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1374639-79-8 (LEE011 (succinate hydrate))

1

Identification

LEE011 (succinate hydrate) LEE011 (succinate hydrate)
Name LEE011 (succinate hydrate)
Formula C27H38N8O6X
MW 570.64
CAS No. 1374639-79-8
EINECS
Smiles O=C(N(C)C)C(N1C2CCCC2)=CC(C1=N3)=CN=C3NC(N=C4)=CC=C4N5CCNCC5.OC(CCC(O)=O)=O.[F,Cl,Br,I].O
Synonyms LEE 011 succinate hydrate;LEE-011 succinate hydrate;
InChI
2

Introduction

LEE011 succinate hydrate is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.

Background Information

LEE011 succinate hydrate is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. ......by BOC Sciences
LEE011 succinate hydrate is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. ......by MedChemexpress Co., Ltd.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000012247

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways Cell Cycle/DNA Damage
Target CDK
Research Area Cancer
Indications Breast tumor Melanoma
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
LEE011 (succinate hydrate) Novartis AG Breast tumor 2013/10/31 2014/4/30 Phase 2 Clinical
LEE011 (succinate hydrate) Novartis AG Melanoma 2013/4/30 2015/4/30 Phase 2 Clinical
LEE011 (succinate hydrate) - Launched
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Safety Data of LEE011 (succinate hydrate)

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD60();10mg/USD84() USA
DC Chemicals China
Lancrix Chemicals. China
MedChemexpress Co., Ltd. 5mg/USD60();10mg/USD84() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD60();10mg/USD84() China
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Related Products

Other Forms of 1374639-79-8

Name CAS No Formula MW
LEE011 (succinate) 1374639-75-4 C27H36N8O5 552.63
LEE011 (hydrochloride) 1211443-80-9 C23H31ClN8O 471.0
LEE011 1211441-98-3 C23H30N8O 434.54

Recommended Compounds in CDK

Name CAS No Formula MW
LY2857785 1619903-54-6 C26H36N6O 448.6
THZ2 1604810-84-5 C31H28ClN7O2 566.0527
Palbociclib (isethionate) 827022-33-3 C26H35N7O6S 573.66
CDK9-IN-6 1391855-95-0 C27H37ClN6O2 513.07468
ML167 1285702-20-6 C19H17N3O3 335.36
AMG 925 1401033-86-0 C26H29N7O2 471.55
LDC000067 1073485-20-7 C18H18N4O3S 370.43
LEE011 (succinate) 1374639-75-4 C27H36N8O5 552.63
LEE011 (hydrochloride) 1211443-80-9 C23H31ClN8O 471.0
LEE011 1211441-98-3 C23H30N8O 434.54
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 333.77
Wogonin 632-85-9 C16H12O5 284.26
1-NM-PP1 221244-14-0 C20H21N5 331.41
WHI-P180 211555-08-7 C16H15N3O3 297.31
THZ1 1604810-83-4 C31H28ClN7O2 566.05
Senexin A 1366002-50-7 C17H14N4 274.32
CDK4-IN-1 1256963-02-6 C22H29ClN8 440.97
Palbociclib (hydrochloride) 827022-32-2 C24H30ClN7O2 483.99
Purvalanol B 212844-54-7 C20H25ClN6O3 432.9
NU6102 444722-95-6 C18H22N6O3S 402.47

Recommended Compounds in Same Indication

Name CAS No Formula MW
Trametinib 871700-17-3 C26H23FIN5O4 615.39
Toremifene 89778-26-7 C26H28ClNO 405.96
Toremifene (Citrate) 89778-27-8 C32H36ClNO8 598.08
MLN4924 905579-51-3 C21H25N5O4S 443.52
SB-590885 405554-55-4 C27H27N5O2 453.54
Betulinic acid 472-15-1 C30H48O3 456.7
Fenretinide 65646-68-6 C26H33NO2 391.55
FK866 658084-64-1 C24H29N3O2 391.51
Retaspimycin 857402-23-4 C31H45N3O8 587.7
Retaspimycin (Hydrochloride) 857402-63-2 C31H46ClN3O8 624.17
Motesanib (Diphosphate) 857876-30-3 C22H29N5O9P2 569.44
Veliparib 912444-00-9 C13H16N4O 244.29
Veliparib (dihydrochloride) 912445-05-7 C13H18Cl2N4O 317.21
Ixabepilone 219989-84-1 C27H42N2O5S 506.7
Reparixin 266359-83-5 C14H21NO3S 283.39
Reparixin (L-lysine salt) 266359-93-7 C20H35N3O5S 429.57
Carboplatin 41575-94-4 C6H12N2O4Pt 371.25
Temozolomide 85622-93-1 C6H6N6O2 194.15
SU14813 (maleate) 849643-15-8 C27H31FN4O8 558.56
5-Fluorouracil 51-21-8 C4H3FN2O2 130.08
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Route of Synthesis

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References

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More Information

LEE011 (succinate hydrate)

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