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125-02-0 (Prednisolone (disodium phosphate))

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Identification

Prednisolone (disodium phosphate) Prednisolone (disodium phosphate)
Name Prednisolone (disodium phosphate)
Formula C21H27Na2O8P
MW 484.39
CAS No. 125-02-0
EINECS 204-722-9
Smiles C[[email protected]@]1([[email protected]](C(COP([O-])([O-])=O)=O)(O)CC2)[[email protected]]2([H])[[email protected]@](CCC3=CC4=O)([H])[[email protected]]([[email protected]@]3(C)C=C4)([H])[[email protected]@H](O)C1.[Na+].[Na+]
Synonyms (11b)-11,17-Dihydroxy-21-(phosphonooxy)-pregna-1,4-diene-3,20-dione disodium salt; Disodium prednisolone 21-phosphate; sodium 2-((8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl phosphate
InChI InChI=1S/C21H29O8P.2Na/c1-19-7-5-13(22)9-12(19)3-4-14-15-6-8-21(25,17(24)11-29-30(26,27)28)20(15,2)10-16(23)18(14)19;;/h5,7,9,14-16,18,23,25H,3-4,6,8,10-11H2,1-2H3,(H2,26,27,28);;/q;2*+1/p-2/t14-,15-,16-,18+,19-,20-,21-;;/m0../s1
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Introduction

Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Target: Glucocorticoid Receptor Prednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity.

Background Information

The disodium phosphate salt form of Prednisolone which has anti-inflammatory and immunsuppressive effect for behaving as a glucocorticoid. ......by BOC Sciences
Prednisolone sodium phosphate is a water soluble form of prednisolone, a glucocorticoid. It is used to treat a variety of inflammatory and autoimmune conditions and some cancers. It is the active metabolite of the drug prednisone and is used especially in patients with liver failure, as these individuals are unable to metabolize prednisone into active prednisolone. ......by MedKoo Biosciences, Inc.
Prednisolone Acetate is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000011806

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways GPCR/G Protein
Target Glucocorticoid Receptor
Research Area Inflammation/Immunology
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Prednisolone (disodium phosphate) - Launched
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Safety Data of Prednisolone (disodium phosphate)

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 100mg/USD72();500mg/USD96() USA
Cayman Chemical Company USA
Hunan Steroid Chemicals Co., Ltd. China
LKT Laboratories Inc. USA
MedChemexpress Co., Ltd. 100mg/USD72();500mg/USD96() USA
MedKoo Biosciences, Inc. USA
Shandong Taihua Bio. & Tech. Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD72();500mg/USD96() China
Taizhou Baida Pharmaceutical Co., Ltd. China
Target Molecule Corp. 10mg/USD20();50mg/USD78();100mg/USD145() USA
Techwin Bio.& Pharm.Technology Limited China
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Related Products

Other Forms of 125-02-0

Name CAS No Formula MW
Prednisolone 50-24-8 C21H28O5 360.44

Recommended Compounds in Glucocorticoid Receptor

Name CAS No Formula MW
(20S)-Protopanaxatriol 34080-08-5 C30H52O4 476.73
Triamcinolone (acetonide) 76-25-5 C24H31FO6 434.5
Ciclesonide 126544-47-6 C32H44O7 540.69
Fluocinonide 356-12-7 C26H32F2O7 494.52
Fluocinolone (Acetonide) 67-73-2 C24H30F2O6 452.49
Triamcinolone 124-94-7 C21H27FO6 394.43
Methylprednisolone 83-43-2 C22H30O5 374.47
Desonide 638-94-8 C24H32O6 416.51
Meprednisone 1247-42-3 C22H28O5 372.45
Prednisone 53-03-2 C21H26O5 358.43
Dexamethasone (acetate) 1177-87-3 C24H31FO6 434.5
Fluticasone (propionate) 80474-14-2 C25H31F3O5S 500.57
Betamethasone (hydrochloride) 956901-32-9 C22H30ClFO5 428.92
Hydrocortisone 50-23-7 C21H30O5 362.46
Prednisolone 50-24-8 C21H28O5 360.44
Cortisone (acetate) 50-04-4 C23H30O6 402.48
Cortisone 53-06-5 C21H28O5 360.44
AL 082D06 256925-03-8 C23H24ClN3O2 409.91
Mometasone furoate 83919-23-7 C32H32Cl2O8 615.5
Mifepristone 84371-65-3 C29H35NO2 429.59

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Prednisolone (disodium phosphate)

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