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62-44-2 (Phenacetin)

1

Identification

Phenacetin Phenacetin
Name Phenacetin
Formula C10H13NO2
MW 179.22
CAS No. 62-44-2
EINECS 200-533-0
Smiles CC(NC1=CC=C(OCC)C=C1)=O
Synonyms 4'-Ethoxyacetanilide; 4-Acetophenetidine; N-(4-ethoxyphenyl)acetamide
InChI InChI=1S/C10H13NO2/c1-3-13-10-6-4-9(5-7-10)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12)
2

Introduction

Phenacetin is a non-opioid analgesic without anti-inflammatory properties. Target: COX Phenacetin is a pain-relieving and fever-reducing drug, Phenacetin was withdrawn from the Canadian market in June 1973 due to concerns regarding nephropathy.

Background Information

Phenacetin is a non-opioid analgesic without anti-inflammatory properties. ......by AbMole BioScience
Phenacetin is a non-opioid analgesic without anti-inflammatory properties. ......by AdooQ BioScience, LLC
Phenacetin is an analgesic used in research as the preferred marker for detecting CYP1A2-based inhibition potential in vitro. ......by MedKoo Biosciences, Inc.
Phenacetin is a non-opioid analgesic without anti-inflammatory properties. Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. Phenacetin is an antipyretic, acting on the brain to decrease the temperature set point. Phenacetin is also used to treat rheumatoid arthritis (subacute type) and intercostal neuralgia. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012148

Storage condition

Solubility

DMSO 35 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 36 mg/mL (200.87 mM); Ethanol36 mg/mL (200.87 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways Immunology/Inflammation
Target COX
Research Area Inflammation/Immunology
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Phenacetin - Launched
Phenacetin - No Development Reported
7

Safety Data of Phenacetin

Hazard Symbols : T
Risk Statements : R22;R45
Safety Statements : S45;S53
RTECS : AM4375000
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
AbMole BioScience USA
AdooQ BioScience, LLC USA
Alfa Chemistry USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BLD Pharmatech
Biochempartner Co., Ltd China
CHEMSCENE, LLC 1g/USD60();5g/USD96() USA
Cayman Chemical Company USA
Changzhou Sunchem Pharmaceutical Chemical Material Co., Ltd. China
Chem Service, Inc. USA
Crescent Chemical Co. Inc. USA
Hubie Xinyuanshun Pharm&Chem Co., Ltd. China
MedChemexpress Co., Ltd. 1g/USD60();5g/USD96() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shanghai Everchem Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 1g/USD60();5g/USD96() China
Target Molecule Corp. 2mg/USD20();10mg/USD42();50mg/USD98();200mg/USD122() USA
10

Related Products

Other Forms of 62-44-2

Name CAS No Formula MW

Recommended Compounds in COX

Name CAS No Formula MW
Isoorientin 4261-42-1 C21H20O11 448.3769
Maslinic acid 4373-41-5 C30H48O4 472.7
Aceclofenac 89796-99-6 C16H13Cl2NO4 354.18
Zaltoprofen 74711-43-6 C17H14O3S 298.36
Ketorolac 74103-06-3 C15H13NO3 255.27
Loxoprofen 68767-14-6 C15H18O3 246.3
Mefenamic acid 61-68-7 C15H15NO2 241.29
Nabumetone 42924-53-8 C15H16O2 228.29
Triflusal 322-79-2 C10H7F3O4 248.16
Diclofenac (diethylamine) 78213-16-8 C18H22Cl2N2O2 369.29
Bufexamac 2438-72-4 C12H17NO3 223.27
Acemetacin 53164-05-9 C21H18ClNO6 415.82
Tenoxicam 59804-37-4 C13H11N3O4S2 337.37
Flunixin (meglumine) 42461-84-7 0.0
Lornoxicam 70374-39-9 C13H10ClN3O4S2 371.82
Nimesulide 51803-78-2 C13H12N2O5S 308.31
Tolfenamic Acid 13710-19-5 C14H12ClNO2 261.7
Fenoprofen (Calcium) 34597-40-5 C30H26CaO6 522.6
Deracoxib 169590-41-4 C17H14F3N3O3S 397.37
Meloxicam 71125-38-7 C14H13N3O4S2 351.4

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Phenacetin

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