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677331-12-3 (iCRT 14)

1

Identification

iCRT 14 iCRT 14
Name iCRT 14
Formula C21H17N3O2S
MW 375.44
CAS No. 677331-12-3
EINECS
Smiles O=C(S/1)N(C2=CC=CC=C2)C(C1=CC3=C(C)N(C(C)=C3)C4=CN=CC=C4)=O
Synonyms iCRT14;iCRT-14; (Z)-5-((2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl)methylene)-3-phenylthiazolidine-2,4-dione
InChI InChI=1S/C21H17N3O2S/c1-14-11-16(15(2)23(14)18-9-6-10-22-13-18)12-19-20(25)24(21(26)27-19)17-7-4-3-5-8-17/h3-13H,1-2H3/b19-12-
2

Introduction

iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). IC50 value: 40.3 nM [1] Target: Wnt inhibitor Thought to directly influence the interaction between β-catenin and TCF4.

Background Information

iCRT 14 is a novel potent inhibitor of beta-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). ......by AdooQ BioScience, LLC
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT). It is thought to directly influence the interaction between β-catenin and TCF4. It also induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines. ......by BOC Sciences
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT), with IC50 of 40.3 nM against Wnt responsive STF16 luciferase. ......by MedChemexpress Co., Ltd.
iCRT14 is a potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling in a reporter assay in vitro (IC50 = 40.3 nM). It inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) in quantitative reporter assays of β-catenin/Tcf4 binding (Ki = 53.51 μM). ......by MedKoo Biosciences, Inc.
Potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between β-catenin and TCF4. Induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000010178

Storage condition

Solubility

Soluble to 75 mM in DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Stem Cell/Wnt
Target Wnt
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
iCRT 14 - Not Found
iCRT 14 - No Development Reported
7

Safety Data of iCRT 14

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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC USA
Apexbio Technology LLC 10mg/USD133() USA
Ark Pharm, Inc. USA
Axon Medchem BV 10mg/USD162(In Stock) Netherlands
BOC Sciences 25mg/USD298(In stock)
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD84();10mg/USD144() USA
Carbosynth Limited 5mg/USD140()
Cayman Chemical Company USA
Hello Bio Inc. 10mg/USD128() USA
MedChemexpress Co., Ltd. 5mg/USD84();10mg/USD144() USA
MedKoo Biosciences, Inc. USA
Santa Cruz Biotechnology, Inc. 10mg/USD179() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD84();10mg/USD144() China
Tocris Bioscience Inc. 10mg/USD185() USA
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Related Products

Other Forms of 677331-12-3

Name CAS No Formula MW

Recommended Compounds in Wnt

Name CAS No Formula MW
Berberine (chloride) 633-65-8 C20H18ClNO4 371.8142
IWR-1 1127442-82-3 C25H19N3O3 409.44
IWP-2 686770-61-6 C22H18N4O2S3 466.6
FH535 108409-83-2 C13H10Cl2N2O4S 361.2
KY02111 1118807-13-8 C18H17ClN2O3S 376.86
Wnt-C59 1243243-89-1 C25H21N3O 379.45
Salinomycin 53003-10-4 C42H69NaO11 772.98
Berberine (hydrochloride) 633-65-8 0.0
IQ 1 331001-62-8 C21H22N4O2 362.42
Pamidronic acid 40391-99-9 C3H11NO7P2 235.07
Triptonide 38647-11-9 C20H22O6 358.39
ICG-001 847591-62-2 C33H32N4O4 548.63
Hexachlorophene 70-30-4 C13H6Cl6O2 406.9
BML-284 853220-52-7 C19H18N4O3 350.37
JW74 863405-60-1 C24H20N6O2S 456.52
ETC-159 1638250-96-0 C19H17N7O3 391.38
Cardiogenol C (hydrochloride) 1049741-55-0 C13H17ClN4O2 296.75
CCT251545 1661839-45-7 C23H24ClN5O 421.92
Pyrvinium pamoate 3546-41-6 C26H28N3 . 1/2 C23H14O6 575.7
PNU-74654 113906-27-7 C19H16N2O3 320.34194

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

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References

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More Information

iCRT 14

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