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873857-62-6 (Fidaxomicin)

1

Identification

Fidaxomicin Fidaxomicin
Name Fidaxomicin
Formula C52H74Cl2O18
MW 1058.04
CAS No. 873857-62-6
EINECS
Smiles O=C(C(C(O)=C(Cl)C(O)=C1Cl)=C1CC)O[[email protected]]([[email protected]](O[[email protected]]2OC/C(C(O[[email protected]](C/C=C3C)([H])[[email protected]](O)C)=O)=CC=CC[[email protected]@H](/C(C)=C[[email protected]](CC)[[email protected]@H](O[[email protected]@](OC(C)(C)[[email protected]@H](OC(C(C)C)=O)[[email protected]@H]4O)([H])[[email protected]]4O)C(C)=C/3)O)C)[[email protected]@H]([[email protected]@H]2OC)O
Synonyms OPT-80;PAR-101;Dificid;Dificlir;Clostomicin B1;Tiacumicin B; (2R,3S,4S,5S,6R)-6-(((3E,5E,8S,9Z,11S,12R,13Z,15Z,18S)-12-(((2R,3S,4R,5S)-3,4-dihydroxy-5-(isobutyryloxy)-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-11-ethyl-8-hydroxy-18-((R)-1-hydroxyethyl)-9,13,15-trimethyl-2-oxooxacyclooctadeca-3,5,9,13,15-pentaen-3-yl)methoxy)-4-hydroxy-5-methoxy-2-methyltetrahydro-2H-pyran-3-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate
InChI InChI=1S/C52H74Cl2O18/c1-13-30-22-26(6)33(56)18-16-15-17-31(23-66-51-45(65-12)42(61)44(29(9)67-51)69-49(64)35-32(14-2)36(53)39(58)37(54)38(35)57)48(63)68-34(28(8)55)20-19-25(5)21-27(7)43(30)70-50-41(60)40(59)46(52(10,11)72-50)71-47(62)24(3)4/h15-17,19,21-22,24,28-30,33-34,40-46,50-51,55-61H,13-14,18,20,23H2,1-12H3/b16-15+,25-19-,26-22-,27-21-,31-17+/t28-,29-,30+,33+,34+,40-,41+,42+,43+,44-,45+,46+,50-,51-/m1/s1
2

Introduction

Fidaxomicin(OPT-80; PAR-101) is a new class of narrow spectrum macrocyclic antibiotic drug; selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora.

Background Information

A natural macrocyclic antibiotic that inhibits RNA polymerase with selectivity for Gram-positive bacteria over Gram-negative bacteria ......by AOBIOUS INC
Fidaxomicin is the major analogue of a family of macrocyclic lactones isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3, tiacumicin B and clostomicin B1, respectively. Fidaxomicin is a narrow spectrum antibiotic with excellent activity against Gram positive bacteria, notably Clostridium difficile. Fidaxomicin acts in the gastrointestinal tract without undue disruption to gut microbial flora. ......by AdooQ BioScience, LLC
Fidaxomicin(OPT-80; PAR-101) is a new class of narrow spectrum macrocyclic antibiotic drug; selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal f ......by BOC Sciences
Fidaxomycin is a natural macrocyclic antibiotic and RNA polymerase inhibitor that displays selectivity for Gram-positive bacteria over Gram-negative bacteria (IC₅₀s = 0.4 and 6 μM, respectively). It shows potent antibacterial activity against most Gram-positive bacteria and effectively targets the Gram-positive C. difficile (MIC = 12 ng/ml). Also shown to have excellent bactericidal activity against multidrug-resistant Mycobacterium tuberculosis. ......by BioVision, Inc.,
Fidaxomicin is the first in a new class of narrow spectrum macrocyclic antibiotic drugs. It is a fermentation product obtained from the actinomycete Dactylosporangium aurantiacum subspecies hamdenesis. Fidaxomicin is non-systemic, meaning it is minimally absorbed into the bloodstream, it is bactericidal, and it has demonstrated selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora. The maintenance of normal physiological conditions in the colon can reduce the probability of Clostridium difficile infection recurrence. (Source: http://en.wikipedia.org/wiki/Fidaxomicin). ......by MedKoo Biosciences, Inc.
Fidaxomicin(OPT-80; PAR-101) is a new class of narrow spectrum macrocyclic antibiotic drug, selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria.Bacterial InfectionApproved ......by ProbeChem
Fidaxomicin is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit. ......by Selleck Chemicals LLC
Fidaxomicin is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000010083

Storage condition

Solubility

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Mechanism and Indication

Signaling Pathways Anti-infection
Target Bacterial
Research Area Infection
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Fidaxomicin - Launched
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Safety Data of Fidaxomicin

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AOBIOUS INC USA
AdooQ BioScience, LLC USA
Ark Pharm, Inc. USA
BOC Sciences 50mg/USD298(In stock);2g/USD490(In stock)
BioVision, Inc., 5mg/USD575() USA
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD50();10mg/USD65() USA
Carbosynth Limited 1mg/USD420()
Cayman Chemical Company 10mg/USD45() USA
Clearsynth Labs Limited 25mg/USD1000() India
Eastbang Pharmaceuticals Science & Technology Co., Ltd CHINA
Lancrix Chemicals. 100mg/USD135();250mg/USD305() China
MedChemexpress Co., Ltd. 5mg/USD50();10mg/USD65() USA
MedKoo Biosciences, Inc. USA
ProbeChem
Pure Chemistry Scientific Inc. 10mg/USD156(In stock) USA
Santa Cruz Biotechnology, Inc. USA
Selleck Chemicals LLC 50mg/USD122(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD50();10mg/USD65() China
Target Molecule Corp. 2mg/USD32();10mg/USD68();50mg/USD135();100mg/USD225() USA
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Related Products

Other Forms of 873857-62-6

Name CAS No Formula MW

Recommended Compounds in Bacterial

Name CAS No Formula MW
AVX 13616 900814-48-4 C50H73Cl2N7O7 955.06
Bedaquiline (fumarate) 845533-86-0 C36H35BrN2O6 671.58
Mafenide (Acetate) 13009-99-9 C9H14N2O4S 246.28
Cefozopran 113359-04-9 C19H17N9O5S2 515.53
Azithromycin 83905-01-5 C38H72N2O12 748.9845
Pazufloxacin 127045-41-4 C16H15FN2O4 318.3
Pazufloxacin (mesylate) 163680-77-1 C17H19FN2O7S 414.4054
Capreomycin (sulfate) 1405-37-4 C24H44N14O12S 752.76
Bleomycin (sulfate) 9041-93-4 C110H168N34O46S7 2927.17
G-418 (disulfate) 108321-42-2 C20H44N4O18S2 692.71
Demeclocycline (hydrochloride) 64-73-3 C21H22Cl2N2O8 501.31
Apramycin 37321-09-8 C21H41N5O11 539.58
Ceftriaxone 73384-59-5 C18H18N8O7S3 554.58
Ceftibuten 97519-39-6 C15H14N4O6S2 410.42
Dapsone 80-08-0 C12H12N2O2S 248.3
Vancomycin 1404-90-6 C66H76Cl3N9O24 1485.72
Lomefloxacin 98079-51-7 C17H19F2N3O3 351.35
Dirithromycin 62013-04-1 C42H78N2O14 835.07
Cefepime (Dihydrochloride Monohydrate) 123171-59-5 C19H28Cl2N6O6S2 571.5
Mafenide 138-39-6 C7H10N2O2S 186.23

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Fidaxomicin

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