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15291-77-7 (Ginkgolide B)

1

Identification

Ginkgolide B Ginkgolide B
Name Ginkgolide B
Formula C20H24O10
MW 424.4
CAS No. 15291-77-7
EINECS
Smiles O[[email protected]@H]1C(C2([[email protected]]3O)[[email protected]](OC3=O)([H])O4)([[email protected]@](O5)([H])C[[email protected]]2C(C)(C)C)C4(C5=O)[[email protected]@](O)([[email protected]@H]6C)[[email protected]@]1([H])OC6=O
Synonyms BN 52021; BN 52051;
InChI InChI=1S/C20H24O10/c1-6-12(23)28-11-9(21)18-8-5-7(16(2,3)4)17(18)10(22)13(24)29-15(17)30-20(18,14(25)27-8)19(6,11)26/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8-,9+,10+,11+,15+,17?,18?,19-,20?/m1/s1
2

Introduction

Ginkgolide B is a PAFR antagonist with IC50 of 3.6 μM.

Background Information

Ginkgolide B (BN 52021) is a PAFR antagonist with IC50 of 3.6 μM. ......by AdooQ BioScience, LLC
Ginkgolide B, originally extracted from Ginkgo biloba leaves, is the most potent member of the ginkgolide family of platelet-activating factor receptor (PAF-R) antagonists. PAF is an important mediator of many biological processes including cell proliferation, angiogenesis, inflammatory response regulation, vasodilation, superoxide formation, and platelet aggregation. Mechanistic studies suggest that Ginkgolide B speeds up PAF hydrolysis by promoting PAF-AH I α2 homodimer activity. Additionally ......by Affix Scientific
Description ......by Apexbio Technology LLC
Ginkgolide B is a PAFR antagonist with IC50 of 3.6 μM. ......by BOC Sciences
Ginkgolide B is a GlyR agonist found in Ginkgo. It inhibits ATP release from thrombin-activated platelets, protects neurons against ischemic injury, prevents edema and inflammation, and increases activation of PKA, Ca+2 signaling, and glutamate release. ......by MedKoo Biosciences, Inc.
Ginkgolide B is a PAFR antagonist with IC50 of 3.6 μM. ......by Selleck Chemicals LLC
Extracted from Ginkgo biloba Leaf P.E;Suitability:Ethyl acetate,methanol,ethanol,two sulfoxide;Store the product in sealed,cool and dry condition ......by Target Molecule Corp.
Platelet-activating factor (PAF) receptor antagonist (Ki = 1.3 μM). Inhibits neutrophil degranulation and superoxide production in vitro and inhibits bronchoconstriction and is neuroprotective following oral administration in vivo. ......by Tocris Bioscience Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

Animal Models Eight-week-old male ApoE−/− mice
Dosage 0.6 mg/day
Formulation PBS
Administration Intragastric administration
Source Selleck Chemicals LLC
4

Physical and Chemical Properties

Appearance: EBNumber:EB000011313

Storage condition

Up to one week at 4°C or six months at -20°C. by Affix Scientific

Solubility

10 mM in DMSO by CHEMSCENE, LLC
10 mM in DMSO by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 85 mg/mL (200.28 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 30% Propylene glycol, 5% Tween 80, 65% D5W10 mg/mL by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways Others
Target Others
Research Area Others
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Ginkgolide B - Not Found
Ginkgolide B - No Development Reported
7

Safety Data of Ginkgolide B

WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AOBIOUS INC USA
AdooQ BioScience, LLC USA
Affix Scientific 1g/USD1(In stock);500mg/USD795(In stock) USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
AvaChem Scientific LLC USA
BOC Sciences 20mg/USD198(In stock)
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD43();50mg/USD146() USA
Cayman Chemical Company USA
Chengdu Cogon Bio-tech Co., Ltd. China
MedChemexpress Co., Ltd. 10mg/USD43();50mg/USD146() USA
MedKoo Biosciences, Inc. USA
Nanjing Tcm Institute of Chinese Materia Medica China
Selleck Chemicals LLC 25mg/USD90(In stock);50mg/USD170(In stock);500mg/USD970(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD43();50mg/USD146() China
Target Molecule Corp. 25mg/USD67();50mg/USD119();200mg/USD329() USA
Tocris Bioscience Inc. USA
10

Related Products

Other Forms of 15291-77-7

Name CAS No Formula MW

Recommended Compounds in Others

Name CAS No Formula MW
(R)-(+)-Etomoxir (sodium salt) 828934-41-4 C15H18ClNaO4 320.74
Dictamine 484-29-7 C12H9NO2 199.21
3,3',5-Triiodo-L-thyronine (sodium) 55-06-1 C15H11I3NNaO4 672.9553
Fabomotizole (hydrochloride) 173352-39-1 C15H22ClN3O2S 343.8721
FPH2 957485-64-2 C14H16ClN5O2S 353.83
α-Tocopherol (phosphate) 38976-17-9 C29H51O5P 510.69
BAMB-4 891025-25-5 C15H12N2O2 252.27
LDN-27219 312946-37-5 C20H16N4O2S2 408.5
ISO-1 478336-92-4 C12H13NO4 235.24
Aurothioglucose 12192-57-3 C6H11AuO5S 392.18
Oxybenzone 131-57-7 C14H12O3 228.24
ITX3 347323-96-0 C22H17N3OS 371.45
Cardiogreen 3599-32-4 C43H47N2NaO6S2 774.96
Skp2 Inhibitor C1 432001-69-9 C18H13BrN2O4S2 465.34
INH1 313553-47-8 C18H16N2OS 308.4
PF6-AM 1268491-69-5 C33H31BO12 630.4
XEN445 1515856-92-4 C18H17F3N2O3 366.33
Disperse Blue 148 52239-04-0 C19H19N5O4S 413.45026
Solvent Blue 35 17354-14-2 C22H26N2O2 350.454
CID-797718 370586-05-3 C12H11NO3 217.2206

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Ginkgolide B

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