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1617-53-4 (Amentoflavone)

1

Identification

Amentoflavone Amentoflavone
Name Amentoflavone
Formula C30H18O10
MW 538.46
CAS No. 1617-53-4
EINECS
Smiles O=C1C=C(C2=CC=C(O)C(C3=C(O)C=C(O)C4=C3OC(C5=CC=C(O)C=C5)=CC4=O)=C2)OC6=C1C(O)=CC(O)=C6
Synonyms 8-(5-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
InChI InChI=1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H
2

Introduction

Amentoflavone is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities.

Background Information

Amentoflavone, a natural flavonoid isolated from the the seed of Ginkgo biloba L, exhibits the activity of antiinflammatory, it inhibits NF-κB/DNA binding activity potently along with inhibition of degradation of IκBα and NF-κB translocation into nucleus ......by BOC Sciences
Amentoflavone is a biflavonoid (bis-apigenin coupled at 8 and 3' positions) constituent of a number of plants including Ginkgo biloba, Chamaecyparis obtusa (hinoki), Hypericum perforatum (St. JohnÂ’s Wort) and Xerophyta plicata. Amentoflavone can interact with many medications by being a potent inhibitor of CYP3A4 and CYP2C9, which are enzymes responsible for the metabolism of some drugs in the body. It is also an inhibitor of human cathepsin B. Amentoflavone has a variety of in vitro activities including antimalarial activity, anticancer activity (which may, at least in part, be mediated by its inhibition of fatty acid synthase), and affinities for opioid receptors (as an antagonist) and the allosteric (benzodiazepine) site on the GABAA receptor as a negative allosteric modulator. ......by MedKoo Biosciences, Inc.
Amentoflavone is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities. ......by Selleck Chemicals LLC
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000011473

Storage condition

Solubility

10 mM in DMSO by CHEMSCENE, LLC
10 mM in DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways Others
Target Others
Research Area Others
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Amentoflavone - Not Found
Amentoflavone - No Development Reported
7

Safety Data of Amentoflavone

Safety Statements : S22;S24/25
WGKGermany : 3
8

Spectral Information

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Suppliers List

Company Price and Availability Country/Region
ALB Technology Limited 20mg/USD218() China
AOBIOUS INC USA
AdooQ BioScience, LLC 5mg/USD150();10mg/USD250();20mg/USD420() USA
Aladdin 25mg/RMB1480();100mg/RMB4999() China
Apexbio Technology LLC USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD70();10mg/USD110() USA
Cayman Chemical Company USA
Chengdu Biopurify Phytochemicals Ltd. China
Extrasynthese Chemical S.A.S. France
MAYA-R 20mg/RMB1300() China
MedChemexpress Co., Ltd. 5mg/USD70();10mg/USD110() USA
MedKoo Biosciences, Inc. USA
Santa Cruz Biotechnology, Inc. 1mg/USD104();5mg/USD405() USA
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD70();10mg/USD110() China
Sigma-Aldrich, Inc. 1mg/USD106();5mg/USD416() USA
Tokyo Chemical Industry Co., Ltd. 20mg/USD185();100mg/USD645() Japan
Wuhan ChemFaces Biochemical Co., Ltd. 20mg/USD218() China
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Related Products

Other Forms of 1617-53-4

Name CAS No Formula MW

Recommended Compounds in Others

Name CAS No Formula MW
(R)-(+)-Etomoxir (sodium salt) 828934-41-4 C15H18ClNaO4 320.74
Dictamine 484-29-7 C12H9NO2 199.21
3,3',5-Triiodo-L-thyronine (sodium) 55-06-1 C15H11I3NNaO4 672.9553
Fabomotizole (hydrochloride) 173352-39-1 C15H22ClN3O2S 343.8721
FPH2 957485-64-2 C14H16ClN5O2S 353.83
α-Tocopherol (phosphate) 38976-17-9 C29H51O5P 510.69
BAMB-4 891025-25-5 C15H12N2O2 252.27
LDN-27219 312946-37-5 C20H16N4O2S2 408.5
ISO-1 478336-92-4 C12H13NO4 235.24
Aurothioglucose 12192-57-3 C6H11AuO5S 392.18
Oxybenzone 131-57-7 C14H12O3 228.24
ITX3 347323-96-0 C22H17N3OS 371.45
Cardiogreen 3599-32-4 C43H47N2NaO6S2 774.96
Skp2 Inhibitor C1 432001-69-9 C18H13BrN2O4S2 465.34
INH1 313553-47-8 C18H16N2OS 308.4
PF6-AM 1268491-69-5 C33H31BO12 630.4
XEN445 1515856-92-4 C18H17F3N2O3 366.33
Disperse Blue 148 52239-04-0 C19H19N5O4S 413.45026
Solvent Blue 35 17354-14-2 C22H26N2O2 350.454
CID-797718 370586-05-3 C12H11NO3 217.2206

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Amentoflavone

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