• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

74103-06-3 (Ketorolac)

1

Identification

Ketorolac Ketorolac
Name Ketorolac
Formula C15H13NO3
MW 255.27
CAS No. 74103-06-3
EINECS
Smiles O=C(C1C2=CC=C(C(C3=CC=CC=C3)=O)N2CC1)O
Synonyms Acular LS;RS37619;Sprix;Toradol; 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
InChI InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)
2

Introduction

Ketorolac(RS37619), a non-selective COX inhibitor, is a non-steroidal anti-inflammatory drug.

Background Information

Ketorolac, a non-selective COX inhibitor, is a non-steroidal anti-inflammatory drug. It shows inhibition of eicosanoid formation in HEL cells (COX-1) and LPS-stimulated Mono Mac 6 cells (COX-2), but does not significantly inhibit NO accumulation in supern ......by BOC Sciences
Ketorolac is a synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic, and antipyretic activities. Ketorolac non-selectively inhibits the enzymes COX-1 and COX-2. The inhibition of COX-2, up-regulated at sites of inflammation, prevents conversion of arachidonic acid to pro-inflammatory prostaglandins. ......by BioVision, Inc.,
Ketorolac or ketorolac tromethamine is a non-steroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives, used as an analgesic. It acts by inhibiting the bodily synthesis of prostaglandins. Ketorolac in its oral (tablet or capsule) and intramuscular (injected) preparations is a racemic mixture of both (S)-(−)-ketorolac, the active isomer, and (R)-(+)-ketorolac. An ophthalmic solution of ketorolac is also used to treat eye pain and to relieve the itchiness and burning of seasonal allergies. ......by MedKoo Biosciences, Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB000011899

Storage condition

Solubility

DMSO 75 mg/mL; Water 75 mg/mL by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Immunology/Inflammation
Target COX
Research Area Inflammation/Immunology
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Ketorolac - Launched
7

Safety Data of Ketorolac

8

Spectral Information

9

Suppliers List

10

Related Products

Other Forms of 74103-06-3

Name CAS No Formula MW
Ketorolac (tromethamine salt) 74103-07-4 C19H24N2O6 376.4

Recommended Compounds in COX

Name CAS No Formula MW
Isoorientin 4261-42-1 C21H20O11 448.3769
Maslinic acid 4373-41-5 C30H48O4 472.7
Aceclofenac 89796-99-6 C16H13Cl2NO4 354.18
Zaltoprofen 74711-43-6 C17H14O3S 298.36
Loxoprofen 68767-14-6 C15H18O3 246.3
Mefenamic acid 61-68-7 C15H15NO2 241.29
Nabumetone 42924-53-8 C15H16O2 228.29
Triflusal 322-79-2 C10H7F3O4 248.16
Diclofenac (diethylamine) 78213-16-8 C18H22Cl2N2O2 369.29
Bufexamac 2438-72-4 C12H17NO3 223.27
Acemetacin 53164-05-9 C21H18ClNO6 415.82
Phenacetin 62-44-2 C10H13NO2 179.22
Tenoxicam 59804-37-4 C13H11N3O4S2 337.37
Flunixin (meglumine) 42461-84-7 0.0
Lornoxicam 70374-39-9 C13H10ClN3O4S2 371.82
Nimesulide 51803-78-2 C13H12N2O5S 308.31
Tolfenamic Acid 13710-19-5 C14H12ClNO2 261.7
Fenoprofen (Calcium) 34597-40-5 C30H26CaO6 522.6
Deracoxib 169590-41-4 C17H14F3N3O3S 397.37
Meloxicam 71125-38-7 C14H13N3O4S2 351.4

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Ketorolac

Tags: buy 74103-06-3 IC50 | 74103-06-3 price | 74103-06-3 cost | 74103-06-3 solubility | 74103-06-3 purchase | 74103-06-3 manufacturer | 74103-06-3 research buy | 74103-06-3 order | 74103-06-3 MSDS | 74103-06-3 chemical structure | 74103-06-3 Storage condition | 74103-06-3 molecular weight | 74103-06-3 mw | 74103-06-3 datasheet | 74103-06-3 supplier | 74103-06-3 cell line | 74103-06-3 NMR | 74103-06-3 MS | 74103-06-3 IR | 74103-06-3 solubility | 74103-06-3 Safe information | 74103-06-3 Qc and Spectral Information | 74103-06-3 Clinical Information | 74103-06-3 Clinical Trial | 74103-06-3 Route of Synthesis | 74103-06-3 storage condition | 74103-06-3 diseases and conditions | 74103-06-3 flash point | 74103-06-3 boiling point | 74103-06-3 melting point | 74103-06-3 storage condition | 74103-06-3 brand