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ProbeChem

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Company Name:ProbeChem

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Introduction of ProbeChem

Web: www.probechem.com TEL:86-21-80183644 Fax:86-21-68860190 Email:[email protected]

Products of ProbeChem

  • Chemical Name: PEAQX
    CAS No.: 459836-30-7 Purity: Appearances:
    Brand: Synonyms: NVP-AAM077 Quality Control & MSDS Files:
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    Brief introduction:

    PEAQX (NVP-AAM077) is a potent, selective, NR2A-preferring NMDA receptor antagonist with IC50 of 270 nM (NR1A/2A), >100-fold selectivity over NR1A/2B receptor (IC50=29,600 nM); shows high binding affinity for NMDA receptors (IC50=8 nM), induces social facilitation in adolescent male rats (1.25, 3.75mg/kg); enhances locomotor activity i...

  • Chemical Name: LY2857785
    CAS No.: 1619903-54-6 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: LY 2857785;LY-2857785; (1r,... Quality Control & MSDS Files:
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    Brief introduction:

    LY2857785 is a potenrt, reversible and ATP-competitive CDK9 inhibitor with IC50 of 11 nM, also inhibits CDK8 (IC50=16 nM) and weakly inhibits CSK7 (IC50=246 nM); showes good selectivity against a panel of 114 protein kinases; inhibits RNAP II C-terminal domain (CTD) P-Ser2 and CTD P-Ser5 in U2OS cells with IC50 of 89 and 42 nM, dramati...

  • Chemical Name: IM-12
    CAS No.: 1129669-05-1 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: IM 12;IM12; 3-((4-fluorophe... Quality Control & MSDS Files:
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    Brief introduction:

    IM-12 is a novel potent GSK-3β inhibitor with IC50 of 53 nM, significantly increases the β-catenin level and activates canonical Wnt signalling; attenuates cell proliferation of ReNcell VM cells, induces nuclear accumulation of beta-catenin.

  • Chemical Name:
    CAS No.: 1403783-31-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 4-((1-butyl-3-phenylureido)... Quality Control & MSDS Files:
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    Brief introduction:

    A potent and selective HDAC6 inhibitor with IC50 of 5 nM; displays >100-fold selectivity over other HDAC isozymes (600-fold relative to the inhibition of HDAC1).

  • Chemical Name: MMAD hydrochloride
    CAS No.: 173441-26-4 Purity: Appearances: White to off-white solid
    Brand: Synonyms: Demethyldolastatin 10 hydro... Quality Control & MSDS Files:
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    Brief introduction:

    A potent tubulin inhibitor that is a toxin payload in antibody drug conjugates (ADCs).

  • Chemical Name: HG6-64-1
    CAS No.: 1315329-43-1 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: HG-6-64-1;HG 6-64-1; (E)-N-... Quality Control & MSDS Files:
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    Brief introduction:

    HG6-64-1 is a potent dual TAK1 and MAP4K2 ((germinal center kinase, GCK)) inhibitor with IC50 of 41 nM and 98 nM, respectively; also inhibits ZAK, p38α, Src, Lyn, CSK and EPH-family kinases (IC50=50-100 nM); inhibits GCK signaling DLBCL cell lines with EC50 of 1.83-157 nM, induces G0/G1 cell-cycle arrest and cell death; inhibits the gr...

  • Chemical Name: RGDS peptide
    CAS No.: 91037-65-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: RGDS peptide;Fibronectin In... Quality Control & MSDS Files:
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    Brief introduction:

    RGDS peptide (Arg-Gly-Asp-Ser) is a integrin binding sequence that inhibits integrin receptor function, a tetrapeptide analogue of the cell attachment site of fibronectin; decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9; in...

  • Chemical Name: Defactinib
    CAS No.: 1073154-85-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: VS-6063;VS6063;VS 6063; N-m... Quality Control & MSDS Files:
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    Brief introduction:

    Defactinib (VS-6063, PF-04554878) is a potent, selective and orally active FAK inhibitor, selectively inhibits pFAK (Tyr397) in a dose-dependent manner in cancer cell lines; shows no statistically significant changes in FAK phosphorylation at the other residues(Tyr 576/577, Tyr 925, or Tyr 861), also inhibits Pyk2 Tyr402 phosphorylatio...

  • Chemical Name: Ozanimod
    CAS No.: 1306760-87-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: RPC-1063 Quality Control & MSDS Files:
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    Brief introduction:

    Ozanimod (RPC-1063) is a potent, selective agonist of S1P1 and S1P5 receptor with EC50 of 0.41 nM and 11 nM respectively; less potent for S1P2, S1P3 and S1P4 (EC50> 10 uM); induces S1P1 receptor internalization and induced a reversible reduction in circulating B and CCR7(+) T lymphocytes in vivo; shows high oral bioavailability and vol...

