route of Synthesis | 1159813-51-0 storage condition | 1159813-51-0 diseases and conditions | 1159813-51-0 flash point | 1159813-51-0 boiling point | 1159813-51-0 melting point | 1159813-51-0 storage condition | 1159813-51-0 brand