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12192-57-3 (Aurothioglucose)

1

Identification

Aurothioglucose Aurothioglucose
Name Aurothioglucose
Formula C6H11AuO5S
MW 392.18
CAS No. 12192-57-3
EINECS 235-365-7
Smiles O[[email protected]@H]1[[email protected]@H](CO)OC(S[Au])[[email protected]](O)[[email protected]]1O
Synonyms Gold thioglucose; (1-D-Glucosylthio)gold; (1-Thio-D-glucopyranosato)gold; (alpha-D-Glucopyranosylthio)gold; (((3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)thio)gold
InChI InChI=1S/C6H12O5S.Au/c7-1-2-3(8)4(9)5(10)6(12)11-2;/h2-10,12H,1H2;/q;+1/p-1/t2-,3-,4+,5-,6?;/m1./s1
2

Introduction

Aurothioglucose (Gold thioglucose) is a well known active-site inhibitor of TrxR1, inhibited TrxR1 activity in HeLa cell cytosol but had no effect on the viability of the cells. IC50 value: Target: TrxR1 in vitro: Trx1 redox state and ROS generation were measured in cells exposed to the TrxR1 inhibitors aurothioglucose (ATG) and monomethylarsonous acid (MMA(III)) and in cells depleted of TrxR1 activity by siRNA knock down [1]. in vivo: Adult mice received a single intratracheal dose of 0.375 μg/g lipopolysaccharide (LPS) 12 h before a single intraperitoneal injection of 25 mg/kg ATG.

Background Information

Aurothioglucose is used in the treatment of rheumatoid arthritis and psoriasis. ......by BOC Sciences
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB000010112

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Others
Target Others
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Aurothioglucose - No Development Reported
Aurothioglucose - Launched
7

Safety Data of Aurothioglucose

Hazard Symbols : Xn
Risk Statements : 42/43
Safety Statements : 22-36/37-45
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
BOC Sciences
CHEMSCENE, LLC 5mg/USD156();10mg/USD252() USA
Hubei Xiangyun Group China
Hubei Xiangyun Group CHINA
MedChemexpress Co., Ltd. 5mg/USD156();10mg/USD252() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD156();10mg/USD252() China
Spectrum Chemical Mfg. Corp. USA
10

Related Products

Other Forms of 12192-57-3

Name CAS No Formula MW

Recommended Compounds in Others

Name CAS No Formula MW
(R)-(+)-Etomoxir (sodium salt) 828934-41-4 C15H18ClNaO4 320.74
Dictamine 484-29-7 C12H9NO2 199.21
3,3',5-Triiodo-L-thyronine (sodium) 55-06-1 C15H11I3NNaO4 672.9553
Fabomotizole (hydrochloride) 173352-39-1 C15H22ClN3O2S 343.8721
FPH2 957485-64-2 C14H16ClN5O2S 353.83
α-Tocopherol (phosphate) 38976-17-9 C29H51O5P 510.69
BAMB-4 891025-25-5 C15H12N2O2 252.27
LDN-27219 312946-37-5 C20H16N4O2S2 408.5
ISO-1 478336-92-4 C12H13NO4 235.24
Oxybenzone 131-57-7 C14H12O3 228.24
ITX3 347323-96-0 C22H17N3OS 371.45
Cardiogreen 3599-32-4 C43H47N2NaO6S2 774.96
Skp2 Inhibitor C1 432001-69-9 C18H13BrN2O4S2 465.34
INH1 313553-47-8 C18H16N2OS 308.4
PF6-AM 1268491-69-5 C33H31BO12 630.4
XEN445 1515856-92-4 C18H17F3N2O3 366.33
Disperse Blue 148 52239-04-0 C19H19N5O4S 413.45026
Solvent Blue 35 17354-14-2 C22H26N2O2 350.454
CID-797718 370586-05-3 C12H11NO3 217.2206
CP-640186 (hydrochloride) 591778-70-0 C30H36ClN3O3 522.08

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Aurothioglucose

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