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90038-01-0 (Detomidine (hydrochloride))

1

Identification

Detomidine (hydrochloride) Detomidine (hydrochloride)
Name Detomidine (hydrochloride)
Formula C12H15ClN2
MW 222.71
CAS No. 90038-01-0
EINECS
Smiles CC1=C(C)C(CC2=CN=CN2)=CC=C1.Cl
Synonyms 5-(2,3-dimethylbenzyl)-1H-imidazole hydrochloride
InChI InChI=1S/C12H14N2.ClH/c1-9-4-3-5-11(10(9)2)6-12-7-13-8-14-12;/h3-5,7-8H,6H2,1-2H3,(H,13,14);1H
2

Introduction

Detomidine hydrochloride produce dose-dependent sedative and analgesic effects, is a nonnarcotic, synthetic α2-adrenergic agonist Target: α2-adrenergic agonist Detomidine is an imidazole derivative and α2-adrenergic agonist, used as a large animal sedative, primarily used in horses.

Background Information

alpha2-Adrenoreceptor agonist with sedative properties ......by AOBIOUS INC
Detomidine hydrochloride is a nonnarcotic, synthetic alpha-2 adrenoreceptor agonist. Detomidine produce dose-dependent sedative and analgesic effects, mediatated by activation of alpha-2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters. ......by AbMole BioScience
Detomidine is a sedative with analgesic properties. α2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters. ......by AdooQ BioScience, LLC
Detomidine HCl is an alpha2-Adrenoreceptor agonist with sedative properties. ......by MedKoo Biosciences, Inc.
Detomidine HCl produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012953

Storage condition

Solubility

DMSO 45 mg/mL (202 mM); Water 45 mg/mL (202 mM) by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 45 mg/mL (202.05 mM); Water45 mg/mL (202.05 mM); Ethanol45 mg/mL (202.05 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways GPCR/G Protein
Target Adrenergic Receptor
Research Area Neurological Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Detomidine (hydrochloride) - Launched
Detomidine (hydrochloride) - No Development Reported
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Safety Data of Detomidine (hydrochloride)

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AOBIOUS INC USA
AbMole BioScience USA
AdooQ BioScience, LLC USA
Anhui Lianchuang Pharmaceutical Chemistry Co., Ltd. China
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
Arpadis (China) Co., Ltd CHINA
BOC Sciences
Biochempartner Co., Ltd China
Brook Chemical Limited China
CHEMSCENE, LLC 10mg/USD60();50mg/USD96() USA
Cayman Chemical Company USA
JACX Chemical Co., Ltd. China
MedChemexpress Co., Ltd. 10mg/USD60();50mg/USD96() USA
MedKoo Biosciences, Inc. USA
PharmaSci Shanghai Co., Ltd. China
Selleck Chemicals LLC 10mg/USD110(In stock);10mM/1mLIn DMSO/USD140(In stock);100mg/USD770(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD60();50mg/USD96() China
Target Molecule Corp. 10mg/USD73();100mg/USD301() USA
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Related Products

Other Forms of 90038-01-0

Name CAS No Formula MW
Detomidine 76631-46-4 C12H14N2 186.25

Recommended Compounds in Adrenergic Receptor

Name CAS No Formula MW
Tolazoline 59-98-3 C10H12N2 160.22
Synephrine (hydrochloride) 5985-28-4 C9H14ClNO2 203.67
(R)-(-)-Phenylephrine 59-42-7 C9H13NO2 167.205
Nicergoline 27848-84-6 C24H26BrN3O3 484.39
Tamsulosin (hydrochloride) 106463-17-6 C20H29ClN2O5S 444.97
Tamsulosin 106133-20-4 C20H28N2O5S 408.51
UK 14,304 59803-98-4 C11H10BrN5 292.13
Guanfacine 29110-47-2 C9H9Cl2N3O 246.09
Propranolol (hydrochloride) 318-98-9 C16H22ClNO2 295.8
Guanabenz (Acetate) 23256-50-0 C10H12Cl2N4O2 291.13
Tetrahydrozoline (hydrochloride) 522-48-5 C13H17ClN2 236.74
Octopamine (hydrochloride) 770-05-8 C8H12ClNO2 189.64
Betaxolol (hydrochloride) 63659-19-8 C18H30ClNO3 343.89
Indacaterol (maleate) 753498-25-8 C28H32N2O7 508.56
Medetomidine (hydrochloride) 86347-15-1 C13H17ClN2 236.74
Norepinephrine (bitartrate monohydrate) 108341-18-0 C12H19NO10 337.28
Norepinephrine (hydrochloride) 329-56-6 C8H12ClNO3 205.64
Xylometazoline (hydrochloride) 1218-35-5 C16H25ClN2 280.84
(R)-(-)-Phenylephrine (hydrochloride) 61-76-7 C9H14ClNO2 203.67
Isoprenaline (hydrochloride) 51-30-9 C11H18ClNO3 247.72

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Detomidine (hydrochloride)

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