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65899-73-2 (Tioconazole)

1

Identification

Tioconazole Tioconazole
Name Tioconazole
Formula C16H13Cl3N2OS
MW 387.71
CAS No. 65899-73-2
EINECS 265-973-8
Smiles ClC1=C(C=CC(Cl)=C1)C(OCC2=C(Cl)SC=C2)CN3C=CN=C3
Synonyms 1-[2-[(2-Chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)-ethyl]imidazole; Vagistat; 1-(2-((2-chlorothiophen-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
InChI InChI=1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2
2

Introduction

Tioconazole is an antifungal medication. Target: Antifungal Tioconazole is an antifungal medication of the Imidazole class used to treat infections caused by a fungus or yeast.

Background Information

Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by a fungus or yeast, with an average IC50 of 1.7 μM. ......by BOC Sciences
Tioconazole is an antifungal medication with an average IC50 of 1.7 μM. ......by Selleck Chemicals LLC
Tioconazole is an antifungal medication of the Imidazole class used to treat infections caused by a fungus or yeast. Tioconazole topical (skin) preparations are also available for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus". Tioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012548

Storage condition

Solubility

DMSO 78 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 78 mg/mL (201.18 mM); Ethanol78 mg/mL (201.18 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways Anti-infection
Target Fungal
Research Area Infection
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Tioconazole - Launched
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Safety Data of Tioconazole

Hazard Symbols : Xn
Risk Statements : 22
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
BOC Sciences
CHEMSCENE, LLC 5g/USD78();10g/USD108() USA
Hangzhou Cowin Pharma Co., Ltd. China
MedChemexpress Co., Ltd. 5g/USD78();10g/USD108() USA
Nanjing Chemph Co., Ltd. China
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5g/USD78();10g/USD108() China
Target Molecule Corp. 10mg/USD45();50mg/USD88();100mg/USD133() USA
Xuzhou Bestenchem Technology Co., Ltd CHINA
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Related Products

Other Forms of 65899-73-2

Name CAS No Formula MW

Recommended Compounds in Fungal

Name CAS No Formula MW
Micafungin 235114-32-6 C56H71N9O23S 1270.27
Pneumocandin B0 135575-42-7 C50H80N8O17 1065.21
UM729 1448723-60-1 C20H25N5O2 367.44
Sertaconazole (nitrate) 99592-39-9 C20H16Cl3N3O4S 500.78
Miconazole (nitrate) 22832-87-7 C18H15Cl4N3O4 479.14
Naftifine (hydrochloride) 65473-14-5 C21H22ClN 323.86
Hygromycin B 31282-04-9 C20H37N3O13 527.52
Miconazole 22916-47-8 C18H14Cl4N2O 416.13
Econazole (nitrate) 24169-02-6 C18H16Cl3N3O4 444.7
Ciclopirox 29342-05-0 C12H17NO2 207.27
Methasulfocarb 66952-49-6 C9H11NO4S2 261.32
Flumorph 211867-47-9 C21H22FNO4 371.4
Itraconazole 84625-61-6 C35H38Cl2N8O4 705.63
Tolnaftate 2398-96-1 C19H17NOS 307.41
Fenticonazole (Nitrate) 73151-29-8 C24H21Cl2N3O4S 518.41
Liranaftate 88678-31-3 C18H20N2O2S 328.43
Bifonazole 60628-96-8 C22H18N2 310.39
Butoconazole (nitrate) 64872-77-1 C19H18Cl3N3O3S 474.79
Amphotericin B 1397-89-3 C47H73NO17 924.08
Amorolfine (hydrochloride) 78613-38-4 C21H36ClNO 353.97

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Tioconazole

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