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65473-14-5 (Naftifine (hydrochloride))

1

Identification

Naftifine (hydrochloride) Naftifine (hydrochloride)
Name Naftifine (hydrochloride)
Formula C21H22ClN
MW 323.86
CAS No. 65473-14-5
EINECS
Smiles CN(C/C=C/C1=CC=CC=C1)CC2=C3C=CC=CC3=CC=C2.[H]Cl
Synonyms (E)-N-Cinnamyl-N-methyl(1-naphthylmethyl)amine hydrochloride; (E)-N-methyl-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine hydrochloride
InChI InChI=1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;
2

Introduction

Naftifine Hydrochloride is a synthetic, broad spectrum, antifungal agent. Target: Antifungal Naftifine exhibits an interesting in vitro spectrum of activity against dermatophytes (38 strains; minimal inhibitory concentration (MIC) range 0.1 to 0.2 mg/mL), aspergilli (6 strains; MIC range, 0.8 to 12.5 mg/mL), Sporothrix schenckii (2 strains; MICs, 0.8 and 1.5 mg/mL), and yeasts of the genus Candida (77 strains; MIC range, 1.5 to greater than 100 mg/mL) [1].

Background Information

Naftifine is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections). ......by AdooQ BioScience, LLC
Naftifine is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis, probably involves selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme. ......by BOC Sciences
Naftifine is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections). Its precise mechanism of action is unknown, but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme. The half-life is approximately 2–3 days. The metabolites are excreted in the urine and feces. ......by MedKoo Biosciences, Inc.
Naftifine is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis, probably involves selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme. ......by Selleck Chemicals LLC
Naftifine is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis, probably involves selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012002

Storage condition

Solubility

DMSO <1 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro Ethanol 8 mg/mL (24.7 mM); DMSO<1 mg/mL (<1 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Anti-infection
Target Fungal
Research Area Infection
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Naftifine (hydrochloride) - Launched
7

Safety Data of Naftifine (hydrochloride)

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
AdooQ BioScience, LLC USA
Ark Pharm, Inc. USA
BLD Pharmatech
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 1g/USD216();5g/USD660() USA
Cayman Chemical Company USA
Changzhou Tianhua Pharmaceutical Co., Ltd. China
Datang (Hangzhou) Pharmachem Co., Ltd. China
MedChemexpress Co., Ltd. 1g/USD216();5g/USD660() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 50mg/USD110(In stock);500mg/USD670(In stock) USA
Shanghai Biosundrug Science & Technology Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 1g/USD216();5g/USD660() China
Target Molecule Corp. 5mg/USD62();10mg/USD117();25mg/USD216() USA
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Related Products

Other Forms of 65473-14-5

Name CAS No Formula MW
Naftifine (hydrochloride) 65473-14-5 C21H22ClN 323.8591

Recommended Compounds in Fungal

Name CAS No Formula MW
Micafungin 235114-32-6 C56H71N9O23S 1270.27
Pneumocandin B0 135575-42-7 C50H80N8O17 1065.21
UM729 1448723-60-1 C20H25N5O2 367.44
Sertaconazole (nitrate) 99592-39-9 C20H16Cl3N3O4S 500.78
Miconazole (nitrate) 22832-87-7 C18H15Cl4N3O4 479.14
Hygromycin B 31282-04-9 C20H37N3O13 527.52
Miconazole 22916-47-8 C18H14Cl4N2O 416.13
Econazole (nitrate) 24169-02-6 C18H16Cl3N3O4 444.7
Ciclopirox 29342-05-0 C12H17NO2 207.27
Methasulfocarb 66952-49-6 C9H11NO4S2 261.32
Flumorph 211867-47-9 C21H22FNO4 371.4
Itraconazole 84625-61-6 C35H38Cl2N8O4 705.63
Tolnaftate 2398-96-1 C19H17NOS 307.41
Fenticonazole (Nitrate) 73151-29-8 C24H21Cl2N3O4S 518.41
Liranaftate 88678-31-3 C18H20N2O2S 328.43
Tioconazole 65899-73-2 C16H13Cl3N2OS 387.71
Bifonazole 60628-96-8 C22H18N2 310.39
Butoconazole (nitrate) 64872-77-1 C19H18Cl3N3O3S 474.79
Amphotericin B 1397-89-3 C47H73NO17 924.08
Amorolfine (hydrochloride) 78613-38-4 C21H36ClNO 353.97

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Naftifine (hydrochloride)

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