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Tocris Bioscience Inc.

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Basic Information

Company Name:Tocris Bioscience Inc.

Business Type:Chemical manufacturer since 1982

Total NO.Employees:50

Country/Region:USA

Certificates:

Year Established: 1982

Introduction of Tocris Bioscience Inc.

Tocris Bioscience is the trading name of Tocris Cookson Ltd., which is headquartered in Bristol, UK. There are approximately 50 employees in the company. In May 2011 Tocris Bioscience was wholly acquired by R&D Systems, headquartered in Minneapolis, MN, USA.

Web: www.tocris.com TEL:+1 (636) 207-7651 Fax:+1 (636) 207-7683 Email:[email protected]; [email protected]

Products of Tocris Bioscience Inc.

  • Chemical Name: CPI-203
    CAS No.: 1446144-04-2 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: CPI203;CPI 203; 2-((6S)-4-(... Quality Control & MSDS Files:
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    CPI 203 is a novel potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 with an IC50 of ~37 nM (BRD4 α-screen assay). IC50 value:37 nM [1] Target: BRD4 in vitro: Like JQ1, CPI203 inhibits BRD4 in vitro and in cells .

  • Chemical Name: APY29
    CAS No.: 1216665-49-4 Purity: Appearances: light yellow to khaki Solid
    Brand: Synonyms: APY 29;APY-29; N2-(1H-benzo... Quality Control & MSDS Files:
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    APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity. IC50 value: 280 nM [1] Target: IRE1α APY29 is a highly potent and selective small molecule modulator of IRE1α.

  • Chemical Name: STF-083010
    CAS No.: 307543-71-1 Purity: Appearances: Light yellow to yellow Solid
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    STF-083010 is an <b>Ire1</b> inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress.

  • Chemical Name: AG 825
    CAS No.: 149092-50-2 Purity: Appearances:
    Brand:Tocris Synonyms: Tyrphostin AG 825; (E)-3-(3... Quality Control & MSDS Files:
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    Selective ErbB2 inhibitor (IC<sub>50</sub> values are 0.15 and 19 <span class='symbol'>&#956;</span>M at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.

  • Chemical Name: SF 1670
    CAS No.: 345630-40-2 Purity: #98 % Appearances:
    Brand:Tocris Synonyms: SF 1670;SF-1670; N-(9,10-di... Quality Control & MSDS Files:
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    PTEN inhibitor. Increases fMLP-elicited PIP<sub>3</sub> signaling, Akt -phosphorylation and production of reactive oxygen species in neutrophils <em>in vitro</em>. Pretreatment of transfused neutrophils enhances chemotaxis to sites of bacterial infection and increases survival in neutropenic mice.

  • Chemical Name: Oxymetazoline hydrochloride
    CAS No.: 2315-02-8 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: 2-(3-Hydroxy-2,6-dimethyl-4... Quality Control & MSDS Files:
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    Partial <span class='symbol'>&alpha;</span><sub>2A</sub> adrenoceptor agonist and <span class='symbol'>&alpha;</span><sub>1A</sub> agonist. Agonist/antagonist activity at 5-HT receptors.

  • Chemical Name: Olopatadine hydrochloride
    CAS No.: 140462-76-6 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: (Z)-11-[3-(Dimethylamino)pr... Quality Control & MSDS Files:
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    Histamine H<sub>1</sub> receptor antagonist (K<sub>i</sub> = 31.6 nM). Inhibits the release of histamine, prostaglandin D<sub>2</sub> and tryptase in a concentration-dependent manner. Mast cell stabilizer; inhibits mast cell mediator release. Also suppresses inflammation by inhibition of cytokine production.

  • Chemical Name: Nitrendipine
    CAS No.: 39562-70-4 Purity: #99 % Appearances: light yellow to green yellow Solid
    Brand:Tocris Synonyms: Ethyl methyl 1,4-dihydro-2,... Quality Control & MSDS Files:
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    L-type calcium channel blocker.

  • Chemical Name: Nateglinide
    CAS No.: 105816-04-4 Purity: Appearances: White to off-white Solid
    Brand:Tocris Synonyms: Starlix;Fastic;Starsis;A416... Quality Control & MSDS Files:
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    K<sub>ir</sub>6 (K<sub>ATP</sub>) blocker. Exhibits <em>in vitro</em> tissue selectivity for pancreatic <span class='symbol'>&#946;</span>-cell-type K<sub>ir</sub>6 channels over cardiovascular K<sub>ir</sub>6 channels; displays high affinity for SUR1/K<sub>ir</sub>6.2 channels. Hypoglycemic agent; stimulates insulin secretion from...

