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6078-17-7 (Berbamine (dihydrochloride))



Berbamine (dihydrochloride) Berbamine (dihydrochloride)
Name Berbamine (dihydrochloride)
Formula C37H42Cl2N2O6
MW 681.6452
CAS No. 6078-17-7
Smiles COC1=C(OC2=CC([[email protected]]3([H])CC(C=C4)=CC=C4O5)=C(CCN3C)C=C2OC)C([[email protected]@]6([H])CC7=CC=C(O)C5=C7)=C(CCN6C)C=C1OC.Cl.Cl
InChI InChI=1S/C37H40N2O6.2ClH/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-31-18-23(8-11-30(31)40)17-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33;;/h6-11,18-21,28-29,40H,12-17H2,1-5H3;2*1H/t28-,29+;;/m0../s1


Berbamine dihydrochloride is an inhibitor of NF-κB activity with remarkable anti-myeloma efficacy.

Background Information

Berbamine hydrochloride and Ver might affect the transport of intracellular Ca~(2+).Berbamine hydrochloride and Ver blockthe calcium-induced contraction of depolarized pig coronary artery strips.It indicate that Berbamine hydrochloride and Ver may competi ......by BOC Sciences
Berbemine is a naturally occurring alkaloid that displays several biological properties. Berbamine potently suppresses liver cancer cell proliferation and induces cancer cell death by targeting Ca²⁺/calmodulin-dependent protein kinase II (CAMKII). Also acts as a novel inhibitor of NF-kappaB activity with remarkable anti-myeloma efficacy. ......by BioVision, Inc.,
Berbamine dihydrochloride is an inhibitor of NF-κB activity with remarkable anti-myeloma efficacy. ......by MedChemexpress Co., Ltd.
Berbamine (BBM) is a natural bisbenzylisoquinoline product isolated from traditional Chinese herbal medicine Berberis amurensis. It is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. ......by Selleck Chemicals LLC
Extracted from berberidis;Store the product in sealed, cool and dry condition ......by Target Molecule Corp.

Protocol(Only for Reference)

Cell Experiment

Animal Experiment


Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000011363

Storage condition

4°C by MedChemexpress Co., Ltd.


10 mM in DMSO by MedChemexpress Co., Ltd.

Mechanism and Indication

Signaling Pathways NF-κB Autophagy
Target Autophagy NF-κB
Research Area Others

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Berbamine (dihydrochloride) - Not Found
Berbamine (dihydrochloride) - No Development Reported

Safety Data of Berbamine (dihydrochloride)


Spectral Information


Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
ALB Technology Limited 20mg/USD70() China
AdooQ BioScience, LLC 1g/USD90() USA
Aladdin 1g/RMB599() China
Apexbio Technology LLC 20mg/USD50() USA
AvaChem Scientific LLC 10mg/USD85();100mg/USD195();1g/USD650() USA
BOC Sciences
Bide Pharmatech Ltd. 1g/USD100();5g/USD300() China
BioVision, Inc., 100mg/USD75();500mg/USD295() USA
CHEMSCENE, LLC 200mg/USD60();500mg/USD96() USA
DC Chemicals 20mg/USD280() China
MAYA-R 20mg/RMB140() China
MedChemexpress Co., Ltd. 200mg/USD60();500mg/USD96() USA
Santa Cruz Biotechnology, Inc. 1g/USD96() USA
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 200mg/USD60();500mg/USD96() China
Sigma-Aldrich, Inc. 1g/USD99() USA
Target Molecule Corp. 5mg/USD24();10mg/USD43();20mg/USD67();100mg/USD177();250mg/USD329() USA
Tianjin Heowns Biochemical Technology Co., Ltd. 250mg/RMB377() China
Wuhan ChemFaces Biochemical Co., Ltd. 20mg/USD70() China

Related Products

Other Forms of 6078-17-7

Name CAS No Formula MW
Berbamine 478-61-5 C37H40N2O6 608.72

Recommended Compounds in Autophagy NF-κB

Name CAS No Formula MW
Pirarubicin (Hydrochloride) 95343-20-7 C32H38ClNO12 664.1
Berberine (chloride) 633-65-8 C20H18ClNO4 371.8142
DMH-1 1206711-16-1 C24H20N4O 380.44
CB-839 1439399-58-2 C26H24F3N7O3S 571.57
H-89 (dihydrochloride) 130964-39-5 C20H22BrCl2N3O2S 519.2826
Shikonin 517-89-5 C16H16O5 288.3
H 89 127243-85-0 C20H20BrN3O2S 446.36
Eupatilin 22368-21-4 C18H16O7 344.32
Isoalantolactone 470-17-7 C15H20O2 232.32
Scutellarein 529-53-3 C15H10O6 286.24
Leonurine 24697-74-3 C14H21N3O5 311.33
Ruxolitinib (S enantiomer) 941685-37-6 C17H18N6 306.37
D-Glucosamine (Hydrochloride) 66-84-2 C6H14ClNO5 215.63
Schizandrin A 61281-38-7 C22H28O6 388.45
Schisandrol B 58546-54-6 C23H28O7 416.46
Schisandrol A 7432-28-2 C24H32O7 432.51
Icaritin 118525-40-9 C21H20O6 368.3799
Bicyclol 118159-48-1 C19H18O9 390.34
Azithromycin 83905-01-5 C38H72N2O12 748.9845
Genistin 529-59-9 C21H20O10 432.38

Recommended Compounds in Same Indication

Name CAS No Formula MW

Route of Synthesis




More Information

Berbamine (dihydrochloride)

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