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42924-53-8 (Nabumetone)

1

Identification

Nabumetone Nabumetone
Name Nabumetone
Formula C15H16O2
MW 228.29
CAS No. 42924-53-8
EINECS
Smiles COC1=CC2=CC=C(CCC(C)=O)C=C2C=C1
Synonyms 4-(6-Methoxy-2-naphthyl)-2-butanone; Relafen; Relifex; 4-(6-methoxynaphthalen-2-yl)butan-2-one
InChI InChI=1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3
2

Introduction

Nabumetone(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX. Target: Others Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid family.

Background Information

Nabumetone is a non-steroidal anti-inflammatory compound and its active metabolite inhibits the COX. ......by AbMole BioScience
Nabumetone is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX. ......by BOC Sciences
Nabumetone is a non-steroidal anti-inflammatory drug (NSAID), the only 1-naphthaleneacetic acid derivative. It is a nonacidic NSAID that is rapidly metabolized in the liver to a major active metabolite, 6-methoxy-2-naphthyl acetic acid. As found with previous NSAIDs, nabumetone's active metabolite inhibits the cyclooxygenase enzyme and preferentially blocks COX-2 activity (which is indirectly responsible for the production of inflammation and pain during arthritis). The active metabolite of nabumetone is felt to be the compound primarily responsible for therapeutic effect. Comparatively, the parent drug is a poor inhibitor of COX-2 byproducts, particularly prostaglandins. It may be less nephrotoxic than indomethacin. ......by MedKoo Biosciences, Inc.
Nabumetone is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX. ......by Selleck Chemicals LLC
Nabumetone is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

Animal Models Rats
Dosage 1-200 mg/kg
Formulation
Administration Oral and s.c
Source Selleck Chemicals LLC
4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000011931

Storage condition

Solubility

DMSO 45 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 46 mg/mL (201.49 mM); Ethanol25 mg/mL (109.5 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways Immunology/Inflammation
Target COX
Research Area Inflammation/Immunology
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Nabumetone - Launched
7

Safety Data of Nabumetone

Hazard Symbols : Xn
Risk Statements : 22-40
Safety Statements : 36/37
RTECS : EL9085000
WGKGermany : 2
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AbMole BioScience USA
Alfa Chemistry USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5g/USD96();10g/USD168() USA
Cayman Chemical Company USA
Jiangsu Zhongdan Group Co., Ltd. China
MedChemexpress Co., Ltd. 5g/USD96();10g/USD168() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5g/USD96();10g/USD168() China
Target Molecule Corp. 2mg/USD20();10mg/USD78();50mg/USD165() USA
Yangzhou Lianhuan Pharmaceutical Co., Ltd. China
10

Related Products

Other Forms of 42924-53-8

Name CAS No Formula MW

Recommended Compounds in COX

Name CAS No Formula MW
Isoorientin 4261-42-1 C21H20O11 448.3769
Maslinic acid 4373-41-5 C30H48O4 472.7
Aceclofenac 89796-99-6 C16H13Cl2NO4 354.18
Zaltoprofen 74711-43-6 C17H14O3S 298.36
Ketorolac 74103-06-3 C15H13NO3 255.27
Loxoprofen 68767-14-6 C15H18O3 246.3
Mefenamic acid 61-68-7 C15H15NO2 241.29
Triflusal 322-79-2 C10H7F3O4 248.16
Diclofenac (diethylamine) 78213-16-8 C18H22Cl2N2O2 369.29
Bufexamac 2438-72-4 C12H17NO3 223.27
Acemetacin 53164-05-9 C21H18ClNO6 415.82
Phenacetin 62-44-2 C10H13NO2 179.22
Tenoxicam 59804-37-4 C13H11N3O4S2 337.37
Flunixin (meglumine) 42461-84-7 0.0
Lornoxicam 70374-39-9 C13H10ClN3O4S2 371.82
Nimesulide 51803-78-2 C13H12N2O5S 308.31
Tolfenamic Acid 13710-19-5 C14H12ClNO2 261.7
Fenoprofen (Calcium) 34597-40-5 C30H26CaO6 522.6
Deracoxib 169590-41-4 C17H14F3N3O3S 397.37
Meloxicam 71125-38-7 C14H13N3O4S2 351.4

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Nabumetone

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