  • Chemical Name: Mycophenolic acid
    CAS No.: 24280-93-1 Purity: #98 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: Mycophenolate;Myfortic; (E)... Quality Control & MSDS Files:
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    Immunosuppressive agent with antiviral and antitumor effects <em>in vitro</em> and <em>in vivo</em>. Potently inhibits inosine monophosphate dehydrogenase, thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. Reversibly inhibits proliferation of T and B lymphocytes and antibody formation.

  • Chemical Name: Loperamide hydrochloride
    CAS No.: 34552-83-5 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: Imodium; 4-(4-(4-chlorophen... Quality Control & MSDS Files:
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    High affinity <span class='symbol'>&mu;</span>-opioid receptor agonist with peripheral selectivity (K<sub>i</sub> values are 2, 48 and 1156 nM for <span class='symbol'>&mu;</span>-, <span class='symbol'>&delta;</span>- and <span class='symbol'>&kappa;</span>-opioid receptors respectively). Antidiarrhoeal and antihyperalgesic agent....

  • Chemical Name: Domperidone
    CAS No.: 57808-66-9 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: Motilium;Motillium;Motinorm... Quality Control & MSDS Files:
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    Peripheral dopamine D<sub>2</sub>-like receptor antagonist that does not readily cross the blood brain barrier. Displays gastroprokinetic and antiemetic properties; increases the frequency and duration of antral and duodenal contractions and protects from apomorphine-induced emesis (ED<sub>50</sub> values are 0.003 and 0.03 mg/kg f...

  • Chemical Name: Clonidine hydrochloride
    CAS No.: 4205-91-8 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: 2-(2,6-Dichloroanilino)-2-i... Quality Control & MSDS Files:
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    Prototypical I<sub>1</sub> imidazoline receptor ligand. <span class='symbol'>&alpha;</span><sub>2</sub>-adrenergic receptor agonist. Antihypertensive. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.

  • Chemical Name: Bupropion hydrochloride
    CAS No.: 31677-93-7 Purity: #99 % Appearances:
    Brand:Tocris Synonyms: Amfebutamone hydrochloride;... Quality Control & MSDS Files:
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    Non-selective inhibitor of dopamine and noradrenalin transporters (K<sub>i</sub> values are 1.4, 2.8 and 45 <span class='symbol'>&mu;</span>M for NET, DAT and SERT transporters respectively). Also inhibits neuronal nicotinic acetylcholine receptors. Displays antidepressant activity and augments nicotine self-administration at low d...

  • Chemical Name: ID-8
    CAS No.: 147591-46-6 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: ID 8;ID8; 1-(4-methoxypheny... Quality Control & MSDS Files:
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    ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture. IC50 Value: Target: DYRK in vitro: the combination of Wnt and ID-8 enhanced hESC replating efficiency, and colonies expressed ALP and displayed undifferentiated morphology.

  • Chemical Name: Eprosartan (mesylate)
    CAS No.: 144143-96-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 4-[[2-Butyl-5-(2-carboxy-3-... Quality Control & MSDS Files:
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    Eprosartan is a nonpeptide angiotensin II receptor antagonist with IC50 of 9.2 and 3.9 nM in rat and human adrenal cortical membranes, respectively.

  • Chemical Name: (<em>S</em>)-(+)-Rolipram
    CAS No.: 85416-73-5 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: (+)-Rolipram;(S)-Rolipram; ... Quality Control & MSDS Files:
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    Less active enantiomer of the PDE4 inhibitor <a href='dispprod.php?ItemId=1840'>rolipram</a> (Cat. No. 0905). <a href='dispprod.php?ItemId=2358'>(<em>R</em>)-(-)-Rolipram</a> (Cat. No. 1349) also available.

  • Chemical Name: D-(+)-Glucose
    CAS No.: 50-99-7 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: D-Glucose anhydrous; Dextro... Quality Control & MSDS Files:
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    Naturally occurring monosaccharide.

  • Chemical Name: Probucol
    CAS No.: 23288-49-5 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: Lorelco; 4,4'-(propane-2,2-... Quality Control & MSDS Files:
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    Antioxidant, anti-inflammatory and hypocholesterolemic agent. Inhibits atherogenesis in genetically hypercholesterolemic rabbits (Watanabe) and attenuates ischemia/reperfusion-induced cardiomyocyte apoptosis.

  • Chemical Name: Ibutilide hemifumarate
    CAS No.: 122647-32-9 Purity: #98 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: N-[4-[4-(ethyl-heptyl-amino... Quality Control & MSDS Files:
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    Class III antiarrhythmic. Blocks the rapid component of delayed rectifier K<sup>+</sup> current (I<sub>Kr</sub>); also blocks hERG channels and L-type Ca<sup>2+</sup> channels. Shown to activate a slow inward Na<sup>+</sup> current in guinea pig ventricular cells. Used to terminate atrial fibrillation and atrial flutter; can prolon...