• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

1431985-92-0 (K 02288)

1

Identification

K 02288 K 02288
Name K 02288
Formula C20H20N2O4
MW 352.38
CAS No. 1431985-92-0
EINECS
Smiles OC1=CC=CC(C2=CC(C3=CC(OC)=C(OC)C(OC)=C3)=C(N)N=C2)=C1
Synonyms K02288;K-02288; 3-(6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenol
InChI InChI=1S/C20H20N2O4/c1-24-17-9-13(10-18(25-2)19(17)26-3)16-8-14(11-22-20(16)21)12-5-4-6-15(23)7-12/h4-11,23H,1-3H3,(H2,21,22)
2

Introduction

Background Information

K02288 is a novel small molecule inhibitor of ALK1/2/3/6 with IC50s of 1.8/1.1/34.4/6.3 nM; specific for ALK1,2,3,6 over ALK4,5; inhibitor of BMP signaling. IC50 value: 1.8/1.1/34.4/6.3 nM(ALK1/2/3/6) [1] Tarhet: ALK2 inhibitor K02288 is a highly selective 2-aminopyridinebased inhibitor K02288 with in vitro activity against ALK2 at low nanomolar concentrations similar to the current lead compound LDN-193189. K02288 specifically inhibited the BMP-induced Smad pathway without affecting TGF-b signaling and induced dorsalization of zebrafish embryos. ......by MedChemexpress Co., Ltd.
K02288 is a novel small molecule inhibitor of ALK1/2/3/6 with IC50s of 1.8/1.1/34.4/6.3 nM; specific for ALK1,2,3,6 over ALK4,5; inhibitor of BMP signaling. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000010100

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

DMSO > 58 mg/ml by CHEMSCENE, LLC
DMSO > 58 mg/ml by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways TGF-beta/Smad
Target TGF-β Receptor
Research Area Others
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
K 02288 - No Development Reported
7

Safety Data of K 02288

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AOBIOUS INC 1mg/USD20();5mg/USD85() USA
CHEMSCENE, LLC USA
Cayman Chemical Company 1mg/USD29() USA
MedChemexpress Co., Ltd. 10mg/USD135(In stock);50mg/USD450(In stock) USA
Santa Cruz Biotechnology, Inc. 5mg/USD250() USA
Shanghai Haoyuan Chemexpress Co., Ltd. China
Sigma-Aldrich, Inc. 5mg/USD109() USA
Target Molecule Corp. 5mg/USD98();10mg/USD129();25mg/USD218();50mg/USD398() USA
Tocris Bioscience Inc. 10mg/USD205() USA
10

Related Products

Other Forms of 1431985-92-0

Name CAS No Formula MW

Recommended Compounds in TGF-β Receptor

Name CAS No Formula MW
ML347 1062368-49-3 C22H16N4O 352.39
DMH-1 1206711-16-1 C24H20N4O 380.44
LDN-212854 1432597-26-6 C25H22N6 406.48
SB-505124 (hydrochloride) 356559-13-2 C20H22ClN3O2 371.86
A 77-01 607737-87-1 C18H14N4 286.33
SB-505124 694433-59-5 C20H21N3O2 335.4
LY-364947 396129-53-6 C17H12N4 272.3
LDN193189 (Hydrochloride) 1062368-62-0 C25H26Cl4N6 552.33
SD-208 627536-09-8 C17H10ClFN6 352.75
RepSox 446859-33-2 C17H13N5 287.32
LDN193189 1062368-24-4 C25H22N6 406.48
A 83-01 909910-43-6 C25H19N5S 421.52
LY2109761 700874-71-1 C26H27N5O2 441.52
LY2157299 700874-72-2 C22H19N5O 369.42
GW788388 452342-67-5 C25H23N5O2 425.48
SB 525334 356559-20-1 C21H21N5 343.42
SB-431542 301836-41-9 C22H16N4O3 384.39
EW-7197 1352608-82-2 C22H18FN7 399.42
R-268712 879487-87-3 C20H18FN5O 363.39
ITD-1 1099644-42-4 C27H29NO3 415.52

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

K 02288

Tags: buy 1431985-92-0 IC50 | 1431985-92-0 price | 1431985-92-0 cost | 1431985-92-0 solubility | 1431985-92-0 purchase | 1431985-92-0 manufacturer | 1431985-92-0 research buy | 1431985-92-0 order | 1431985-92-0 MSDS | 1431985-92-0 chemical structure | 1431985-92-0 Storage condition | 1431985-92-0 molecular weight | 1431985-92-0 mw | 1431985-92-0 datasheet | 1431985-92-0 supplier | 1431985-92-0 cell line | 1431985-92-0 NMR | 1431985-92-0 MS | 1431985-92-0 IR | 1431985-92-0 solubility | 1431985-92-0 Safe information | 1431985-92-0 Qc and Spectral Information | 1431985-92-0 Clinical Information | 1431985-92-0 Clinical Trial | 1431985-92-0 Route of Synthesis | 1431985-92-0 storage condition | 1431985-92-0 diseases and conditions | 1431985-92-0 flash point | 1431985-92-0 boiling point | 1431985-92-0 melting point | 1431985-92-0 storage condition | 1431985-92-0 brand