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1177-87-3 (Dexamethasone (acetate))

1

Identification

Dexamethasone (acetate) Dexamethasone (acetate)
Name Dexamethasone (acetate)
Formula C24H31FO6
MW 434.5
CAS No. 1177-87-3
EINECS 214-646-8
Smiles C[[email protected]]1(C[[email protected]@H]2O)[[email protected]](C[[email protected]@H](C)[[email protected]]1(O)C(COC(C)=O)=O)([H])[[email protected]@](CC3)([H])[[email protected]@]2(F)[[email protected]](C=C4)(C)C3=CC4=O
Synonyms Dexamethasone acetate; 9a-Fluoro-16a-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate; 2-((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
InChI InChI=1S/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3/t13-,17+,18+,19+,21+,22+,23+,24+/m1/s1
2

Introduction

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs that has anti-inflammatory and immunosuppressant properties. IC50 Value: 58 nM (HECM-induced eosinophil survival) [1] Target: in vitro: DEX in concentrations from 1 to 100μM did not change LDH release but exposure to 10μM and 100μM DEX for 24, 48 and 72h caused a significant reduction in cell viability and proliferation as confirmed by MTT reduction and BrdU ELISA assays, respectively [2].

Background Information

The acetate-protect form of Dexamethasone which is a glucocorticoid and could be used as a anti-inflammatory agent. ......by BOC Sciences
Dexamethasone acetate is a glucocorticoid receptor agonist. ......by MedChemexpress Co., Ltd.
Dexamethasone acetate is an anti-inflammatory glucocorticoid. Injectable and topical formulations containing dexamethasone acetate have been used to treat inflammation associated with carpal tunnel syndrome, ocular keratitis, asthma exacerbations, and infertility in men. ......by MedKoo Biosciences, Inc.
Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. ......by Selleck Chemicals LLC
Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs that has anti-inflammatory and immunosuppressant properties. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

Animal Models Sprague-Dawley rats
Dosage 100 μg/kg
Formulation Saline
Administration Intraperitoneal injection
Source Selleck Chemicals LLC
4

Physical and Chemical Properties

Appearance: EBNumber:EB000012926

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 87 mg/mL (200.23 mM); Ethanol20 mg/mL (46.02 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways Autophagy GPCR/G Protein
Target Glucocorticoid Receptor Autophagy
Research Area Inflammation/Immunology
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Dexamethasone (acetate) - Launched
7

Safety Data of Dexamethasone (acetate)

Hazard Symbols : Xi
Risk Statements : R43
Safety Statements : S36/37
RTECS : TU4050000
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
Abcam 50mg/USD135() USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences 5g/USD399(In stock)
Biochempartner Co., Ltd China
CHEMSCENE, LLC 1g/USD108();5g/USD264() USA
Cayman Chemical Company USA
MedChemexpress Co., Ltd. 1g/USD108();5g/USD264() USA
MedKoo Biosciences, Inc. USA
Santa Cruz Biotechnology, Inc. 100mg/USD57() USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock);10mM(in 1mL DMSO)/USD163(in 1mL DMSO) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 1g/USD108();5g/USD264() China
Sigma-Aldrich, Inc. 100mg/USD43() USA
Spectrum Chemical Mfg. Corp. 1g/USD139() USA
Target Molecule Corp. 2mg/USD20();10mg/USD42();50mg/USD78();200mg/USD122() USA
Tianjin Jinjin Pharmaceutical Co., Ltd CHINA
Wonder Scientific Co., Ltd. China
10

Related Products

Other Forms of 1177-87-3

Name CAS No Formula MW
Dexamethasone 50-02-2 C22H29FO5 392.46

Recommended Compounds in Glucocorticoid Receptor Autophagy

Name CAS No Formula MW
(20S)-Protopanaxatriol 34080-08-5 C30H52O4 476.73
Prednisolone (disodium phosphate) 125-02-0 C21H27Na2O8P 484.39
Triamcinolone (acetonide) 76-25-5 C24H31FO6 434.5
Ciclesonide 126544-47-6 C32H44O7 540.69
Fluocinonide 356-12-7 C26H32F2O7 494.52
Fluocinolone (Acetonide) 67-73-2 C24H30F2O6 452.49
Triamcinolone 124-94-7 C21H27FO6 394.43
Methylprednisolone 83-43-2 C22H30O5 374.47
Desonide 638-94-8 C24H32O6 416.51
Meprednisone 1247-42-3 C22H28O5 372.45
Prednisone 53-03-2 C21H26O5 358.43
Fluticasone (propionate) 80474-14-2 C25H31F3O5S 500.57
Betamethasone (hydrochloride) 956901-32-9 C22H30ClFO5 428.92
Hydrocortisone 50-23-7 C21H30O5 362.46
Prednisolone 50-24-8 C21H28O5 360.44
Cortisone (acetate) 50-04-4 C23H30O6 402.48
Cortisone 53-06-5 C21H28O5 360.44
AL 082D06 256925-03-8 C23H24ClN3O2 409.91
Mometasone furoate 83919-23-7 C32H32Cl2O8 615.5
Mifepristone 84371-65-3 C29H35NO2 429.59

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

13

More Information

Dexamethasone (acetate)

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