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64872-77-1 (Butoconazole (nitrate))

1

Identification

Butoconazole (nitrate) Butoconazole (nitrate)
Name Butoconazole (nitrate)
Formula C19H18Cl3N3O3S
MW 474.79
CAS No. 64872-77-1
EINECS
Smiles ClC1=C(C(Cl)=CC=C1)SC(CN2C=CN=C2)CCC3=CC=C(Cl)C=C3.O[N+]([O-])=O
Synonyms 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenyl)sulfanyl-butyl]imidazole nitrate; 1-(4-(4-chlorophenyl)-2-((2,6-dichlorophenyl)thio)butyl)-1H-imidazole nitrate
InChI InChI=1S/C19H17Cl3N2S.HNO3/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22;2-1(3)4/h1-5,7-8,10-11,13,16H,6,9,12H2;(H,2,3,4)
2

Introduction

Butoconazole nitrate is an anti-fungal agent. Target: Antifungal butoconazole 1-BSR is an effective and safe alternative to longer-term therapy with miconazole nitrate (seven days) for vulvovaginal candidiasis [1].

Background Information

Butoconazole nitrate is an anti-fungal agent for IL-2, TNFα, IFN and GM-CSF with IC50 of 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively. ......by BOC Sciences
Butoconazole nitrate is an anti-fungal agent for IL-2, TNFα, IFN and GM-CSF with IC50 of 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively. ......by Selleck Chemicals LLC
Butoconazole is an imidazole antifungal used in gynecology. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012579

Storage condition

Solubility

DMSO 95 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 95 mg/mL (200.08 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways Anti-infection
Target Fungal
Research Area Infection
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Butoconazole (nitrate) - Launched
7

Safety Data of Butoconazole (nitrate)

Hazard Symbols : Xn
Risk Statements : 22
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
BOC Sciences
Beijing Hony Biopharma Technology Co., Ltd. China
Biochempartner Co., Ltd China
CHEMSCENE, LLC 100mg/USD60();200mg/USD96() USA
Jinan Orgachem Technology and Development Co., Ltd. China
MedChemexpress Co., Ltd. 100mg/USD60();200mg/USD96() USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD60();200mg/USD96() China
Shanghai Longschem Co., Ltd. China
Shanghai Mayao Chemical Technology Co., Ltd CHINA
Target Molecule Corp. 2mg/USD20();10mg/USD78();50mg/USD215();200mg/USD328() USA
Wonder Synthesis (Beijing) Science and Development Co., Ltd. China
10

Related Products

Other Forms of 64872-77-1

Name CAS No Formula MW
Butoconazole 64872-76-0 C19H17Cl3N2S 411.78

Recommended Compounds in Fungal

Name CAS No Formula MW
Micafungin 235114-32-6 C56H71N9O23S 1270.27
Pneumocandin B0 135575-42-7 C50H80N8O17 1065.21
UM729 1448723-60-1 C20H25N5O2 367.44
Sertaconazole (nitrate) 99592-39-9 C20H16Cl3N3O4S 500.78
Miconazole (nitrate) 22832-87-7 C18H15Cl4N3O4 479.14
Naftifine (hydrochloride) 65473-14-5 C21H22ClN 323.86
Hygromycin B 31282-04-9 C20H37N3O13 527.52
Miconazole 22916-47-8 C18H14Cl4N2O 416.13
Econazole (nitrate) 24169-02-6 C18H16Cl3N3O4 444.7
Ciclopirox 29342-05-0 C12H17NO2 207.27
Methasulfocarb 66952-49-6 C9H11NO4S2 261.32
Flumorph 211867-47-9 C21H22FNO4 371.4
Itraconazole 84625-61-6 C35H38Cl2N8O4 705.63
Tolnaftate 2398-96-1 C19H17NOS 307.41
Fenticonazole (Nitrate) 73151-29-8 C24H21Cl2N3O4S 518.41
Liranaftate 88678-31-3 C18H20N2O2S 328.43
Tioconazole 65899-73-2 C16H13Cl3N2OS 387.71
Bifonazole 60628-96-8 C22H18N2 310.39
Amphotericin B 1397-89-3 C47H73NO17 924.08
Amorolfine (hydrochloride) 78613-38-4 C21H36ClNO 353.97

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

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More Information

Butoconazole (nitrate)

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