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15500-66-0 (Pancuronium (dibromide))

1

Identification

Pancuronium (dibromide) Pancuronium (dibromide)
Name Pancuronium (dibromide)
Formula C35H60Br2N2O4
MW 732.67
CAS No. 15500-66-0
EINECS 239-532-5
Smiles C[N+]1([[email protected]@H]2[[email protected]@H](OC(C)=O)C[[email protected]@](CC[[email protected]]3([H])[[email protected]]4([H])CC[[email protected]@]5(C)[[email protected]@]3([H])C[[email protected]]([N+]6(C)CCCCC6)[[email protected]@H]5OC(C)=O)([H])[[email protected]]4(C)C2)CCCCC1.[Br-].[Br-]
Synonyms Pavulon; 1,1'-((2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3,17-diacetoxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-2,16-diyl)bis(1-methylpiperidin-1-ium) bromide
InChI InChI=1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1
2

Introduction

Pancuronium Dibromide is a bis-quaternary steroid that is a competitive nicotinic antagonist. Target: nAChR Pancuronium dibromide is a competitive AChR antagonist (IC50 = 5.5 nM) and acts as a skeletal muscle relaxant.

Background Information

Pancuronium results in open channel block of embryonic-type nicotinic acetylcholine receptor channels after coapplication of blocker and acetylcholine。 ......by BOC Sciences
Pancuronium Bromide, also known as Pavulon and NA-97, is a bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent, Pancuronium bromide is more potent than curare but has less effect on the circulatory system and on histamine release. ......by MedKoo Biosciences, Inc.
Pancuronium dibromide is a competitive nicotinic acetylcholine receptor antagonist, used as a muscle relaxant. ......by Selleck Chemicals LLC
Pancuronium dibromide is a competitive AChR antagonist (IC50 = 5.5 nM) and acts as a skeletal muscle relaxant. Pancuronium dibromide interrupts neuromuscular transmission by competing with acetylcholine for receptor sites on the motor end-plate. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:Off-white to pink Solid EBNumber:EB000012351

Storage condition

Solubility

DMSO 100 mg/mL; Water 100 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 100 mg/mL (136.48 mM); Water100 mg/mL (136.48 mM); Ethanol100 mg/mL (136.48 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Membrane Transporter/Ion Channel Neuronal Signaling
Target nAChR
Research Area Neurological Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Pancuronium (dibromide) - Launched
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Safety Data of Pancuronium (dibromide)

Hazard Symbols : Xn
Risk Statements : 22
RTECS : TN4930000
WGKGermany : 3
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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
Alfa Chemistry USA
Apexbio Technology LLC USA
BOC Sciences
Beijing Team Academy of Pharmaceutical Sciences Co., Ltd. China
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD60();50mg/USD144() USA
Cayman Chemical Company USA
Jinan Good Meditech Inc (GM) China
King Tang Chemical Group Industry Co., Ltd. China
MedChemexpress Co., Ltd. 10mg/USD60();50mg/USD144() USA
MedKoo Biosciences, Inc. USA
Nanjing Ange Pharmaceutical Co., Ltd. China
Selleck Chemicals LLC 25mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock);50mg/USD170(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD60();50mg/USD144() China
Target Molecule Corp. 2mg/USD20();10mg/USD60();25mg/USD108();50mg/USD198() USA
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Related Products

Other Forms of 15500-66-0

Name CAS No Formula MW

Recommended Compounds in nAChR

Name CAS No Formula MW
L-Nicotine 54-11-5 C10H14N2 162.23
Decamethonium (Bromide) 541-22-0 C16H38Br2N2 418.29
Hexamethonium (Bromide) 55-97-0 C12H30Br2N2 362.19
Meclofenoxate (hydrochloride) 3685-84-5 C12H17Cl2NO3 294.17
Adiphenine (hydrochloride) 50-42-0 C20H26ClNO2 347.88
Atracurium (besylate) 64228-81-5 0.0
Vecuronium (bromide) 50700-72-6 C34H57BrN2O4 637.73
Catharanthine 2468-21-5 C21H24N2O2 336.43
Vinblastine 865-21-4 C46H58N4O9 810.97
Cisatracurium (besylate) 96946-42-8 C65H82N2O18S2 1243.48
EVP-6124 (hydrochloride) 550999-74-1 C16H18Cl2N2OS 357.3
EVP-6124 550999-75-2 C16H17ClN2OS 320.84
ABT 894 799279-80-4 C10H11Cl2N3 244.12
Monepantel 887148-69-8 C20H13F6N3O2S 473.39
GTS-21 148372-04-7 C19H20N2O2 308.37
ZSET1446 887603-94-3 C15H12N2O 236.2686
Aniracetam 72432-10-1 C12H13NO3 219.24
CP-810123 439608-12-5 C14H18N4O 258.32
Varenicline (Tartrate) 375815-87-5 C17H19N3O6 361.35
Varenicline (Hydrochloride) 230615-23-3 C13H14ClN3 247.72

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Pancuronium (dibromide)

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