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865231-45-4 (AMG 837 (sodium salt))

1

Identification

AMG 837 (sodium salt) AMG 837 (sodium salt)
Name AMG 837 (sodium salt)
Formula C26H20F3NaO3
MW 460.42
CAS No. 865231-45-4
EINECS
Smiles O=C(O[Na])C[[email protected]](C#CC)C1=CC=C(C=C1)OCC2=CC=CC(C3=CC=C(C(F)(F)F)C=C3)=C2
Synonyms AMG-837 sodium salt;AMG837 sodium salt; sodium (S)-3-(4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)hex-4-ynoate
InChI InChI=1S/C26H21F3O3.Na/c1-2-4-21(16-25(30)31)20-9-13-24(14-10-20)32-17-18-5-3-6-22(15-18)19-7-11-23(12-8-19)26(27,28)29;/h3,5-15,21H,16-17H2,1H3,(H,30,31);/q;+1/p-1/t21-;/m0./s1
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Introduction

AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. IC50 value: 13 nM (EC50) [1] Target: GPR40 agonist AMG 837 displayed the expected two-fold increase in potency on GPR4 (EC50 = 13 [±7] nM) compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40 (EC50 = 23 and 13 nM, respectively).

Background Information

AMG 837 sodium salt is a potent GPR40 agonist with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. It displayed the expected two-fold increase in potency on GPR4 compared to the racemic compound ......by BOC Sciences
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000010004

Storage condition

Solubility

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Mechanism and Indication

Signaling Pathways GPCR/G Protein
Target GPR40
Research Area Metabolic Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
AMG 837 (sodium salt) - Not Found
AMG 837 (sodium salt) - No Development Reported
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Safety Data of AMG 837 (sodium salt)

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC USA
Ark Pharm, Inc. USA
BOC Sciences
CHEMSCENE, LLC 5mg/USD156();10mg/USD228() USA
MedChemexpress Co., Ltd. 5mg/USD156();10mg/USD228() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD156();10mg/USD228() China
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Related Products

Other Forms of 865231-45-4

Name CAS No Formula MW
AMG 837 (calcium hydrate) 1259389-38-2 C26H22F3O4- 455.45
AMG 837 865231-46-5 C26H21F3O3 438.44

Recommended Compounds in GPR40

Name CAS No Formula MW
AMG 837 (calcium hydrate) 1259389-38-2 C26H22F3O4- 455.45
GPR40 Activator 1 1309435-60-6 C31H31NO3S 497.65
AMG 837 865231-46-5 C26H21F3O3 438.44
TUG-770 1402601-82-4 C19H14FNO2 307.32
GW9508 885101-89-3 C22H21NO3 347.41
TAK-875 1000413-72-8 C29H32O7S 524.63
GW-1100 306974-70-9 C27H25FN4O4S 520.58
GPR40 Activator 2 1312787-30-6 C28H29NO6S2 539.66
DC260126 346692-04-4 C32H31N5O 501.62
M-I C19H22O5S 362.44
T-1676427 1000414-39-0 C29H32O8S 540.62
JTT-851 C23H28O3 352.47
Astellas C27H30N4O4 474.55
MK-2305 905723-46-8 C19H13ClF3NO4S 443.82
Mochida 1469495-84-8 C30H35NO6S 537.67
BMS-986118 1610562-74-7 C25H28ClF3N4O4 540.96
AM-6226 C32H36F2O4 522.62
GPR40 agonist 1 1312788-44-5 C24H20O3 356.41
GPR40 agonist 2 C25H22O3 370.44
GPR40 agonist 3 C23H18O3 342.39

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

AMG 837 (sodium salt)

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