• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

41100-52-1 (Memantine (hydrochloride))



Memantine (hydrochloride) Memantine (hydrochloride)
Name Memantine (hydrochloride)
Formula C12H22ClN
MW 215.76
CAS No. 41100-52-1
EINECS 255-219-6
Smiles NC1(C2)CC3(C)CC2(C)CC(C3)C1.[H]Cl
Synonyms 1,3-Dimethylaminoadamantane hydrochloride; 3,5-Dimethyl-1-aminoadamantane hydrochloride; 3,5-Dimethyltricyclo(,7))decan-1-amine hydrochloride; 3,5-dimethyladamantan-1-amine hydrochloride
InChI InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H


Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, is used for the treatment of Alzheimer's disease. Target: NMDA Receptor Memantine (Ebixa, Axura, Namenda, Akatinol) is a moderate-affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off kinetics that inhibits excessive calcium influx induced by chronic overstimulation of the NMDA receptor.

Background Information

Memantine hydrochloride used in the treatment of alzheimer's disease. ......by AOBIOUS INC
Memantine hydrochloride is an antagonist at the NMDA receptor, binding to the ion channel site. it was used in the treatment of Parkinsonism. ......by AdooQ BioScience, LLC
Memantine is the first in a novel class of Alzheimer's disease medications acting on the glutamatergic system by blocking NMDA receptors.It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectivel ......by BOC Sciences
Memantine Hydrochloride is the hydrochloride salt of memantine, a low-affinity, voltage-dependent, noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Memantine binds to and inhibits cation channels of glutamanergic NMDA receptors located in the central nervous system, preventing the prolonged influx of calcium ions and the associated neuronal excitotoxicity, and thereby potentially enhancing cognitive function. Memantine is also a 5-hydroxytryptamine type 3 (5HT3) receptor and nicotinic receptor antagonist. ......by MedKoo Biosciences, Inc.
Memantine is an uncompetitive NMDA receptor antagonist. When using HEK293 cells express recombinant rat NMDA receptors, memantine shows inhibition of L-glutamate-mediated response with a dose- and voltage-dependent manner. Memantine also has a rapid unblocking kinetics. Memantine is used clinically in spasticity, Parkinson's disease and Alzheimer's disease. Memantine is found to attenuate the deleterious action of Aβ in the in vitro numerous studies. It is probably due to the decreased tau phosphorylation caused by memantine ......by Target Molecule Corp.
An antagonist at the NMDA receptor, binding to the ion channel site. Used in the treatment of Parkinsonism. Deuterated analog also available. ......by Tocris Bioscience Inc.

Protocol(Only for Reference)

Cell Experiment

Animal Experiment


Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012481

Storage condition

Store at RT by Tocris Bioscience Inc.


DMSO 45 mg/mL; Water 30 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 43 mg/mL (199.29 mM); Ethanol43 mg/mL (199.29 mM); Water30 mg/mL (139.04 mM) by Selleck Chemicals LLC
Soluble to 100 mM in water by Tocris Bioscience Inc.

Mechanism and Indication


Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Memantine (hydrochloride) - Launched

Safety Data of Memantine (hydrochloride)

Safety Statements : S24/25
WGKGermany : 3

Spectral Information


Suppliers List


Related Products

Other Forms of 41100-52-1

Name CAS No Formula MW
Memantine 19982-08-2 C12H21N 179.3

Recommended Compounds in Autophagy Cytochrome P450 iGluR

Name CAS No Formula MW
Pirarubicin (Hydrochloride) 95343-20-7 C32H38ClNO12 664.1
Berberine (chloride) 633-65-8 C20H18ClNO4 371.8142
DMH-1 1206711-16-1 C24H20N4O 380.44
CB-839 1439399-58-2 C26H24F3N7O3S 571.57
H-89 (dihydrochloride) 130964-39-5 C20H22BrCl2N3O2S 519.2826
Shikonin 517-89-5 C16H16O5 288.3
H 89 127243-85-0 C20H20BrN3O2S 446.36
Eupatilin 22368-21-4 C18H16O7 344.32
Isoalantolactone 470-17-7 C15H20O2 232.32
Scutellarein 529-53-3 C15H10O6 286.24
Leonurine 24697-74-3 C14H21N3O5 311.33
Berbamine (dihydrochloride) 6078-17-7 C37H42Cl2N2O6 681.6452
Ruxolitinib (S enantiomer) 941685-37-6 C17H18N6 306.37
D-Glucosamine (Hydrochloride) 66-84-2 C6H14ClNO5 215.63
Schizandrin A 61281-38-7 C22H28O6 388.45
Schisandrol B 58546-54-6 C23H28O7 416.46
Schisandrol A 7432-28-2 C24H32O7 432.51
Icaritin 118525-40-9 C21H20O6 368.3799
Bicyclol 118159-48-1 C19H18O9 390.34
Azithromycin 83905-01-5 C38H72N2O12 748.9845

Recommended Compounds in Same Indication

Name CAS No Formula MW

Route of Synthesis




More Information

Memantine (hydrochloride)

Tags: buy 41100-52-1 IC50 | 41100-52-1 price | 41100-52-1 cost | 41100-52-1 solubility | 41100-52-1 purchase | 41100-52-1 manufacturer | 41100-52-1 research buy | 41100-52-1 order | 41100-52-1 MSDS | 41100-52-1 chemical structure | 41100-52-1 Storage condition | 41100-52-1 molecular weight | 41100-52-1 mw | 41100-52-1 datasheet | 41100-52-1 supplier | 41100-52-1 cell line | 41100-52-1 NMR | 41100-52-1 MS | 41100-52-1 IR | 41100-52-1 solubility | 41100-52-1 Safe information | 41100-52-1 Qc and Spectral Information | 41100-52-1 Clinical Information | 41100-52-1 Clinical Trial | 41100-52-1 Route of Synthesis | 41100-52-1 storage condition | 41100-52-1 diseases and conditions | 41100-52-1 flash point | 41100-52-1 boiling point | 41100-52-1 melting point | 41100-52-1 storage condition | 41100-52-1 brand