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| Smiles | O=C(N(C)C)C(N1C2CCCC2)=CC(C1=N3)=CN=C3NC(N=C4)=CC=C4N5CCNCC5.OC(CCC(O)=O)=O.[F,Cl,Br,I].O |
|---|---|
| Synonyms | LEE 011 succinate hydrate;LEE-011 succinate hydrate; |
| InChI | InChI=1S/C23H30N8O.C4H6O4.H2O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30;5-3(6)1-2-4(7)8;/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28);1-2H2,(H,5,6)(H,7,8);1H2 |
LEE011 succinate hydrate is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.
| LEE011 succinate hydrate is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. ......by BOC Sciences |
| LEE011 succinate hydrate is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. ......by MedChemexpress Co., Ltd. |
| Signaling Pathways | Cell Cycle/DNA Damage |
|---|
| Target | CDK |
|---|
| Research Area | Cancer |
|---|
| Indications | Breast tumor | Melanoma |
|---|
| Product Name | Sponsor & Collaborators | Indications | Start Date | End Date | Phase |
|---|---|---|---|---|---|
| LEE011 (succinate hydrate) | Novartis AG | Breast tumor | 2013/10/31 | 2014/4/30 | Phase 2 Clinical |
| LEE011 (succinate hydrate) | Novartis AG | Melanoma | 2013/4/30 | 2015/4/30 | Phase 2 Clinical |
| LEE011 (succinate hydrate) | - | Launched |
| Company | Price and Availability | Country/Region |
|---|---|---|
| Ark Pharm, Inc. | USA | |
| BOC Sciences | ||
| Biochempartner Co., Ltd | China | |
| CHEMSCENE, LLC | 5mg/USD60();10mg/USD84() | USA |
| DC Chemicals | China | |
| Lancrix Chemicals. | China | |
| MedChemexpress Co., Ltd. | 5mg/USD60();10mg/USD84() | USA |
| Shanghai Haoyuan Chemexpress Co., Ltd. | 5mg/USD60();10mg/USD84() | China |
| Name | CAS No | Formula | MW |
|---|---|---|---|
| LEE011 (succinate) | 1374639-75-4 | C27H36N8O5 | 552.63 |
| LEE011 (hydrochloride) | 1211443-80-9 | C23H31ClN8O | 471.0 |
| LEE011 | 1211441-98-3 | C23H30N8O | 434.54 |
| Name | CAS No | Formula | MW |
|---|---|---|---|
| LY2857785 | 1619903-54-6 | C26H36N6O | 448.6 |
| THZ2 | 1604810-84-5 | C31H28ClN7O2 | 566.0527 |
| Palbociclib (isethionate) | 827022-33-3 | C26H35N7O6S | 573.66 |
| CDK9-IN-6 | 1391855-95-0 | C27H37ClN6O2 | 513.07468 |
| ML167 | 1285702-20-6 | C19H17N3O3 | 335.36 |
| AMG 925 | 1401033-86-0 | C26H29N7O2 | 471.55 |
| LDC000067 | 1073485-20-7 | C18H18N4O3S | 370.43 |
| LEE011 (succinate) | 1374639-75-4 | C27H36N8O5 | 552.63 |
| LEE011 (hydrochloride) | 1211443-80-9 | C23H31ClN8O | 471.0 |
| LEE011 | 1211441-98-3 | C23H30N8O | 434.54 |
| WHI-P180 (hydrochloride) | 153437-55-9 | C16H16ClN3O3 | 333.77 |
| Wogonin | 632-85-9 | C16H12O5 | 284.26 |
| 1-NM-PP1 | 221244-14-0 | C20H21N5 | 331.41 |
| WHI-P180 | 211555-08-7 | C16H15N3O3 | 297.31 |
| THZ1 | 1604810-83-4 | C31H28ClN7O2 | 566.05 |
| Senexin A | 1366002-50-7 | C17H14N4 | 274.32 |
| CDK4-IN-1 | 1256963-02-6 | C22H29ClN8 | 440.97 |
| Palbociclib (hydrochloride) | 827022-32-2 | C24H30ClN7O2 | 483.99 |
| Purvalanol B | 212844-54-7 | C20H25ClN6O3 | 432.9 |
| NU6102 | 444722-95-6 | C18H22N6O3S | 402.47 |
| Name | CAS No | Formula | MW |
|---|---|---|---|
| Trametinib | 871700-17-3 | C26H23FIN5O4 | 615.39 |
| Toremifene | 89778-26-7 | C26H28ClNO | 405.96 |
| Toremifene (Citrate) | 89778-27-8 | C32H36ClNO8 | 598.08 |
| MLN4924 | 905579-51-3 | C21H25N5O4S | 443.52 |
| SB-590885 | 405554-55-4 | C27H27N5O2 | 453.54 |
| Betulinic acid | 472-15-1 | C30H48O3 | 456.7 |
| Fenretinide | 65646-68-6 | C26H33NO2 | 391.55 |
| FK866 | 658084-64-1 | C24H29N3O2 | 391.51 |
| Retaspimycin | 857402-23-4 | C31H45N3O8 | 587.7 |
| Retaspimycin (Hydrochloride) | 857402-63-2 | C31H46ClN3O8 | 624.17 |
| Motesanib (Diphosphate) | 857876-30-3 | C22H29N5O9P2 | 569.44 |
| Veliparib | 912444-00-9 | C13H16N4O | 244.29 |
| Veliparib (dihydrochloride) | 912445-05-7 | C13H18Cl2N4O | 317.21 |
| Ixabepilone | 219989-84-1 | C27H42N2O5S | 506.7 |
| Reparixin | 266359-83-5 | C14H21NO3S | 283.39 |
| Reparixin (L-lysine salt) | 266359-93-7 | C20H35N3O5S | 429.57 |
| Carboplatin | 41575-94-4 | C6H12N2O4Pt | 371.25 |
| Temozolomide | 85622-93-1 | C6H6N6O2 | 194.15 |
| SU14813 (maleate) | 849643-15-8 | C27H31FN4O8 | 558.56 |
| 5-Fluorouracil | 51-21-8 | C4H3FN2O2 | 130.08 |
