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1315329-43-1 (HG6-64-1)

1

Identification

HG6-64-1 HG6-64-1
Name HG6-64-1
Formula C32H34F3N5O2
MW 577.64
CAS No. 1315329-43-1
EINECS
Smiles O=C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(/C=C/C4=CN=C(NC=C5)C5=C4OC)=C3
Synonyms HG-6-64-1;HG 6-64-1; (E)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)vinyl)-4-methylbenzamide
InChI InChI=1S/C32H34F3N5O2/c1-4-39-13-15-40(16-14-39)20-25-9-10-26(18-28(25)32(33,34)35)38-31(41)23-6-5-21(2)22(17-23)7-8-24-19-37-30-27(11-12-36-30)29(24)42-3/h5-12,17-19H,4,13-16,20H2,1-3H3,(H,36,37)(H,38,41)/b8-7+
2

Introduction

HG6-64-1 is a potent and selective B-Raf inhibitor extracted from patent WO 2011090738 A2, example 9 (XI-1); has a IC50 of 0.09 μM on B-raf V600E transformed Ba/F3 cells.

Background Information

HG6-64-1 is a potent and selective B-Raf and mutant B-Raf inhibitor; more information can be found in Patent WO 2011090738. ......by AdooQ BioScience, LLC
HG6-64-1 is a potent and selective B-Raf and mutant B-Raf inhibitor; more information can be found in Patent WO 2011090738. ......by BOC Sciences
HG6-64-1 is a potent and selective B-Raf inhibitor extracted from patent WO 2011090738 A2, example 9 (XI-1); has a IC50 of 0.09 μM on B-raf V600E transformed Ba/F3 cells. ......by MedChemexpress Co., Ltd.
HG-6-64-1 is a selective B-Raf and mutant B-Raf inhibitor. ......by MedKoo Biosciences, Inc.
HG6-64-1 is a potent dual TAK1 and MAP4K2 ((germinal center kinase, GCK)) inhibitor with IC50 of 41 nM and 98 nM, respectively; also inhibits ZAK, p38α, Src, Lyn, CSK and EPH-family kinases (IC50=50-100 nM); inhibits GCK signaling DLBCL cell lines with EC50 of 1.83-157 nM, induces G0/G1 cell-cycle arrest and cell death; inhibits the growth of DLBCL xenograft tumors and prolongs the survival of tumor-bearing mice. ......by ProbeChem
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000010031

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

10 mM in DMSO by CHEMSCENE, LLC
10 mM in DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways MAPK/ERK Pathway
Target Raf
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
HG6-64-1 - Not Found
HG6-64-1 - No Development Reported
7

Safety Data of HG6-64-1

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD420();10mg/USD600() USA
MedChemexpress Co., Ltd. 5mg/USD420();10mg/USD600() USA
MedKoo Biosciences, Inc. USA
ProbeChem
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD420();10mg/USD600() China
10

Related Products

Other Forms of 1315329-43-1

Name CAS No Formula MW

Recommended Compounds in Raf

Name CAS No Formula MW
B-Raf inhibitor 1 (dihydrochloride) 1191385-19-9 C26H21Cl3N8 551.86
TAK-632 1228591-30-7 C27H18F4N4O3S 554.52
Dabrafenib (Mesylate) 1195768-06-9 C24H24F3N5O5S3 615.67
LGX818 1269440-17-6 C22H27ClFN7O4S 540.01
B-Raf IN 1 950736-05-7 C29H24F3N5O 515.53
B-Raf inhibitor 1315330-11-0 C29H31F3N6O2 552.59
MLN 2480 1096708-71-2 C17H12Cl2F3N7O2S 506.29
CEP-32496 1188910-76-0 C24H22F3N5O5 517.46
CEP-32496 (hydrochloride) 1227678-26-3 C24H23ClF3N5O5 553.92
Dabrafenib 1195765-45-7 C23H20F3N5O2S2 519.56
B-Raf inhibitor 1 1093100-40-3 C26H19ClN8 478.94
ZM 336372 208260-29-1 C23H23N3O3 389.45
Sorafenib 284461-73-0 C21H16ClF3N4O3 464.83
RAF265 927880-90-8 C24H16F6N6O 518.41
Doramapimod 285983-48-4 C31H37N5O3 527.66
Vemurafenib 918504-65-1 C23H18ClF2N3O3S 489.92
Sorafenib (Tosylate) 475207-59-1 C28H24ClF3N4O6S 637.03
GDC-0879 905281-76-7 C19H18N4O2 334.37
PLX-4720 918505-84-7 C17H14ClF2N3O3S 413.83
SB-590885 405554-55-4 C27H27N5O2 453.54

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

HG6-64-1

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