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22832-87-7 (Miconazole (nitrate))

1

Identification

Miconazole (nitrate) Miconazole (nitrate)
Name Miconazole (nitrate)
Formula C18H15Cl4N3O4
MW 479.14
CAS No. 22832-87-7
EINECS 245-256-6
Smiles [O-][N+](O)=O.ClC1=C(C=CC(Cl)=C1)C(OCC(C=CC(Cl)=C2)=C2Cl)CN3C=CN=C3
Synonyms Monistat nitrate;Daktarin IV nitrate;R18134 nitrate;Zimybase nitrate; 1-(2-((2,4-dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole nitrate
InChI InChI=1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)
2

Introduction

Miconazole Nitrate is an imidazole antifungal agent. Target: Antifungal Miconazole is an imidazole antifungal agent, developed by Janssen Pharmaceutica, commonly applied topically to the skin or to mucous membranes to cure fungal infections.

Background Information

An imidazole antimycotic compound; targets fungi that cause tinea (ringworm) and athleetes foot ......by BOC Sciences
Miconazole Nitrate is an imidazole antifungal agent by inhibiting ergosterol biosynthesis and inducing ROS, used to treat vaginal yeast infections. ......by Selleck Chemicals LLC
An imidazole antifungal agent that is used topically and by intravenous infusion. ......by Target Molecule Corp.
Antifungal agent. Inhibits lanosterol demethylase and induces formation of reactive oxygen species. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000011804

Storage condition

Store at RT by Tocris Bioscience Inc.

Solubility

DMSO 80 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 96 mg/mL (200.35 mM); Ethanol1 mg/mL (2.08 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
Soluble to 100 mM in DMSO and to 10 mM in ethanol by Tocris Bioscience Inc.
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Mechanism and Indication

Signaling Pathways Anti-infection
Target Fungal
Research Area Infection
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Miconazole (nitrate) - Launched
7

Safety Data of Miconazole (nitrate)

Hazard Symbols : Xn
Risk Statements : 22-43-40
Safety Statements : 36/37
RTECS : NI4771000
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Aakash Chemicals and Dye-Stuffs, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 1g/USD60();5g/USD96() USA
MedChemexpress Co., Ltd. 1g/USD60();5g/USD96() USA
Pure Chemistry Scientific Inc. 1g/USD499(In stock) USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 1g/USD60();5g/USD96() China
Target Molecule Corp. 5mg/USD25();10mg/USD45();50mg/USD154() USA
Tocris Bioscience Inc. USA
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Related Products

Other Forms of 22832-87-7

Name CAS No Formula MW
Miconazole 22916-47-8 C18H14Cl4N2O 416.13

Recommended Compounds in Fungal

Name CAS No Formula MW
Micafungin 235114-32-6 C56H71N9O23S 1270.27
Pneumocandin B0 135575-42-7 C50H80N8O17 1065.21
UM729 1448723-60-1 C20H25N5O2 367.44
Sertaconazole (nitrate) 99592-39-9 C20H16Cl3N3O4S 500.78
Naftifine (hydrochloride) 65473-14-5 C21H22ClN 323.86
Hygromycin B 31282-04-9 C20H37N3O13 527.52
Miconazole 22916-47-8 C18H14Cl4N2O 416.13
Econazole (nitrate) 24169-02-6 C18H16Cl3N3O4 444.7
Ciclopirox 29342-05-0 C12H17NO2 207.27
Methasulfocarb 66952-49-6 C9H11NO4S2 261.32
Flumorph 211867-47-9 C21H22FNO4 371.4
Itraconazole 84625-61-6 C35H38Cl2N8O4 705.63
Tolnaftate 2398-96-1 C19H17NOS 307.41
Fenticonazole (Nitrate) 73151-29-8 C24H21Cl2N3O4S 518.41
Liranaftate 88678-31-3 C18H20N2O2S 328.43
Tioconazole 65899-73-2 C16H13Cl3N2OS 387.71
Bifonazole 60628-96-8 C22H18N2 310.39
Butoconazole (nitrate) 64872-77-1 C19H18Cl3N3O3S 474.79
Amphotericin B 1397-89-3 C47H73NO17 924.08
Amorolfine (hydrochloride) 78613-38-4 C21H36ClNO 353.97

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Miconazole (nitrate)

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