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545-47-1 (Lupeol)



Lupeol Lupeol
Name Lupeol
Formula C30H50O
MW 426.72
CAS No. 545-47-1
EINECS 208-889-9
Smiles C[[email protected]@]([[email protected]@]1(C)[[email protected]@]2([H])[[email protected]](CC[[email protected]](O)C3(C)C)(C)[[email protected]@]3([H])CC1)(CC[[email protected]]4(C)[[email protected]]5([H])[[email protected]](C(C)=C)CC4)[[email protected]@]5(CC2)[H]
Synonyms (3beta)-Lup-20(29)-en-3-ol; Fagarasterol; (1R,3aR,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a,5a,5b,8,8,11a-hexamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-ol
InChI InChI=1S/C30H50O/c1-19(2)20-11-14-27(5)17-18-29(7)21(25(20)27)9-10-23-28(6)15-13-24(31)26(3,4)22(28)12-16-30(23,29)8/h20-25,31H,1,9-18H2,2-8H3/t20-,21+,22-,23+,24-,25+,27+,28-,29+,30+/m0/s1


Lupeol is a novel androgen receptor inhibitor.

Background Information

Lupeol is a pentacyclic triterpene that has anti-inflammatory and antioxidant activity. Murine skin studies report that Lupeol inhibits the cutaneous toxicity induced by benzoyl peroxide. Lupeol has been shown to regulate NF-κB and PI3K/Akt pathways, induce Fas-mediated apoptotic death of androgen-sensitive prostate cancer cells, improve the aflatoxin B1-induced peroxidation hepatic damage, and inhibit the Ras signaling pathway. Additionally, Lupeol has been shown to prevent the effects of DMBA ......by Affix Scientific
Lupeol isolated from the flower of Chrysanthemum morifolium. It enhances the radiosensitivity of SMMC-7721 cells in vitro and in vivo. ......by BOC Sciences
Lupeol is a novel androgen receptor inhibitor. ......by MedChemexpress Co., Ltd.
Lupeol is a phytosterol and triterpene widely found in edible fruits, and vegetables. Various in vitro and preclinical animal studies suggest that lupeol has a potential to act as an anti-inflammatory, anti-microbial, anti-protozoal, anti-proliferative, anti-invasive, anti-angiogenic and cholesterol lowering agent. Employing various in vitro and in vivo models, lupeol has also been tested for its therapeutic efficiency against conditions including wound healing, diabetes, cardiovascular disease, kidney disease, and arthritis. ......by MedKoo Biosciences, Inc.
Lupeol is a significant lupane-type triterpene represented in the plant, fungi and animal kingdoms with anticancer, antiprotozoal, chemopreventive and anti-inflammatory properties. ......by Selleck Chemicals LLC
Lupeol is a pentacyclic triterpene that has anti-inflammatory and antioxidant activity. Murine skin studies report that Lupeol inhibits the cutaneous toxicity induced by benzoyl peroxide. Lupeol has been shown to regulate NF-κB and PI3K/Akt pathways,indu ......by Target Molecule Corp.

Protocol(Only for Reference)

Cell Experiment

Animal Experiment


Physical and Chemical Properties

Appearance: EBNumber:EB000011307

Storage condition

Up to one week at 4°C or six months at -20°C. by Affix Scientific


10 mM in DMSO by MedChemexpress Co., Ltd.

Mechanism and Indication

Signaling Pathways Others
Target Androgen Receptor
Research Area

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Lupeol - No Development Reported

Safety Data of Lupeol

RTECS : OK5763000
WGKGermany : 2

Spectral Information


Suppliers List

Company Price and Availability Country/Region
Affix Scientific 500mg/USD600(In stock);1g/USD750(In stock) USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD60();25mg/USD84() USA
Cayman Chemical Company USA
Extrasynthese Chemical S.A.S. France
MedChemexpress Co., Ltd. 10mg/USD60();25mg/USD84() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD60();25mg/USD84() China
Shanghai Yingxuan Chempharm Co., Ltd. China
Target Molecule Corp. 10mg/USD63();20mg/USD94();50mg/USD180() USA

Related Products

Other Forms of 545-47-1

Name CAS No Formula MW

Recommended Compounds in Androgen Receptor

Name CAS No Formula MW
Oxandrolone 53-39-4 C19H30O3 306.44
Testosterone (undecanoate) 5949-44-0 C30H48O3 456.7003
Spironolactone 52-01-7 C24H32O4S 416.57
LGD-4033 1165910-22-4 C14H12F6N2O 338.25
Adrenosterone 382-45-6 C19H24O3 300.39
Triptophenolide 74285-86-2 C20H24O3 312.4
Epiandrosterone 481-29-8 C19H30O2 290.44
3,3'-Diindolylmethane 1968-05-4 C17H14N2 246.31
Boldenone Undecylenate 13103-34-9 C30H44O3 452.67
Testosterone 58-22-0 C19H28O2 288.42
Cyproterone (acetate) 427-51-0 0.0
GLPG0492 1215085-92-9 C19H14F3N3O3 389.328
N-desmethyl Enzalutamide 1242137-16-1 C20H14F4N4O2S 450.41
AZD3514 1240299-33-5 C25H32F3N7O2 519.56
ARN-509 956104-40-8 C21H15F4N5O2S 477.43
DHEA 53-43-0 C19H28O2 288.42
RAD140 1182367-47-0 C20H16ClN5O2 393.83
Cortexolone 17 alpha-propionate 19608-29-8 C24H34O5 402.5238
BMS-564929 627530-84-1 C14H12ClN3O3 305.72
MK-0773 606101-58-0 C27H34FN5O2 479.59

Recommended Compounds in Same Indication

Name CAS No Formula MW

Route of Synthesis



Protocol Reference


More Information


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