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54-31-9 (Furosemide)

1

Identification

Furosemide Furosemide
Name Furosemide
Formula C12H11ClN2O5S
MW 330.74
CAS No. 54-31-9
EINECS 200-203-6
Smiles OC(C1=CC(S(N)(=O)=O)=C(Cl)C=C1NCC2=CC=CO2)=O
Synonyms 5-(Aminosulfonyl)-4-chloro-2-((2-furanylmethyl)amino)benzoic acid; 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid; 2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid; 4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoic acid
InChI InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)
2

Introduction

Furosemide (Lasix) is a loop diuretic inhibitor of Na+/2Cl-/K+ (NKCC) cotransporter of which used in the treatment of congestive heart failure and edema. Target: NKCC Furosemide (INN/BAN) or frusemide is a loop diuretic used in the treatment of congestive heart failure and edema.

Background Information

Furosemide is a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors.
......by AdooQ BioScience, LLC
Furosemide is a loop diuretic used in the treatment of congestive heart failure and edema. ......by BOC Sciences
Furosemide is a loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) symporter. It also acts as a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors. ......by MedKoo Biosciences, Inc.
Furosemide is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used in the treatment of congestive heart failure and edema. ......by Selleck Chemicals LLC
Furosemide is a loop diuretic inhibitor of Na+/2Cl-/K+ (NKCC) cotransporter. Furosemide acts as a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors. ......by Target Molecule Corp.
Loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) symporter. Also acts as a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000013014

Storage condition

Store at RT by Tocris Bioscience Inc.

Solubility

DMSO 66 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 66 mg/mL (199.55 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
Soluble to 100 mM in DMSO by Tocris Bioscience Inc.
5

Mechanism and Indication

Signaling Pathways Membrane Transporter/Ion Channel
Target NKCC
Research Area Metabolic Disease
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Furosemide - Launched
7

Safety Data of Furosemide

Hazard Symbols : T
Risk Statements : R61
Safety Statements : S22;S36/37/39;S53;S45
RTECS : CB2625000
WGKGermany : 3
8

Spectral Information

9

Suppliers List

10

Related Products

Other Forms of 54-31-9

Name CAS No Formula MW
Furosemide (sodium) 41733-55-5 C12H10ClN2NaO5S 352.73

Recommended Compounds in NKCC

Name CAS No Formula MW
Furosemide (sodium) 41733-55-5 C12H10ClN2NaO5S 352.73
Bumetanide 28395-03-1 C17H20N2O5S 364.42

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Furosemide

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