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459836-30-7 (PEAQX)

1

Identification

PEAQX PEAQX
Name PEAQX
Formula C17H17BrN3O5P
MW 454.2117
CAS No. 459836-30-7
EINECS
Smiles O=C1C(NC2=C(C(C(P(O)(O)=O)N[[email protected]](C3=CC=C(Br)C=C3)C)=CC=C2)N1)=O
Synonyms NVP-AAM077
InChI InChI=1S/C17H17BrN3O5P/c1-9(10-5-7-11(18)8-6-10)19-17(27(24,25)26)12-3-2-4-13-14(12)21-16(23)15(22)20-13/h2-9,17,19H,1H3,(H,20,22)(H,21,23)(H2,24,25,26)/t9-,17?/m0/s1
2

Introduction

NVP-AAM077 inhibited progenitor cells proliferation in the subventricular zone and dentate gyrus and reduced the survival of newborn cells in the dentate gyrus in the adult mice.

Background Information

NMDA receptor antagonist ......by AOBIOUS INC
NVP-AAM077 inhibited progenitor cells proliferation in the subventricular zone and dentate gyrus and reduced the survival of newborn cells in the dentate gyrus in the adult mice. ......by AdooQ BioScience, LLC
PEAQX(NVP-AAM 077) is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A(IC50=270 nM), rather than 1A/2B(29,600 nM). ......by BOC Sciences
PEAQX, also known as NVP-AAM077; is a competitive antagonist at the NMDA receptor. Although originally described as 100-fold selective for GluN1/GluN2A receptors vs. GluN1/GluN2B receptors, more detailed studies of the Ki of PEAQX revealed it only shows a 5 fold difference in affinity for GluN1/GluN2A vs. GluN1/GluN2B receptors. It is also a potent anticonvulsant in animal tests. ......by MedKoo Biosciences, Inc.
PEAQX (NVP-AAM077) is a potent, selective, NR2A-preferring NMDA receptor antagonist with IC50 of 270 nM (NR1A/2A), >100-fold selectivity over NR1A/2B receptor (IC50=29,600 nM); shows high binding affinity for NMDA receptors (IC50=8 nM), induces social facilitation in adolescent male rats (1.25, 3.75mg/kg); enhances locomotor activity in response to PCP challenge in vivo. ......by ProbeChem
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB000010005

Storage condition

Solubility

10 mM in DMSO by CHEMSCENE, LLC
10 mM in DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways Membrane Transporter/Ion Channel Neuronal Signaling
Target iGluR
Research Area Neurological Disease
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
PEAQX - No Development Reported
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Safety Data of PEAQX

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AOBIOUS INC USA
AdooQ BioScience, LLC USA
Apexbio Technology LLC 5mg/USD114(Ship Within 10-14 Days) USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD144();10mg/USD240() USA
MedChemexpress Co., Ltd. 5mg/USD144();10mg/USD240() USA
MedKoo Biosciences, Inc. USA
ProbeChem
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD144();10mg/USD240() China
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Related Products

Other Forms of 459836-30-7

Name CAS No Formula MW

Recommended Compounds in iGluR

Name CAS No Formula MW
Dextromethorphan (hydrobromide) 125-69-9 C18H26BrNO 352.31
Piracetam 7491-74-9 C6H10N2O2 142.16
Meclofenoxate (hydrochloride) 3685-84-5 C12H17Cl2NO3 294.17
Coluracetam 135463-81-9 C19H23N3O3 341.4
NMDA 6384-92-5 C5H9NO4 147.13
Sunifiram 314728-85-3 C14H18N2O2 246.3
SDZ 220-581 (hydrochloride) 179411-93-9 C16H18Cl2NO5P 406.2
Orphenadrine (citrate) 4682-36-4 C24H31NO8 461.5
Memantine (hydrochloride) 41100-52-1 C12H22ClN 215.76
Ro 25-6981 (Maleate) 1312991-76-6 C26H33NO6 455.54
Ro 25-6981 169274-78-6 C22H29NO2 339.47
Felbamate (hydrate) 1177501-39-1 C11H16N2O5 256.26
Felbamate 25451-15-4 C11H14N2O4 238.24
Flupirtine 56995-20-1 C15H17FN4O2 304.32
Noopept 157115-85-0 C17H22N2O4 318.37
QNZ46 1237744-13-6 C24H17N3O6 443.4083
SDZ 220-581 (Ammonium salt) 179411-94-0 C16H20ClN2O5P 386.77
MDL-29951 130798-51-5 C12H9Cl2NO4 302.11
MDL 105519 161230-88-2 C18H11Cl2NO4 376.19
(-)-MK 801 (Maleate) 121917-57-5 C20H19NO4 337.3692

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

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More Information

PEAQX

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