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15291-77-7 (Ginkgolide B)



Ginkgolide B Ginkgolide B
Name Ginkgolide B
Formula C20H24O10
MW 424.4
CAS No. 15291-77-7
Smiles O[[email protected]@H]1C(C2([[email protected]]3O)[[email protected]](OC3=O)([H])O4)([[email protected]@](O5)([H])C[[email protected]]2C(C)(C)C)C4(C5=O)[[email protected]@](O)([[email protected]@H]6C)[[email protected]@]1([H])OC6=O
Synonyms BN 52021; BN 52051;
InChI InChI=1S/C20H24O10/c1-6-12(23)28-11-9(21)18-8-5-7(16(2,3)4)17(18)10(22)13(24)29-15(17)30-20(18,14(25)27-8)19(6,11)26/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8-,9+,10+,11+,15+,17?,18?,19-,20?/m1/s1


Ginkgolide B is a PAFR antagonist with IC50 of 3.6 μM.

Background Information

Ginkgolide B (BN 52021) is a PAFR antagonist with IC50 of 3.6 μM. ......by AdooQ BioScience, LLC
Ginkgolide B, originally extracted from Ginkgo biloba leaves, is the most potent member of the ginkgolide family of platelet-activating factor receptor (PAF-R) antagonists. PAF is an important mediator of many biological processes including cell proliferation, angiogenesis, inflammatory response regulation, vasodilation, superoxide formation, and platelet aggregation. Mechanistic studies suggest that Ginkgolide B speeds up PAF hydrolysis by promoting PAF-AH I α2 homodimer activity. Additionally ......by Affix Scientific
Description ......by Apexbio Technology LLC
Ginkgolide B is a PAFR antagonist with IC50 of 3.6 μM. ......by BOC Sciences
Ginkgolide B is a GlyR agonist found in Ginkgo. It inhibits ATP release from thrombin-activated platelets, protects neurons against ischemic injury, prevents edema and inflammation, and increases activation of PKA, Ca+2 signaling, and glutamate release. ......by MedKoo Biosciences, Inc.
Ginkgolide B is a PAFR antagonist with IC50 of 3.6 μM. ......by Selleck Chemicals LLC
Extracted from Ginkgo biloba Leaf P.E;Suitability:Ethyl acetate,methanol,ethanol,two sulfoxide;Store the product in sealed,cool and dry condition ......by Target Molecule Corp.
Platelet-activating factor (PAF) receptor antagonist (Ki = 1.3 μM). Inhibits neutrophil degranulation and superoxide production in vitro and inhibits bronchoconstriction and is neuroprotective following oral administration in vivo. ......by Tocris Bioscience Inc.

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

Animal Models Eight-week-old male ApoE−/− mice
Dosage 0.6 mg/day
Formulation PBS
Administration Intragastric administration
Source Selleck Chemicals LLC

Physical and Chemical Properties

Appearance: EBNumber:EB000011313

Storage condition

Up to one week at 4°C or six months at -20°C. by Affix Scientific


10 mM in DMSO by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 85 mg/mL (200.28 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 30% Propylene glycol, 5% Tween 80, 65% D5W10 mg/mL by Selleck Chemicals LLC

Mechanism and Indication

Signaling Pathways Others
Target Others
Research Area Others

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Ginkgolide B - Not Found
Ginkgolide B - No Development Reported

Safety Data of Ginkgolide B

WGKGermany : 3

Spectral Information


Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC USA
Affix Scientific 1g/USD1(In stock);500mg/USD795(In stock) USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
AvaChem Scientific LLC USA
BOC Sciences 20mg/USD198(In stock)
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD43();50mg/USD146() USA
Cayman Chemical Company USA
Chengdu Cogon Bio-tech Co., Ltd. China
MedChemexpress Co., Ltd. 10mg/USD43();50mg/USD146() USA
MedKoo Biosciences, Inc. USA
Nanjing Tcm Institute of Chinese Materia Medica China
Selleck Chemicals LLC 25mg/USD90(In stock);50mg/USD170(In stock);500mg/USD970(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD43();50mg/USD146() China
Target Molecule Corp. 25mg/USD67();50mg/USD119();200mg/USD329() USA
Tocris Bioscience Inc. USA

Related Products

Other Forms of 15291-77-7

Name CAS No Formula MW

Recommended Compounds in Others

Name CAS No Formula MW
(R)-(+)-Etomoxir (sodium salt) 828934-41-4 C15H18ClNaO4 320.74
Dictamine 484-29-7 C12H9NO2 199.21
3,3',5-Triiodo-L-thyronine (sodium) 55-06-1 C15H11I3NNaO4 672.9553
Fabomotizole (hydrochloride) 173352-39-1 C15H22ClN3O2S 343.8721
FPH2 957485-64-2 C14H16ClN5O2S 353.83
α-Tocopherol (phosphate) 38976-17-9 C29H51O5P 510.69
BAMB-4 891025-25-5 C15H12N2O2 252.27
LDN-27219 312946-37-5 C20H16N4O2S2 408.5
ISO-1 478336-92-4 C12H13NO4 235.24
Aurothioglucose 12192-57-3 C6H11AuO5S 392.18
Oxybenzone 131-57-7 C14H12O3 228.24
ITX3 347323-96-0 C22H17N3OS 371.45
Cardiogreen 3599-32-4 C43H47N2NaO6S2 774.96
Skp2 Inhibitor C1 432001-69-9 C18H13BrN2O4S2 465.34
INH1 313553-47-8 C18H16N2OS 308.4
PF6-AM 1268491-69-5 C33H31BO12 630.4
XEN445 1515856-92-4 C18H17F3N2O3 366.33
Disperse Blue 148 52239-04-0 C19H19N5O4S 413.45026
Solvent Blue 35 17354-14-2 C22H26N2O2 350.454
CID-797718 370586-05-3 C12H11NO3 217.2206

Recommended Compounds in Same Indication

Name CAS No Formula MW

Route of Synthesis




More Information

Ginkgolide B

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