  • Chemical Name: YH239-EE
    CAS No.: 1364488-67-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: YH 239-EE;YH 239 EE; ethyl ... Quality Control & MSDS Files:
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    Brief introduction:

    YH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM, shows no affinity for MDM4; induces apoptosis in AML cells and patient samples, induces p53 and activates the apoptotic caspase 3/7 in MOLM-13 (wt-p53) cells.

  • Chemical Name: PI-1840
    CAS No.: 1401223-22-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: PI 1840;PI1840; N-isopropyl... Quality Control & MSDS Files:
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    Brief introduction:

    PI-1840 is a potent, selective, noncovalent, reversible inhibitor for proteasome chymotrypsin-like (CT-L) activity with IC50 of 27 nM, shows no effect on trypsin-like and peptidylglutamyl peptide hydrolyzing activities (IC50>100 uM); also displays 100-fold more selectivity for the constitutive proteasome over the immunoproteasome; indu...

  • Chemical Name:
    CAS No.: 88426-33-9 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: Butalex; 2-((4-(tert-butyl)... Quality Control & MSDS Files:
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    Brief introduction:

    A hydroxynaphthoquinone antiprotozoal drug related to parvaquone and atovaquone.

  • Chemical Name: MLN1117
    CAS No.: 1268454-23-4 Purity: Appearances: White to gray Solid
    Brand: Synonyms: Serabelisib;INK1117 Quality Control & MSDS Files:
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    Brief introduction:

    MLN1117 (INK1117,TAK-117, Serabelisib) is a potent, selective PI3K p110α inhibitor with IC50 of 15 nM, displays >300-fold selectivity over p110β/γ/δ and mTOR; inhibits AKT phosphorylation and growth in PIK3CA mutant breast cancer cells with IC50 of 2 uM, significantly suppresses B cell proliferation driven by anti-IgM alone but not by ...

  • Chemical Name: Rostafuroxin
    CAS No.: 156722-18-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: PST-2238;PST 2238;PST2238; ... Quality Control & MSDS Files:
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    Brief introduction:

    Rostafuroxin (PST2238) is potent, selective, orally active Na-K-ATPase inhibitor, displaces 3H ouabain from dog kidney Na+,K+-ATPase with IC50 of 1.5 nM; displays excellent selectivity over a panel of general and hormonal receptors, with exception of thromboxane A2 receptor (61% inhibition at 1 uM); abolishes ouabain-dependent increase...

  • Chemical Name: Saxagliptin hydrate
    CAS No.: 945667-22-1 Purity: Appearances:
    Brand: Synonyms: BMS-477118 hydrate;Onglyza ... Quality Control & MSDS Files:
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    Brief introduction:

    A highly potent, long-acting, orally active DPP4 inhibitor with Ki of 0.6 nM; shows no CYP3A4 inhibition up to 100 uM, and good oral exposure.DiabetesApproved

  • Chemical Name: Fidaxomicin
    CAS No.: 873857-62-6 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: OPT-80;PAR-101;Dificid;Difi... Quality Control & MSDS Files:
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    Brief introduction:

    Fidaxomicin(OPT-80; PAR-101) is a new class of narrow spectrum macrocyclic antibiotic drug, selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria.Bacterial InfectionApproved

  • Chemical Name: Micafungin
    CAS No.: 235114-32-6 Purity: Appearances:
    Brand: Synonyms: Mycamine;FK463;Funguard; 5-... Quality Control & MSDS Files:
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    An echinocandin antifungal drug which can inhibit 1,3-beta-D-glucan synthase. Fungal InfectionApproved

  • Chemical Name: GNE-9605
    CAS No.: 1536200-31-3 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: GNE 9605;GNE9605;N2-(5-chlo... Quality Control & MSDS Files:
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    Brief introduction:

    GNE-9605 is a highly potent, selective, brain penetrant LRRK2 inhibitor with Ki of 2 nM, pLRRK2 IC50 of 19 nM; dispalys excellent selectivity against 178-membered Invitrogen kinase panel, as well as a representative panel of receptors and ion channels; demonstrates robust concentration-dependent inhibition of LRRK2 Ser1292 autophosphor...

  • Chemical Name: FPH2
    CAS No.: 957485-64-2 Purity: Appearances:
    Brand: Synonyms: FPH 2;FPH-2;BRD-9424;BRD 94... Quality Control & MSDS Files:
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    Brief introduction:

    A small molecule that promotes differentiation of iPS-derived hepatocytes; induces functional proliferation of hepatocytes in vitro, and thus expands mature human primary hepatocytes. FPH2 may lead to the development of new therapeutics for liver diseases.

  • Chemical Name: THZ2
    CAS No.: 1604810-84-5 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: THZ2; THZ 2; THZ-2. Quality Control & MSDS Files:
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    Brief introduction:

    THZ2, an analogue of THZ1 with improved pharmacokinetic features, is a potent, selective CDK7 inhibitor with IC50 of 13.9 nM, displays a 5-fold improved half-life in vivo compared with THZ1; selectively targets CDK7 and potently inhibits the growth of triple-negative but not ER/PR+ breast cancer cells, efficiently suppresses the clonog...