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67-73-2 (Fluocinolone (Acetonide))

1

Identification

Fluocinolone (Acetonide) Fluocinolone (Acetonide)
Name Fluocinolone (Acetonide)
Formula C24H30F2O6
MW 452.49
CAS No. 67-73-2
EINECS 200-668-5
Smiles C[[email protected]@]12[[email protected]@](OC(C)(C)O3)(C(CO)=O)[[email protected]]3C[[email protected]@]1([H])[[email protected]@](C[[email protected]@H]4F)([H])[[email protected]]([[email protected]](C=C5)(C)C4=CC5=O)(F)[[email protected]@H](O)C2
Synonyms 6a,9a-Fifluoro-16a,17a-isopropylidenedioxy-1,4-pregnadiene-3,20-dione; (2S,6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-2,6b-difluoro-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-6a,6b,7,8,8a,8b,11a,12,12a,12b-decahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one
InChI InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1
2

Introduction

Fluocinolone Acetonide is a glucocorticoid derivative used topically in the treatment of various skin disorders. Target: Glucocorticoid Receptor Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching.

Background Information

Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It was also found to strongly potentiate TGF-β-associated chondrogenesis of bone marrow mesenchymal stem/progenitor cells, by increas ......by BOC Sciences
Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. A typical dosage strength used in dermatology is 0.01–0.025%. Fluocinolone acetonide was also found to strongly potentiate TGF-β-associated chondrogenesis of bone marrow mesenchymal stem/progenitor cells, by increasing the levels of collagen type II by more than 100 fold compared to the widely used dexamethasone. ......by MedKoo Biosciences, Inc.
Fluocinolone Acetonide is a corticosteroid that binds to the cytosolic glucocorticoid receptor. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012365

Storage condition

Solubility

DMSO 90 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 90 mg/mL (198.89 mM); Ethanol12 mg/mL (26.51 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways GPCR/G Protein
Target Glucocorticoid Receptor
Research Area Inflammation/Immunology
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Fluocinolone (Acetonide) - Launched
7

Safety Data of Fluocinolone (Acetonide)

Hazard Symbols : Xn
Risk Statements : R20/21/22;R36/37/38;R40
Safety Statements : S22;S26;S36
RTECS : TU3830000
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
2A Pharmachem USA USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 1g/USD120();5g/USD420() USA
Cayman Chemical Company USA
Hunan Steroid Chemicals Co., Ltd. China
Jiangxi Yuneng Pharmchem Co., Ltd. China
LKT Laboratories Inc. USA
MedChemexpress Co., Ltd. 1g/USD120();5g/USD420() USA
MedKoo Biosciences, Inc. USA
Nectar Industrial Co., Ltd. China
Selleck Chemicals LLC 100mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock);200mg/USD170(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 1g/USD120();5g/USD420() China
Shanghai Univic International Trading Corporation China
Target Molecule Corp. 5mg/USD24();10mg/USD42();50mg/USD83();200mg/USD120() USA
10

Related Products

Other Forms of 67-73-2

Name CAS No Formula MW

Recommended Compounds in Glucocorticoid Receptor

Name CAS No Formula MW
(20S)-Protopanaxatriol 34080-08-5 C30H52O4 476.73
Prednisolone (disodium phosphate) 125-02-0 C21H27Na2O8P 484.39
Triamcinolone (acetonide) 76-25-5 C24H31FO6 434.5
Ciclesonide 126544-47-6 C32H44O7 540.69
Fluocinonide 356-12-7 C26H32F2O7 494.52
Triamcinolone 124-94-7 C21H27FO6 394.43
Methylprednisolone 83-43-2 C22H30O5 374.47
Desonide 638-94-8 C24H32O6 416.51
Meprednisone 1247-42-3 C22H28O5 372.45
Prednisone 53-03-2 C21H26O5 358.43
Dexamethasone (acetate) 1177-87-3 C24H31FO6 434.5
Fluticasone (propionate) 80474-14-2 C25H31F3O5S 500.57
Betamethasone (hydrochloride) 956901-32-9 C22H30ClFO5 428.92
Hydrocortisone 50-23-7 C21H30O5 362.46
Prednisolone 50-24-8 C21H28O5 360.44
Cortisone (acetate) 50-04-4 C23H30O6 402.48
Cortisone 53-06-5 C21H28O5 360.44
AL 082D06 256925-03-8 C23H24ClN3O2 409.91
Mometasone furoate 83919-23-7 C32H32Cl2O8 615.5
Mifepristone 84371-65-3 C29H35NO2 429.59

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Fluocinolone (Acetonide)

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