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235114-32-6 (Micafungin)

1

Identification

Micafungin Micafungin
Name Micafungin
Formula C56H71N9O23S
MW 1270.27
CAS No. 235114-32-6
EINECS
Smiles O=C([[email protected]](NC(C(NC([[email protected]@](C[[email protected]@H](O)C1)([H])N1C2=O)=O)[[email protected]](O)[[email protected]](C3=CC(OS(=O)(O)=O)=C(O)C=C3)O)=O)([H])[[email protected]](O)CC(N)=O)N4[[email protected]@](C(N[[email protected]@H]([[email protected]@H](C[[email protected]@H](C(NC2[[email protected]](O)C)=O)NC(C5=CC=C(C6=NOC(C7=CC=C(OCCCCC)C=C7)=C6)C=C5)=O)O)O)=O)([H])[[email protected]@H](O)[[email protected]@H](C)C4
Synonyms Mycamine;FK463;Funguard; 5-((1S,2S)-2-((2R,9S,11R,12R,14aS,15S,16S,20S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,11,12,15-tetrahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,8,14,19,22,25-hexaoxo-9-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzamido)tetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl)-1,2-dihydroxyethyl)-2-hydroxyphenyl hydrogen sulfate
InChI InChI=1S/C56H71N9O23S/c1-4-5-6-17-86-32-14-11-28(12-15-32)39-21-33(63-87-39)27-7-9-29(10-8-27)49(75)58-34-20-38(70)52(78)62-54(80)45-46(72)25(2)23-65(45)56(82)43(37(69)22-41(57)71)60-53(79)44(48(74)47(73)30-13-16-36(68)40(18-30)88-89(83,84)85)61-51(77)35-19-31(67)24-64(35)55(81)42(26(3)66)59-50(34)76/h7-16,18,21,25-26,31,34-35,37-38,42-48,52,66-70,72-74,78H,4-6,17,19-20,22-24H2,1-3H3,(H2,57,71)(H,58,75)(H,59,76)(H,60,79)(H,61,77)(H,62,80)(H,83,84,85)/t25-,26+,31+,34-,35-,37+,38+,42?,43-,44?,45-,46-,47-,48-,52+/m0/s1
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Introduction

Micafungin (Mycamine; FK463) is an echinocandin antifungal drug which can inhibit 1,3-beta-D-glucan synthase.

Background Information

In a mouse model of septic A. fumigatus infection, although non-treated mice survived for a maximum of only 6 days, the survival rate of micafungin-treated mice (0.1 mg kg-1) increased to 20%, while the survival rate of mice treated with a combination of ......by BOC Sciences
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000010084

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways Anti-infection
Target Fungal
Research Area Infection
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Micafungin - Launched
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Safety Data of Micafungin

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
Alfa Chemistry USA
BOC Sciences
CHEMSCENE, LLC 100mg/USD276();500mg/USD1140() USA
Carbosynth Limited 100mg/USD400()
MedChemexpress Co., Ltd. 100mg/USD276();500mg/USD1140() USA
Santa Cruz Biotechnology, Inc. 1mg/USD280() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD276();500mg/USD1140() China
Shanghai Techwell Biopharmaceutical Co., Ltd. China
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Related Products

Other Forms of 235114-32-6

Name CAS No Formula MW
Micafungin (sodium) 208538-73-2 C56H71N9NaO23S+ 1293.26

Recommended Compounds in Fungal

Name CAS No Formula MW
Pneumocandin B0 135575-42-7 C50H80N8O17 1065.21
UM729 1448723-60-1 C20H25N5O2 367.44
Sertaconazole (nitrate) 99592-39-9 C20H16Cl3N3O4S 500.78
Miconazole (nitrate) 22832-87-7 C18H15Cl4N3O4 479.14
Naftifine (hydrochloride) 65473-14-5 C21H22ClN 323.86
Hygromycin B 31282-04-9 C20H37N3O13 527.52
Miconazole 22916-47-8 C18H14Cl4N2O 416.13
Econazole (nitrate) 24169-02-6 C18H16Cl3N3O4 444.7
Ciclopirox 29342-05-0 C12H17NO2 207.27
Methasulfocarb 66952-49-6 C9H11NO4S2 261.32
Flumorph 211867-47-9 C21H22FNO4 371.4
Itraconazole 84625-61-6 C35H38Cl2N8O4 705.63
Tolnaftate 2398-96-1 C19H17NOS 307.41
Fenticonazole (Nitrate) 73151-29-8 C24H21Cl2N3O4S 518.41
Liranaftate 88678-31-3 C18H20N2O2S 328.43
Tioconazole 65899-73-2 C16H13Cl3N2OS 387.71
Bifonazole 60628-96-8 C22H18N2 310.39
Butoconazole (nitrate) 64872-77-1 C19H18Cl3N3O3S 474.79
Amphotericin B 1397-89-3 C47H73NO17 924.08
Amorolfine (hydrochloride) 78613-38-4 C21H36ClNO 353.97

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

[1]. Micafungin, From Wikipedia

Protocol Reference

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More Information

Micafungin

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