• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

1431985-92-0 (K02288)

1

Identification

K02288 K02288
Name K02288
Formula C20H20N2O4
MW 352.3838
CAS No. 1431985-92-0
EINECS
Smiles OC1=CC=CC(C2=CC(C3=CC(OC)=C(OC)C(OC)=C3)=C(N)N=C2)=C1
Synonyms K-02288; K 02288; K 02288.
InChI InChI=1S/C20H20N2O4/c1-24-17-9-13(10-18(25-2)19(17)26-3)16-8-14(11-22-20(16)21)12-5-4-6-15(23)7-12/h4-11,23H,1-3H3,(H2,21,22)
2

Introduction

K02288 is a potent inhibitor of ALK, and inhibits ALK1/2/3/6 with IC50s of 1.8/1.1/34.4/6.3 nM; less potent against ALK4/5, with IC50s of 302 nM and 321 nM.

Background Information

Novel highly selective inhibitor of the bone morphogenetic protein (BMP) receptor kinase ALK2 (ACVR1) ......by AOBIOUS INC
K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA. ......by AbMole BioScience
K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6.

......by AdooQ BioScience, LLC
Description ......by Apexbio Technology LLC
K02288 is a highly selective 2-aminopyridinebased inhibitor K02288 with in vitro activity against ALK2 at low nanomolar concentrations similar to the current lead compound LDN-193189. K02288 specifically inhibited the BMP-induced Smad pathway without affe ......by BOC Sciences
K02288 is a potent inhibitor of ALK, and inhibits ALK1/2/3/6 with IC50s of 1.8/1.1/34.4/6.3 nM; K02288 is less potent against ALK4/5, with IC50s of 302 nM and 321 nM. ......by MedChemexpress Co., Ltd.
K02288 is a potent inhibitor of BMP signaling. K02288 has in vitro activity against ALK2 at low nanomolar concentrations similar to the current lead compound LDN-193189. K02288 specifically inhibited the BMP-induced Smad pathway without affecting TGF-β signaling and induced dorsalization of zebrafish embryos. ......by MedKoo Biosciences, Inc.
K02288 is a potent, selective inhibitor of BMP signaling with IC50 of 1.8/1.1/34.4/6.3 nM for ALK/1/2/3/6, displays 300-fold selectivity for ALK2 over the TGF-β receptor ALK5 and ALK4; also wekaly inhibits type II BMP receptor ActRIIA (IC50=220 nM); specifically inhibits the BMP-induced Smad pathway without affecting TGF-β signaling and induces dorsalization of zebrafish embryos; inhibits BMP9-induced phosphorylation of SMAD1/5/8 in HUVECs to reduce both the SMAD and the Notch-dependent transcriptional responses, inhibits functional angiogenesis. ......by ProbeChem
K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA. ......by Selleck Chemicals LLC
K02288 is a novel small molecule inhibitor of ALK1/2/3/6 with IC50s of 1.8/1.1/34.4/6.3 nM; specific for ALK1,2,3,6 over ALK4,5; inhibitor of BMP signaling. ......by Target Molecule Corp.
Potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC50 values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). Reduces BMP4-induced Smad1/5/8 phosphorylation in vitro (IC50 = 100 nM) and induces dorsalization of zebrafish embryos. ......by Tocris Bioscience Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000010100

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

DMSO > 58 mg/ml by CHEMSCENE, LLC
DMSO > 58 mg/ml by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways TGF-beta/Smad
Target TGF-β Receptor
Research Area Others
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
K02288 - No Development Reported
7

Safety Data of K02288

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AOBIOUS INC 1mg/USD20();5mg/USD85() USA
AbMole BioScience USA
AdooQ BioScience, LLC USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
Astatech, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD162();50mg/USD540() USA
Cayman Chemical Company 1mg/USD29() USA
MedChemexpress Co., Ltd. 10mg/USD162();50mg/USD540() USA
MedKoo Biosciences, Inc. USA
ProbeChem
Santa Cruz Biotechnology, Inc. 5mg/USD250() USA
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD162();50mg/USD540() China
Sigma-Aldrich, Inc. 5mg/USD109() USA
Target Molecule Corp. 5mg/USD98();10mg/USD129();25mg/USD218();50mg/USD398() USA
Tocris Bioscience Inc. 10mg/USD205() USA
10

Related Products

Other Forms of 1431985-92-0

Name CAS No Formula MW

Recommended Compounds in TGF-β Receptor

Name CAS No Formula MW
ML347 1062368-49-3 C22H16N4O 352.39
DMH-1 1206711-16-1 C24H20N4O 380.44
LDN-212854 1432597-26-6 C25H22N6 406.48
SB-505124 (hydrochloride) 356559-13-2 C20H22ClN3O2 371.86
A 77-01 607737-87-1 C18H14N4 286.33
SB-505124 694433-59-5 C20H21N3O2 335.4
LY-364947 396129-53-6 C17H12N4 272.3
LDN193189 (Hydrochloride) 1062368-62-0 C25H26Cl4N6 552.33
SD-208 627536-09-8 C17H10ClFN6 352.75
RepSox 446859-33-2 C17H13N5 287.32
LDN193189 1062368-24-4 C25H22N6 406.48
A 83-01 909910-43-6 C25H19N5S 421.52
LY2109761 700874-71-1 C26H27N5O2 441.52
LY2157299 700874-72-2 C22H19N5O 369.42
GW788388 452342-67-5 C25H23N5O2 425.48
SB 525334 356559-20-1 C21H21N5 343.42
SB-431542 301836-41-9 C22H16N4O3 384.39
EW-7197 1352608-82-2 C22H18FN7 399.42
R-268712 879487-87-3 C20H18FN5O 363.39
ITD-1 1099644-42-4 C27H29NO3 415.52

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

K02288

Tags: buy 1431985-92-0 IC50 | 1431985-92-0 price | 1431985-92-0 cost | 1431985-92-0 solubility | 1431985-92-0 purchase | 1431985-92-0 manufacturer | 1431985-92-0 research buy | 1431985-92-0 order | 1431985-92-0 MSDS | 1431985-92-0 chemical structure | 1431985-92-0 Storage condition | 1431985-92-0 molecular weight | 1431985-92-0 mw | 1431985-92-0 datasheet | 1431985-92-0 supplier | 1431985-92-0 cell line | 1431985-92-0 NMR | 1431985-92-0 MS | 1431985-92-0 IR | 1431985-92-0 solubility | 1431985-92-0 Safe information | 1431985-92-0 Qc and Spectral Information | 1431985-92-0 Clinical Information | 1431985-92-0 Clinical Trial | 1431985-92-0 Route of Synthesis | 1431985-92-0 storage condition | 1431985-92-0 diseases and conditions | 1431985-92-0 flash point | 1431985-92-0 boiling point | 1431985-92-0 melting point | 1431985-92-0 storage condition | 1431985-92-0 brand