• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

1536200-31-3 (GNE-9605)

1

Identification

GNE-9605 GNE-9605
Name GNE-9605
Formula C17H20ClF4N7O
MW 449.83
CAS No. 1536200-31-3
EINECS
Smiles FC(C1=CN=C(NC2=C(Cl)N([[email protected]@H]3[[email protected]@H](F)CN(C4COC4)CC3)N=C2)N=C1NC)(F)F
Synonyms GNE 9605;GNE9605;N2-(5-chloro-1-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine; N2-(5-chloro-1-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine
InChI InChI=1S/C17H20ClF4N7O/c1-23-15-10(17(20,21)22)4-24-16(27-15)26-12-5-25-29(14(12)18)13-2-3-28(6-11(13)19)9-7-30-8-9/h4-5,9,11,13H,2-3,6-8H2,1H3,(H2,23,24,26,27)/t11-,13-/m0/s1
2

Introduction

GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki and IC50 of 2 nM and 19 nM, respectively.

Background Information

GNE-9605 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. Leucine-rich repeat kinase 2 (LRRK2) has drawn significant interest in the neuroscience research community because it is one of the most compelling targets for a potential disease-modifying Parkinson's disease therapy. ......by AbMole BioScience
GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki and IC50 of 2 nM and 19 nM, respectively. ......by AdooQ BioScience, LLC
GNE-9605 retained excellent predicted human metabolic stability when assayed in human liver microsomes and hepatocytes. In addition, no reversible or time-dependent inhibition of any of the major CYP isoforms was observed. The demonstrated metabolic stabi ......by BOC Sciences
GNE-9605 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. Leucine-rich repeat kinase 2 (LRRK2) has drawn significant interest in the neuroscience research community because it is one of the most compelling targets for a potential disease-modifying Parkinson's disease therapy. ......by MedKoo Biosciences, Inc.
GNE-9605 is a highly potent, selective, brain penetrant LRRK2 inhibitor with Ki of 2 nM, pLRRK2 IC50 of 19 nM; dispalys excellent selectivity against 178-membered Invitrogen kinase panel, as well as a representative panel of receptors and ion channels; demonstrates robust concentration-dependent inhibition of LRRK2 Ser1292 autophosphorylation (IC50=20 nM) in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation. ......by ProbeChem
GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki and IC50 of 2 nM and 19 nM, respectively. ......by Selleck Chemicals LLC
GNE-9605 is a highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 19 nM. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000010086

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

DMSO 60 mg/ml by CHEMSCENE, LLC
DMSO 60 mg/ml by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Autophagy
Target LRRK2
Research Area Neurological Disease
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
GNE-9605 - Not Found
GNE-9605 - No Development Reported
7

Safety Data of GNE-9605

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AbMole BioScience 5mg/USD150(In stock) USA
Active Biochem 5mg/USD120() USA
AdooQ BioScience, LLC 5mg/USD96() USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD150();10mg/USD250() USA
Cayman Chemical Company USA
MedChemexpress Co., Ltd. 5mg/USD150();10mg/USD250() USA
MedKoo Biosciences, Inc. 5mg/USD150() USA
ProbeChem
Selleck Chemicals LLC 5mg/USD197(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD150();10mg/USD250() China
Target Molecule Corp. 2mg/USD87();5mg/USD119();25mg/USD298();100mg/USD637() USA
10

Related Products

Other Forms of 1536200-31-3

Name CAS No Formula MW

Recommended Compounds in LRRK2

Name CAS No Formula MW
CZC-25146 1191911-26-8 C22H25FN6O4S 488.54
CZC-25146 (hydrochloride) 1330003-04-7 C22H25FN6O4S 488.54
GNE0877 1374828-69-9 C14H16F3N7 339.32
GNE-7915 1351761-44-8 C19H21F4N5O3 443.4
HG-10-102-01 1351758-81-0 C17H20ClN5O3 377.83
GSK2578215A 1285515-21-0 C24H18FN3O2 399.417
LRRK2-IN-1 1234480-84-2 C31H38N8O3 570.69
JH-II-127 1700693-08-8 C19H21ClN6O3 416.86
CZC-54252 1191911-27-9 C22H25ClN6O4S 504.99
PF-06447475 1527473-33-1 C17H15N5O 305.33
MLi-2 1627091-47-7 C21H25N5O2 379.46
PFE-360 1527475-61-1 C16H16N6O 308.34
Lu AF58786 1632368-13-8 C19H16N6 328.37
GNE-7915 (tosylate) C26H29F4N5O6S 615.5969728
CZC-25146 (hydrochloride) 1330003-04-7 C22H26ClFN6O4S 524.996
GNE-09605 1536200-31-3 C17H20ClF4N7O 449.83

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

GNE-9605

Tags: buy 1536200-31-3 IC50 | 1536200-31-3 price | 1536200-31-3 cost | 1536200-31-3 solubility | 1536200-31-3 purchase | 1536200-31-3 manufacturer | 1536200-31-3 research buy | 1536200-31-3 order | 1536200-31-3 MSDS | 1536200-31-3 chemical structure | 1536200-31-3 Storage condition | 1536200-31-3 molecular weight | 1536200-31-3 mw | 1536200-31-3 datasheet | 1536200-31-3 supplier | 1536200-31-3 cell line | 1536200-31-3 NMR | 1536200-31-3 MS | 1536200-31-3 IR | 1536200-31-3 solubility | 1536200-31-3 Safe information | 1536200-31-3 Qc and Spectral Information | 1536200-31-3 Clinical Information | 1536200-31-3 Clinical Trial | 1536200-31-3 Route of Synthesis | 1536200-31-3 storage condition | 1536200-31-3 diseases and conditions | 1536200-31-3 flash point | 1536200-31-3 boiling point | 1536200-31-3 melting point | 1536200-31-3 storage condition | 1536200-31-3 brand