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958295-17-5 (AGN 196996)

1

Identification

AGN 196996 AGN 196996
Name AGN 196996
Formula C24H20BrNO5
MW 482.32
CAS No. 958295-17-5
EINECS
Smiles BrC1=CC(C(NC2=CC=C(C(O)=O)C=C2)=O)=CC(C(C3=CC=C(C)C=C3)=O)=C1OCC
Synonyms AGN196996;AGN-196996; 4-(3-bromo-4-ethoxy-5-(4-methylbenzoyl)benzamido)benzoic acid
InChI InChI=1S/C24H20BrNO5/c1-3-31-22-19(21(27)15-6-4-14(2)5-7-15)12-17(13-20(22)25)23(28)26-18-10-8-16(9-11-18)24(29)30/h4-13H,3H2,1-2H3,(H,26,28)(H,29,30)
2

Introduction

AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). IC50 value: 2 nM(Ki) Target: RARα antagonist AGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists.

Background Information

AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). ......by AdooQ BioScience, LLC
AGN 196996 is a potent and selective antagonist of RARα. It has been reported to selectively bind to RARs (retinoic acid receptors) for RARα, RARβ and RARγ. It can inhibit the gene transcription activity which induced by ATRA and other RAR agonists. It s ......by BOC Sciences
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000010155

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Metabolic Enzyme/Protease
Target RAR/RXR
Research Area Cancer
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
AGN 196996 - No Development Reported
7

Safety Data of AGN 196996

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC USA
Apexbio Technology LLC 5mg/USD332() USA
Ark Pharm, Inc. USA
BOC Sciences
CHEMSCENE, LLC 5mg/USD850();10mg/USD1200() USA
MedChemexpress Co., Ltd. 5mg/USD850();10mg/USD1200() USA
Santa Cruz Biotechnology, Inc. USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD850();10mg/USD1200() China
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Related Products

Other Forms of 958295-17-5

Name CAS No Formula MW

Recommended Compounds in RAR/RXR

Name CAS No Formula MW
AGN 205728 859498-05-8 C29H27NO3 437.53
AGN 194310 229961-45-9 C28H24O2S 424.55
Acitretin (sodium) 925701-88-8 C21H25NaO3 348.41
Acitretin 55079-83-9 C21H26O3 326.43
Adapalene (sodium salt) 911110-93-5 C28H27NaO3 434.5
Adapalene 106685-40-9 C28H28O3 412.52
TTNPB 71441-28-6 C24H28O2 348.48
Magnolol 528-43-8 C18H18O2 266.33
Tazarotene 118292-40-3 C21H21NO2S 351.46
Fenretinide 65646-68-6 C26H33NO2 391.55
LG 100268 153559-76-3 C24H29NO2 363.49
Isotretinoin 4759-48-2 C20H28O2 300.44
Palovarotene 410528-02-8 C27H30N2O2 414.54
Retinoic acid 302-79-4 C20H28O2 300.44
AM580 102121-60-8 C22H25NO3 351.44
(R)-Flurbiprofen 51543-40-9 C15H13FO2 244.2609
Tamibarotene 94497-51-5 C22H25NO3 351.44
Bexarotene 153559-49-0 C24H28O2 348.48
AGN 195183 367273-07-2 C22H22ClF2NO4 437.86
AR7 80306-38-3 C15H12ClNO 0.0

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

AGN 196996

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