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144494-65-5 (Tirofiban)

1

Identification

Tirofiban Tirofiban
Name Tirofiban
Formula C22H36N2O5S
MW 440.6
CAS No. 144494-65-5
EINECS
Smiles OC([[email protected]@H](NS(CCCC)(=O)=O)CC1=CC=C(OCCCCC2CCNCC2)C=C1)=O
Synonyms (2S)-2-(Butylsulfonylamino)-3-[4-[4-(4-piperidyl)butoxy]phenyl]propanoic acid; (S)-2-(butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic acid
InChI InChI=1S/C22H36N2O5S/c1-2-3-16-30(27,28)24-21(22(25)26)17-19-7-9-20(10-8-19)29-15-5-4-6-18-11-13-23-14-12-18/h7-10,18,21,23-24H,2-6,11-17H2,1H3,(H,25,26)/t21-/m0/s1
2

Introduction

Tirofiban(L700462;MK383) is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist Target: integrin IIb/IIIa Tirofiban hydrochloride monohydrate blocks platelet aggregation and thrombus formation.

Background Information

Tirofiban (MK-383, Aggrastat) is a nonpeptide derivative of tyrosine that selectively inhibits the GP-IIb/IIIa receptor, with minimal effects on the ɑvβ3 vitronectin receptor. ......by BOC Sciences
Tirofiban is an antiplatelet drug. It belongs to a class of antiplatelet named glycoprotein IIb/IIIa inhibitors. Tirofiban is the first drug candidate whose origins can be traced to a pharmacophore-based virtual screening lead. Tirofiban is indicated to reduce the rate of thrombotic cardiovascular events (combined endpoint of death, myocardial infarction, or refractory ischemia/repeat cardiac procedure) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). ......by MedKoo Biosciences, Inc.
A potent, selective inhibitor of the platelet fibrinogen receptor GPIIb/IIIa with IC50 of 9 nM, inhibition of platelet aggregation; displays > 24,000-fold over human umbilical vein endothelial cell fibrinogen receptors; inhibits ex vivo platelet aggregation induced by ADP in anesthetized dogs.ThrombosisApproved ......by ProbeChem
Tirofiban (MK-383) is a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM. ......by Selleck Chemicals LLC
Tirofiban (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

Animal Models Adult mongrel dogs
Dosage ~500 mg/kg
Formulation In saline
Administration I.P.
Source Selleck Chemicals LLC
4

Physical and Chemical Properties

Appearance: EBNumber:EB000011599

Storage condition

Solubility

DMSO <1 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 0.005 mg/mL (0.01 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways Cytoskeleton
Target Integrin
Research Area Cardiovascular Disease
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Tirofiban - Launched
7

Safety Data of Tirofiban

Hazard Symbols : Xi
Risk Statements : 36/37/38
Safety Statements : 26
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Adipogen Corporation USA
Alfa Chemistry USA
Apichem Chemical Technology Co., Ltd. China
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
Broad Pharmaceutical Co., Ltd. China
CHEMSCENE, LLC 5mg/USD161();10mg/USD264() USA
MedChemexpress Co., Ltd. 5mg/USD161();10mg/USD264() USA
MedKoo Biosciences, Inc. USA
ProbeChem
Pure Chemistry Scientific Inc. 5mg/USD26(In stock) USA
Selleck Chemicals LLC 5mg/USD147(In stock);25mg/USD470(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD161();10mg/USD264() China
Sigma-Aldrich, Inc. 5mg/USD158() USA
Target Molecule Corp. 2mg/USD66();5mg/USD120();10mg/USD205();25mg/USD361();50mg/USD634() USA
10

Related Products

Other Forms of 144494-65-5

Name CAS No Formula MW
Tirofiban (hydrochloride monohydrate) 150915-40-5 C22H39ClN2O6S 495.0728
Tirofiban (hydrochloride monohydrate) 150915-40-5 C22H39ClN2O6S 495.07

Recommended Compounds in Integrin

Name CAS No Formula MW
Arg-Gly-Asp-Ser 91037-65-9 C15H27N7O8 433.42
Cucurbitacin B 6199-67-3 C32H46O8 558.7
TR-14035 232271-19-1 C24H21Cl2NO5 474.33
ATN-161 262438-43-7 C23H35N9O8S 597.64
Tirofiban (hydrochloride monohydrate) 150915-40-5 C22H39ClN2O6S 495.07
α4 integrin receptor antagonist 2 863228-66-4 C23H31N3O8 477.51
α4 integrin receptor antagonist 1 863227-78-5 C21H27N3O7 433.46
Cilengitide 188968-51-6 C27H40N8O7 588.66
Firategrast 402567-16-2 C27H27F2NO6 499.5
E7820 289483-69-8 C17H12N4O2S 336.36778
Zaurategrast 455264-31-0 C26H25BrN4O3 521.41
Integrin Antagonist 1 (hydrochloride) 1629249-40-6 C29H38ClN5O2 524.1
Integrin Antagonist 1 1629249-33-7 C29H37N5O2 487.64
Lifitegrast 1025967-78-5 C29H24Cl2N2O7S 615.48
Cyclo(RADfK) 756500-23-9 C28H43N9O7 617.7
OSU-T315 1333146-24-9 C30H30F3N5O 533.5873
Integrin Antagonists 27 593274-97-6 C24H20N4O5 444.44
Cyclo(-RGDfK) 161552-03-0 C27H41N9O7 603.67
CWHM-12 1564286-55-0 C26H32BrN5O6 590.47
ATN-161 (trifluoroacetate salt) 904763-27-5 C25H36F3N9O10S 711.67

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Tirofiban

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