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80-08-0 (Dapsone)

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Identification

Dapsone Dapsone
Name Dapsone
Formula C12H12N2O2S
MW 248.3
CAS No. 80-08-0
EINECS 201-248-4
Smiles O=S(C1=CC=C(N)C=C1)(C2=CC=C(N)C=C2)=O
Synonyms 4,4'-Diaminodiphenyl sulfone; Dapsonum; Bis(4-aminophenyl)sulfone; 4,4'-sulfonyldianiline
InChI InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2
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Introduction

Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Target: Antibacterial Dapsone is an antibacterial most commonly used in combination with rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae infections (leprosy).

Background Information

Dapsone is a synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties, commonly used for the treatment of leprosy. ......by AdooQ BioScience, LLC
Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae, which has anti-inflammatory and immunomodulatory effects. It is an antibacterial most commonly used in combination with rifampic ......by BOC Sciences
Dapsone is a drug used to treat Pneumocystis carinii pneumonia (PCP), which is a major infection affecting HIV patients. It is active against mycobacterium leprae and has a mechanism similar to that of sulfonamides. Dapsone has also been used to treat malaria. ......by MedKoo Biosciences, Inc.
Dapsone is a synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties, commonly used for the treatment of leprosy. It is a second-line medication for the treatment and prevention of Pneumocystis pneumonia and for the prevention of toxoplasmosis in those who have poor immune function. Additionally, it has been used for acne as well as other skin conditions. Dapsone is available both topically and by mouth. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. ......by MedKoo Biosciences, Inc.
Dapsone, also known as diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. ......by Selleck Chemicals LLC
A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000011704

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways Anti-infection
Target Bacterial
Research Area Infection
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Dapsone - Launched
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Safety Data of Dapsone

´╗┐Hazard Symbols : Xn
´╗┐Risk Statements : R22
Safety Statements : S22
HS Code : 29309070
RTECS : BY8925000
WGKGermany : 1
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Spectral Information

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Suppliers List

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Related Products

Other Forms of 80-08-0

Name CAS No Formula MW

Recommended Compounds in Bacterial

Name CAS No Formula MW
Fidaxomicin 873857-62-6 C52H74Cl2O18 1058.04
AVX 13616 900814-48-4 C50H73Cl2N7O7 955.06
Bedaquiline (fumarate) 845533-86-0 C36H35BrN2O6 671.58
Mafenide (Acetate) 13009-99-9 C9H14N2O4S 246.28
Cefozopran 113359-04-9 C19H17N9O5S2 515.53
Azithromycin 83905-01-5 C38H72N2O12 748.9845
Pazufloxacin 127045-41-4 C16H15FN2O4 318.3
Pazufloxacin (mesylate) 163680-77-1 C17H19FN2O7S 414.4054
Capreomycin (sulfate) 1405-37-4 C24H44N14O12S 752.76
Bleomycin (sulfate) 9041-93-4 C110H168N34O46S7 2927.17
G-418 (disulfate) 108321-42-2 C20H44N4O18S2 692.71
Demeclocycline (hydrochloride) 64-73-3 C21H22Cl2N2O8 501.31
Apramycin 37321-09-8 C21H41N5O11 539.58
Ceftriaxone 73384-59-5 C18H18N8O7S3 554.58
Ceftibuten 97519-39-6 C15H14N4O6S2 410.42
Vancomycin 1404-90-6 C66H76Cl3N9O24 1485.72
Lomefloxacin 98079-51-7 C17H19F2N3O3 351.35
Dirithromycin 62013-04-1 C42H78N2O14 835.07
Cefepime (Dihydrochloride Monohydrate) 123171-59-5 C19H28Cl2N6O6S2 571.5
Mafenide 138-39-6 C7H10N2O2S 186.23

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Dapsone

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