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24169-02-6 (Econazole (nitrate))

1

Identification

Econazole (nitrate) Econazole (nitrate)
Name Econazole (nitrate)
Formula C18H16Cl3N3O4
MW 444.7
CAS No. 24169-02-6
EINECS 246-053-5
Smiles [O-][N+](O)=O.ClC1=C(C=CC(Cl)=C1)C(OCC2=CC=C(Cl)C=C2)CN3C=CN=C3
Synonyms Spectazole;Ecostatin;Pevaryl;Palavale; 1-(2-((4-chlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole nitrate
InChI InChI=1S/C18H15Cl3N2O.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
2

Introduction

Econazole nitrate (Spectazole) is an imidazole class antifungal medication. Target: Antifungal Econazole nitrate is an antifungal medication of the imidazole class.

Background Information

Econazole nitrate is an antifungal medication of the imidazole class. ......by AdooQ BioScience, LLC
Econazole nitrate (Spectazole) is an imidazole class antifungal medication.It is used as a cream under the brand names Spectazole (United States), Ecostatin (Canada), Pevaryl (Western Europe), and Pevisone (the latter consisting of the combination econazo ......by BOC Sciences
Econazole nitrate is a broad spectrum ketoconazole-like azole based antifungal agent which is also potent against Gram positive bacteria. It is used topically in dermatomycoses as well as orally and parenterally. In studies, econazole nitrate is used on processes such as platelet serotonin uptake, prostanoid biosynthesis, EDHF-mediated relaxation, and Ca2+ transport pathways in thymic lymphocytes1. ......by MedKoo Biosciences, Inc.
Econazole Nitrate is a Ca2+ channel blocker, used as an antifungal medicine that fights infections caused by fungus. ......by Selleck Chemicals LLC
A broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012172

Storage condition

Solubility

DMSO 90 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 89 mg/mL (200.13 mM); Ethanol5 mg/mL (11.24 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Anti-infection
Target Fungal
Research Area Infection
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Econazole (nitrate) - Launched
7

Safety Data of Econazole (nitrate)

Hazard Symbols : Xn,Xi
Risk Statements : 22-36/38-36/37/38
Safety Statements : 26-36-36/37
RTECS : NI4450000
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
AdooQ BioScience, LLC USA
Ark Pharm, Inc. USA
BLD Pharmatech
BOC Sciences
CHEMSCENE, LLC 1g/USD60();5g/USD96() USA
Cayman Chemical Company USA
Jintan Chengxi Xinda Chemical Co. Ltd. China
Jurong Renxin Chemical Co., Ltd. China
MedChemexpress Co., Ltd. 1g/USD60();5g/USD96() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shaanxi Dasheng Chemical Tech Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 1g/USD60();5g/USD96() China
Target Molecule Corp. 1mg/USD20();5mg/USD40();10mg/USD67();50mg/USD198() USA
Yung Zip Chemical Co., Ltd. Taiwan, China
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Related Products

Other Forms of 24169-02-6

Name CAS No Formula MW
Econazole 27220-47-9 C18H15Cl3N2O 381.68

Recommended Compounds in Fungal

Name CAS No Formula MW
Micafungin 235114-32-6 C56H71N9O23S 1270.27
Pneumocandin B0 135575-42-7 C50H80N8O17 1065.21
UM729 1448723-60-1 C20H25N5O2 367.44
Sertaconazole (nitrate) 99592-39-9 C20H16Cl3N3O4S 500.78
Miconazole (nitrate) 22832-87-7 C18H15Cl4N3O4 479.14
Naftifine (hydrochloride) 65473-14-5 C21H22ClN 323.86
Hygromycin B 31282-04-9 C20H37N3O13 527.52
Miconazole 22916-47-8 C18H14Cl4N2O 416.13
Ciclopirox 29342-05-0 C12H17NO2 207.27
Methasulfocarb 66952-49-6 C9H11NO4S2 261.32
Flumorph 211867-47-9 C21H22FNO4 371.4
Itraconazole 84625-61-6 C35H38Cl2N8O4 705.63
Tolnaftate 2398-96-1 C19H17NOS 307.41
Fenticonazole (Nitrate) 73151-29-8 C24H21Cl2N3O4S 518.41
Liranaftate 88678-31-3 C18H20N2O2S 328.43
Tioconazole 65899-73-2 C16H13Cl3N2OS 387.71
Bifonazole 60628-96-8 C22H18N2 310.39
Butoconazole (nitrate) 64872-77-1 C19H18Cl3N3O3S 474.79
Amphotericin B 1397-89-3 C47H73NO17 924.08
Amorolfine (hydrochloride) 78613-38-4 C21H36ClNO 353.97

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

13

More Information

Econazole (nitrate)

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