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313553-47-8 (INH1)

1

Identification

INH1 INH1
Name INH1
Formula C18H16N2OS
MW 308.4
CAS No. 313553-47-8
EINECS
Smiles O=C(NC1=NC(C2=CC=C(C)C=C2C)=CS1)C3=CC=CC=C3
Synonyms IBT13131; N-(4-(2,4-dimethylphenyl)thiazol-2-yl)benzamide
InChI InChI=1S/C18H16N2OS/c1-12-8-9-15(13(2)10-12)16-11-22-18(19-16)20-17(21)14-6-4-3-5-7-14/h3-11H,1-2H3,(H,19,20,21)
2

Introduction

INH1 is a small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. IC50 value: 10-21 uM (GI50 in human breast cancer cell lines) [1] Target: Hec1 inhibitor Treating cells with INH1 triggered reduction of kinetochore-bound Hec1 as well as global Nek2 protein level, consequently leading to metaphase chromosome misalignment, spindle aberrancy, and eventual cell death.

Background Information

INH1 is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction. ......by BOC Sciences
INH1 is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000010219

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Others
Target Others
Research Area Cancer
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
INH1 - Not Found
INH1 - No Development Reported
7

Safety Data of INH1

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD98();50mg/USD306() USA
EMD Millipore 10mg/USD451() USA
MedChemexpress Co., Ltd. 10mg/USD98();50mg/USD306() USA
Santa Cruz Biotechnology, Inc. 10mg/USD149() USA
Selleck Chemicals LLC 10mg/USD122(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD98();50mg/USD306() China
Target Molecule Corp. 10mg/USD78();25mg/USD150();50mg/USD225() USA
Tocris Bioscience Inc. 10mg/USD155() USA
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Related Products

Other Forms of 313553-47-8

Name CAS No Formula MW

Recommended Compounds in Others

Name CAS No Formula MW
(R)-(+)-Etomoxir (sodium salt) 828934-41-4 C15H18ClNaO4 320.74
Dictamine 484-29-7 C12H9NO2 199.21
3,3',5-Triiodo-L-thyronine (sodium) 55-06-1 C15H11I3NNaO4 672.9553
Fabomotizole (hydrochloride) 173352-39-1 C15H22ClN3O2S 343.8721
FPH2 957485-64-2 C14H16ClN5O2S 353.83
α-Tocopherol (phosphate) 38976-17-9 C29H51O5P 510.69
BAMB-4 891025-25-5 C15H12N2O2 252.27
LDN-27219 312946-37-5 C20H16N4O2S2 408.5
ISO-1 478336-92-4 C12H13NO4 235.24
Aurothioglucose 12192-57-3 C6H11AuO5S 392.18
Oxybenzone 131-57-7 C14H12O3 228.24
ITX3 347323-96-0 C22H17N3OS 371.45
Cardiogreen 3599-32-4 C43H47N2NaO6S2 774.96
Skp2 Inhibitor C1 432001-69-9 C18H13BrN2O4S2 465.34
PF6-AM 1268491-69-5 C33H31BO12 630.4
XEN445 1515856-92-4 C18H17F3N2O3 366.33
Disperse Blue 148 52239-04-0 C19H19N5O4S 413.45026
Solvent Blue 35 17354-14-2 C22H26N2O2 350.454
CID-797718 370586-05-3 C12H11NO3 217.2206
CP-640186 (hydrochloride) 591778-70-0 C30H36ClN3O3 522.08

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

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More Information

INH1

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