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71125-38-7 (Meloxicam)

1

Identification

Meloxicam Meloxicam
Name Meloxicam
Formula C14H13N3O4S2
MW 351.4
CAS No. 71125-38-7
EINECS
Smiles O=C(C1=C(O)C2=CC=CC=C2S(N1C)(=O)=O)NC3=NC=C(C)S3
Synonyms Mobic;Metacam;UH-AC 62XX;Coxicam; 4-hydroxy-2-methyl-N-(5-methylthiazol-2-yl)-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide
InChI InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19)
2

Introduction

Meloxicam is a nonsteroidal anti-inflammatory agent with analgesic and fever reducer effects. Target: COX-2 Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve the symptoms of arthritis, primary dysmenorrhea, fever; and as an analgesic, especially where there is an inflammatory component.

Background Information

Meloxicam (Mobic), is a non-steroidal anti-inflammatory agent.Meloxicam inhibits cyclooxygenase (COX), the enzyme responsible for converting arachidonic acid into prostaglandin H2--the first step in the synthesis of prostaglandins, which are mediators of inflammation. In additional, Meloxicam has demonstrated the ability to non-competitively inhibit erythrocyte PGD (6-phosphogluconate dehydrogenase) activity in vitro ......by Affix Scientific
Meloxicam (Mobic) is a nonsteroidal anti-inflammatory agent with analgesic and fever reducer effects. ......by BOC Sciences
Meloxicam is a non-steroidal anti-inflammatory agent and has been reported to inhibit the inducible isoform of Cox-2. Studies suggest that Meloxicam is Cox-2 preferential, therefore it will probably not display a lower gastrointestinal toxicity than non-selective anti-inflammatory agents. This compound has been shown to also inhibit prostanoid synthesis in inflammatory cells. It shows potent anti-inflammatory, antipyretic, and analgesic effects with low gastrointestinal toxicity in animal models. ......by MedKoo Biosciences, Inc.
Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects. ......by Selleck Chemicals LLC
Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve the symptoms of arthritis (juvenile rheumatoid arthritis, osteoarthritis, and rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. However, this medicine does not cure arthritis and will only help you as long as you continue to take it. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:light yellow to green yellow Solid EBNumber:EB000012666

Storage condition

Up to one week at 4°C or six months at -20°C. by Affix Scientific

Solubility

DMSO 30 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 30 mg/mL (85.37 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways Immunology/Inflammation Autophagy
Target COX Autophagy
Research Area Inflammation/Immunology
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Meloxicam - Launched
7

Safety Data of Meloxicam

Hazard Symbols : Xn,T
Risk Statements : 22-36/37/38-25
Safety Statements : 26-45
RTECS : DL0702000
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
AdooQ BioScience, LLC USA
Affix Scientific 1g/USD550(In stock) USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 100mg/USD60();500mg/USD180() USA
Cayman Chemical Company USA
Guangzhou Winsun Pharmaceutical Co., Ltd. China
Linhai Xinghua Chemical Factory China
MedChemexpress Co., Ltd. 100mg/USD60();500mg/USD180() USA
MedKoo Biosciences, Inc. USA
Pharmavantage (China) Limited China
Rota Pharm & Chem Co., Ltd. China
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shanghai Ecust Biomedicine Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD60();500mg/USD180() China
Shanghai Micro-Mega Industry Co., Ltd. China
Target Molecule Corp. 2mg/USD20();10mg/USD40();50mg/USD89();200mg/USD122() USA
Xi'an Huayao Pharm-Chem Institute China
Zhejiang Excel Pharmaceutical Co., Ltd. China
10

Related Products

Other Forms of 71125-38-7

Name CAS No Formula MW
MELOXICAM (SODIUM) 71125-39-8 C14H13N3NaO4S2+ 374.39

Recommended Compounds in COX Autophagy

Name CAS No Formula MW
Isoorientin 4261-42-1 C21H20O11 448.3769
Maslinic acid 4373-41-5 C30H48O4 472.7
Aceclofenac 89796-99-6 C16H13Cl2NO4 354.18
Zaltoprofen 74711-43-6 C17H14O3S 298.36
Ketorolac 74103-06-3 C15H13NO3 255.27
Loxoprofen 68767-14-6 C15H18O3 246.3
Mefenamic acid 61-68-7 C15H15NO2 241.29
Nabumetone 42924-53-8 C15H16O2 228.29
Triflusal 322-79-2 C10H7F3O4 248.16
Diclofenac (diethylamine) 78213-16-8 C18H22Cl2N2O2 369.29
Bufexamac 2438-72-4 C12H17NO3 223.27
Acemetacin 53164-05-9 C21H18ClNO6 415.82
Phenacetin 62-44-2 C10H13NO2 179.22
Tenoxicam 59804-37-4 C13H11N3O4S2 337.37
Flunixin (meglumine) 42461-84-7 0.0
Lornoxicam 70374-39-9 C13H10ClN3O4S2 371.82
Nimesulide 51803-78-2 C13H12N2O5S 308.31
Tolfenamic Acid 13710-19-5 C14H12ClNO2 261.7
Fenoprofen (Calcium) 34597-40-5 C30H26CaO6 522.6
Deracoxib 169590-41-4 C17H14F3N3O3S 397.37

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

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More Information

Meloxicam

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