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148849-67-6 (Ivabradine (hydrochloride))

1

Identification

Ivabradine (hydrochloride) Ivabradine (hydrochloride)
Name Ivabradine (hydrochloride)
Formula C27H37ClN2O5
MW 505.05
CAS No. 148849-67-6
EINECS
Smiles CN(CCCN(CCC(C=C1OC)=C(C=C1OC)C2)C2=O)C[[email protected]@H]3C4=CC(OC)=C(OC)C=C4C3.Cl
Synonyms 3-[3-[[(8S)-3,4-Dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride; (S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one hydrochloride
InChI InChI=1S/C27H36N2O5.ClH/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30;/h12-14,16,21H,6-11,15,17H2,1-5H3;1H/t21-;/m1./s1
2

Introduction

Ivabradine hydrochloride, a new If inhibitor with IC 50 of 2.9 μM, which is a pure heart rate lowering agent.

Background Information

Ivabradine HCl, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent. ......by AbMole BioScience
Ivabradine Hydrochloride, also known as S-16257, is the hydrochloride salt preparation of Ivabradine, a bradycardic agent. ......by AdooQ BioScience, LLC
Ivabradine Hydrochloride is the hydrochloride salt preparation of Ivabradine, a bradycardic agent. Studies have shown that Ivabradine inhibits T cell migration and causes a decrease of chemokine-induced PI-3 kinase activity. Exposure of rabbit sinoatrial node cells to Ivabradine has been reported to cause a blockade of the hyperpolarization-activated I(f) current without resulting in a shift of the voltage range of the activation curve. ......by Affix Scientific
a highly selective open channel blocker ......by BOC Sciences
Ivabradine hydrochloride is a highly selective open channel blocker that targets the mixed Na⁺/K⁺ inward “funny current” (If) carried by hyperpolarization-activated cyclic nucleotide gated (HCN) channels. It has antianginal activity. It lowers heart rate and reduces myocardial oxygen demand. ......by BioVision, Inc.,
Ivabradine (hydrochloride) is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent. ......by MedChemexpress Co., Ltd.
Ivabradine is a novel medication used for the symptomatic management of stable angina pectoris. Ivabradine acts by reducing the heart rate via specific inhibition of the funny channel, a mechanism different from that of beta blockers and calcium channel blockers, two commonly prescribed antianginal drugs. Ivabradine is a cardiotonic agent. Ivabradine was approved in 2015. Ivabradine acts on the If (f is for "funny", so called because it had unusual properties compared with other current systems known at the time of its discovery) ion current, which is highly expressed in the sinoatrial node. If is a mixed Na+–K+ inward current activated by hyperpolarization and modulated by the autonomic nervous system. It is one of the most important ionic currents for regulating pacemaker activity in the sinoatrial (SA) node. Ivabradine selectively inhibits the pacemaker If current in a dose-dependent manner. Blocking this channel reduces cardiac pacemaker activity, slowing the heart rate and allowing more time for blood to flow to the myocardium. ......by MedKoo Biosciences, Inc.
Ivabradine HCl, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent. ......by Selleck Chemicals LLC
Ivabradine hydrochloride, a new If inhibitor with IC 50 of 2.9 μM, which is a pure heart rate lowering agent. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012955

Storage condition

Up to one week at 4°C or six months at -20°C. by Affix Scientific

Solubility

DMSO 100 mg/mL; Water 82 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 101 mg/mL (199.98 mM); Ethanol101 mg/mL (199.98 mM); Water82 mg/mL (162.36 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways GPCR/G Protein
Target Adrenergic Receptor
Research Area Cardiovascular Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Ivabradine (hydrochloride) - Launched
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Safety Data of Ivabradine (hydrochloride)

Hazard Symbols : N
Risk Statements : 50/53
Safety Statements : 60-61
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Spectral Information

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Suppliers List

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Related Products

Other Forms of 148849-67-6

Name CAS No Formula MW
Ivabradine (D3 Hydrochloride) 1217809-61-4 C27H34D3ClN2O5 508.06
Ivabradine D6 1217977-70-2 C27H30D6N2O5 474.62
Ivabradine metabolite N-Demethyl Ivabradine (hydrochloride) 1246638-08-3 C26H35ClN2O5 491.02
Ivabradine 155974-00-8 C27H36N2O5 468.59

Recommended Compounds in Adrenergic Receptor

Name CAS No Formula MW
Tolazoline 59-98-3 C10H12N2 160.22
Synephrine (hydrochloride) 5985-28-4 C9H14ClNO2 203.67
(R)-(-)-Phenylephrine 59-42-7 C9H13NO2 167.205
Nicergoline 27848-84-6 C24H26BrN3O3 484.39
Tamsulosin (hydrochloride) 106463-17-6 C20H29ClN2O5S 444.97
Tamsulosin 106133-20-4 C20H28N2O5S 408.51
UK 14,304 59803-98-4 C11H10BrN5 292.13
Guanfacine 29110-47-2 C9H9Cl2N3O 246.09
Propranolol (hydrochloride) 318-98-9 C16H22ClNO2 295.8
Guanabenz (Acetate) 23256-50-0 C10H12Cl2N4O2 291.13
Tetrahydrozoline (hydrochloride) 522-48-5 C13H17ClN2 236.74
Octopamine (hydrochloride) 770-05-8 C8H12ClNO2 189.64
Betaxolol (hydrochloride) 63659-19-8 C18H30ClNO3 343.89
Indacaterol (maleate) 753498-25-8 C28H32N2O7 508.56
Medetomidine (hydrochloride) 86347-15-1 C13H17ClN2 236.74
Norepinephrine (bitartrate monohydrate) 108341-18-0 C12H19NO10 337.28
Norepinephrine (hydrochloride) 329-56-6 C8H12ClNO3 205.64
Xylometazoline (hydrochloride) 1218-35-5 C16H25ClN2 280.84
(R)-(-)-Phenylephrine (hydrochloride) 61-76-7 C9H14ClNO2 203.67
Isoprenaline (hydrochloride) 51-30-9 C11H18ClNO3 247.72

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Ivabradine (hydrochloride)

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