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68291-98-5 (Zonisamide (sodium))

1

Identification

Zonisamide (sodium) Zonisamide (sodium)
Name Zonisamide (sodium)
Formula C8H7N2NaO3S
MW 234.21
CAS No. 68291-98-5
EINECS
Smiles O=S(CC1=NOC2=C1C=CC=C2)(N[Na])=O
Synonyms AD 810 sodium;CI 912 sodium; sodium ((benzo[d]isoxazol-3-ylmethyl)sulfonyl)amide
InChI InChI=1S/C8H7N2O3S.Na/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7;/h1-4H,5H2,(H-,9,11,12);/q-1;+1
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Introduction

Zonisamide sodium is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug. Target: Calcium channel inhibitor; Sodium channel inhibitor Zonisamide sodium is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures for adults; infantile spasm, mixed seizure types of Lennox-Gastaut syndrome, myoclonic, and generalized tonic clonic seizure.

Background Information

Zonisamide sodium salt is an anti-epileptic. It is effective in various animal epilepsy models and humans with both partial and generalized epileptic seizures. Zonisamide sodium salt also scavenges nitric oxide (NO). ......by AbMole BioScience
Zonisamide is the first agent of this chemical class to be developed as an antiepileptic drug blocks repetitive firing of voltagesensitive sodium channels and reduces voltage-sensitive T-type calcium currents. ......by BOC Sciences
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000013071

Storage condition

Solubility

DMSO 42 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways Membrane Transporter/Ion Channel
Target Calcium Channel Sodium Channel
Research Area Neurological Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Zonisamide (sodium) - Launched
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Safety Data of Zonisamide (sodium)

´╗┐Hazard Symbols : Xn
´╗┐Risk Statements : 22
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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AbMole BioScience USA
Apexbio Technology LLC USA
Apichem Chemical Technology Co., Ltd. China
Ark Pharm, Inc. USA
BOC Sciences
Beijing Gaobo Pharm-Chemicals Tech. Co., Ltd CHINA
CHEMSCENE, LLC 200mg/USD103();500mg/USD163() USA
MedChemexpress Co., Ltd. 200mg/USD103();500mg/USD163() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 200mg/USD103();500mg/USD163() China
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Related Products

Other Forms of 68291-98-5

Name CAS No Formula MW
Zonisamide 68291-97-4 C8H8N2O3S 212.23

Recommended Compounds in Calcium Channel Sodium Channel

Name CAS No Formula MW
Lercanidipine (hydrochloride) 132866-11-6 C36H42ClN3O6 648.19
Amlodipine (maleate) 88150-47-4 C24H29ClN2O9 524.9481
Lercanidipine 100427-26-7 C36H41N3O6 611.73
Neomycin (sulfate) 1405-10-3 C23H48N6O17S 712.72
Tetracaine (hydrochloride) 136-47-0 C15H25ClN2O2 300.82
Nitrendipine 39562-70-4 C18H20N2O6 360.36
Manidipine 89226-50-6 C35H38N4O6 610.7
Chlorpromazine (hydrochloride) 69-09-0 C17H20Cl2N2S 355.33
Ibutilide (fumarate) 122647-32-9 C44H76N4O10S2 885.23
Flunarizine (dihydrochloride) 30484-77-6 C26H28Cl2F2N2 477.42
Lacidipine 103890-78-4 C26H33NO6 455.54
Cromolyn (sodium) 15826-37-6 C23H14Na2O11 512.33
Amlodipine 88150-42-9 C20H25ClN2O5 408.88
Felodipine 72509-76-3 C18H19Cl2NO4 384.25
Nifedipine 21829-25-4 C17H18N2O6 346.33
Acetylcholine (chloride) 60-31-1 C7H16ClNO2 181.6604
Ranolazine 95635-55-5 C24H33N3O4 427.54
Nimodipine 66085-59-4 C21H26N2O7 418.44
Isradipine 75695-93-1 C19H21N3O5 371.39
Zonisamide 68291-97-4 C8H8N2O3S 212.23

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Zonisamide (sodium)

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