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1306760-87-1 (Ozanimod)

1

Identification

Ozanimod Ozanimod
Name Ozanimod
Formula C23H24N4O3
MW 404.4617
CAS No. 1306760-87-1
EINECS
Smiles N#CC1=CC(C2=NC(C3=CC=CC4=C3CC[[email protected]@H]4NCCO)=NO2)=CC=C1OC(C)C
Synonyms RPC-1063
InChI InChI=1S/C23H24N4O3/c1-14(2)29-21-9-6-15(12-16(21)13-24)23-26-22(27-30-23)19-5-3-4-18-17(19)7-8-20(18)25-10-11-28/h3-6,9,12,14,20,25,28H,7-8,10-11H2,1-2H3/t20-/m0/s1
2

Introduction

Ozanimod is a potent and selective S1P1 and S1P5 receptor agonist with EC50s of 410±160 pM and 11±4.3 nM in [35S]-GTPγS binding, respectively.

Background Information

RPC1063 is a selective sphingosine 1 phosphate receptor modulators and methods which may be useful in the treatment of S1P1-?associated diseases. ......by AdooQ BioScience, LLC
Ozanimod (RPC1063) is a selective oral S1P Receptor 1 modulator. Phase 3. ......by BOC Sciences
Ozanimod (RPC1063) is an orally bioavailable agonist of the sphingosine-1-phosphate receptor subtypes 1 (S1P1) and 5 (S1P5). S1P receptors belong to the family of G-protein-coupled receptor which contains five subtypes, denoting S1P1-5. S1P receptors are involved in coronary artery caliber, endothelial integrity, cardiac function, and lymphocyte recirculation. ......by BioVision, Inc.,
Ozanimod is a potent and selective S1P1 and S1P5 receptor agonist with EC50s of 410±160 pM and 11±4.3 nM in [35S]-GTPγS binding, respectively. ......by MedChemexpress Co., Ltd.
Ozanimod, also known as RPC1063, is a selective sphingosine 1 phosphate receptor modulators and methods which may be useful in the treatment of S1P1-​associated diseases. ......by MedKoo Biosciences, Inc.
Ozanimod (RPC-1063) is a potent, selective agonist of S1P1 and S1P5 receptor with EC50 of 0.41 nM and 11 nM respectively; less potent for S1P2, S1P3 and S1P4 (EC50> 10 uM); induces S1P1 receptor internalization and induced a reversible reduction in circulating B and CCR7(+) T lymphocytes in vivo; shows high oral bioavailability and volume of distribution, and a circulatory half-life.Multiple SclerosisPhase 3 Clinical ......by ProbeChem
Ozanimod (RPC1063) is a selective oral S1P Receptor 1 modulator. Phase 3. ......by Selleck Chemicals LLC
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000010038

Storage condition

Store in a tightly closed container, in a cool and dry place. by MedChemexpress Co., Ltd.

Solubility

DMSO: 30 mg/mL by CHEMSCENE, LLC
DMSO: 30 mg/mL by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways GPCR/G Protein
Target LPL Receptor
Research Area Inflammation/Immunology
Indications Ulcerative Colitis
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Ozanimod Receptos, Inc. Ulcerative Colitis 2015/4/24 2015/9/1 Phase 3 Clinical
Ozanimod - No Development Reported
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Safety Data of Ozanimod

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
A2Z Chemical 1g/USD4180(in stock);5g/USD12530(inquire);10g/USD20880(inquire) USA
AdooQ BioScience, LLC USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
BioVision, Inc., USA
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD144();10mg/USD228() USA
Cayman Chemical Company USA
DC Chemicals 100mg/USD1200(In stock) China
MedChemexpress Co., Ltd. 5mg/USD144();10mg/USD228() USA
MedKoo Biosciences, Inc. USA
ProbeChem
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD144();10mg/USD228() China
10

Related Products

Other Forms of 1306760-87-1

Name CAS No Formula MW
Ozanimod (hydrochloride) 1306760-85-9 C23H25ClN4O3 440.9226

Recommended Compounds in LPL Receptor

Name CAS No Formula MW
Ozanimod (hydrochloride) 1306760-85-9 C23H25ClN4O3 440.9226
LPA2 antagonist 1 1017606-66-4 C20H23Cl2N5O2S2 500.46
AM095 (free acid) 1228690-36-5 C27H24N2O5 456.4899
AM095 1345614-59-6 C27H23N2NaO5 478.47
AM966 1228690-19-4 C27H23ClN2O5 490.93
4-Thiazolidinone, 5-[[3-chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]methylene]-3-(2-methylphenyl)-2-(propylimino)-, (2Z,5Z)- 854107-55-4 C22H23ClN2O4S 446.95
Ki16425 355025-24-0 C23H23ClN2O5S 474.96
TY-52156 934369-14-9 C18H19Cl2N3O 364.269
Cenerimod 1262414-04-9 C25H31N3O5 453.53
S1P1 Agonist III 1324003-64-6 C21H16F3N3O3 415.37
Etrasimod 1206123-37-6 C26H26F3NO3 457.4847
Siponimod 1230487-00-9 C29H35F3N2O3 516.6
ML249 945128-26-7 C13H9Br2Cl2NO2 441.93
Amiselimod (hydrochloride) 942398-84-7 C19H31ClF3NO3 413.9
BMS-986020 1257213-50-5 C29H26N2O5 482.53
S1p receptor agonist 1 1514888-56-2 C23H24FN3O3 0.0
ONO-7300243 638132-34-0 C28H31NO5 461.55
AKP-11 1220973-37-4 C22H22ClN3O5 443.88
ONO-0300302 856689-51-5 C29H35NO5 477.59
Ponesimod 854107-55-4 C23H25ClN2O4S 460.9736

Recommended Compounds in Same Indication

Name CAS No Formula MW
Ozanimod (hydrochloride) 1306760-85-9 C23H25ClN4O3 440.9226
LX1606 (Hippurate) 1137608-69-5 C36H35ClF3N7O6 754.15
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Route of Synthesis

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References

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More Information

Ozanimod

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