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1127442-82-3 (IWR-1)

1

Identification

IWR-1 IWR-1
Name IWR-1
Formula C25H19N3O3
MW 409.44
CAS No. 1127442-82-3
EINECS
Smiles O=C(NC1=C2N=CC=CC2=CC=C1)C3=CC=C(N(C([[email protected]]4([H])[[email protected]](C5)([H])C=C[[email protected]]5([H])[[email protected]]64[H])=O)C6=O)C=C3
Synonyms endo-IWR 1;IWR-1-endo;IWR1;IWR 1; 4-((3aR,4S,7R,7aS)-1,3-dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)-N-(quinolin-8-yl)benzamide
InChI InChI=1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,20-21H,13H2,(H,27,29)/t16-,17+,20-,21+
2

Introduction

IWR-1(IWR-1-endo) is a novel small molecule Wnt signaling by stabilizing the Axin destruction complex with an EC50 of 0.2 uM. IC50 value: 0.2 uM (EC50) [1] Target: Wnt signaling During NSPC differentiation, MIF increased the activity of β-galactosidase that responds to Wnt/β-catenin signaling.

Background Information

IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. ......by AbMole BioScience
Potent and reversible cell permeable Wnt pathway signaling inhibitor [1, 2, 4, 5]. Inhibits Wnt-induced accumulation of β-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, CK1 and GSK-3β. Stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK-3β. Tankyrase-1 (TNKS1/PARP5a) and Tankyrase-2 (TNKS2/PARP5b) inhibitor (in vitro auto-PARsylation assay) [3, 6]. ......by Adipogen Corporation
IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription.
......by AdooQ BioScience, LLC
Description ......by Apexbio Technology LLC
IWR-1 is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, and induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. ......by MedChemexpress Co., Ltd.
IWR-1, also known as IWR-1-endo, is a an inhibitor of the Wnt signaling cascade through inhibiting TNKSs, binding only to the adenosine-binding site. IWR-1 inhibits epithelial-mesenchymal transition of colorectal cancer cells through suppressing Wnt/β-catenin signaling as well as survivin expression. IWR-1 inhibits cell proliferation and EMT even in the presence of TNF-α-induced cancer cell stimulation. IWR-1 also significantly suppressed cell migration, invasion, and matrix metalloproteinase activities of CRC cell lines. IWR-1 provides EMT reversal effects by directly suppressing survivin expression. ......by MedKoo Biosciences, Inc.
A potent inhibitor of Wnt signaling with EC50 of 0.2 uM; induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes; PARP inhibitor. ......by ProbeChem
IWR-1-endo is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. ......by Selleck Chemicals LLC
IWR-1-endo is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. ......by Target Molecule Corp.
Inhibitor of Wnt signaling. Induces an increase in Axin2 protein levels; promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. Negative Control also available. ......by Tocris Bioscience Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000010604

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 30 mg/mL (73.27 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways Stem Cell/Wnt
Target Wnt
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
IWR-1 - No Development Reported
7

Safety Data of IWR-1

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AbMole BioScience 10mg/USD90(In stock) USA
Adipogen Corporation USA
AdooQ BioScience, LLC 10mg/USD56() USA
Apexbio Technology LLC 10mgmg/USD70(In stock) USA
Ark Pharm, Inc. USA
BOC Sciences 25mg/USD198(In stock)
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD60();10mg/USD92() USA
Carbosynth Limited 5mg/USD149()
Cayman Chemical Company 5mg/USD54() USA
Lancrix Chemicals. 5mg/USD50() China
MedChemexpress Co., Ltd. 5mg/USD60();10mg/USD92() USA
MedKoo Biosciences, Inc. USA
ProbeChem
Selleck Chemicals LLC 10mg/USD110(In stock);25mg/USD250(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD60();10mg/USD92() China
Sigma-Aldrich, Inc. 5mg/USD72() USA
Target Molecule Corp. 2mg/USD42();5mg/USD69();10mg/USD115();25mg/USD168();50mg/USD242() USA
Tocris Bioscience Inc. 10mg/USD129() USA
10

Related Products

Other Forms of 1127442-82-3

Name CAS No Formula MW

Recommended Compounds in Wnt

Name CAS No Formula MW
Berberine (chloride) 633-65-8 C20H18ClNO4 371.8142
iCRT 14 677331-12-3 C21H17N3O2S 375.44
IWP-2 686770-61-6 C22H18N4O2S3 466.6
FH535 108409-83-2 C13H10Cl2N2O4S 361.2
KY02111 1118807-13-8 C18H17ClN2O3S 376.86
Wnt-C59 1243243-89-1 C25H21N3O 379.45
Salinomycin 53003-10-4 C42H69NaO11 772.98
Berberine (hydrochloride) 633-65-8 0.0
IQ 1 331001-62-8 C21H22N4O2 362.42
Pamidronic acid 40391-99-9 C3H11NO7P2 235.07
Triptonide 38647-11-9 C20H22O6 358.39
ICG-001 847591-62-2 C33H32N4O4 548.63
Hexachlorophene 70-30-4 C13H6Cl6O2 406.9
BML-284 853220-52-7 C19H18N4O3 350.37
JW74 863405-60-1 C24H20N6O2S 456.52
ETC-159 1638250-96-0 C19H17N7O3 391.38
Cardiogenol C (hydrochloride) 1049741-55-0 C13H17ClN4O2 296.75
CCT251545 1661839-45-7 C23H24ClN5O 421.92
Pyrvinium pamoate 3546-41-6 C26H28N3 . 1/2 C23H14O6 575.7
PNU-74654 113906-27-7 C19H16N2O3 320.34194

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

IWR-1

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