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Tocris Bioscience Inc.

4828

Basic Information

Company Name:Tocris Bioscience Inc.

Business Type:Chemical manufacturer since 1982

Total NO.Employees:50

Country/Region:USA

Certificates:

Year Established: 1982

Introduction of Tocris Bioscience Inc.

Tocris Bioscience is the trading name of Tocris Cookson Ltd., which is headquartered in Bristol, UK. There are approximately 50 employees in the company. In May 2011 Tocris Bioscience was wholly acquired by R&D Systems, headquartered in Minneapolis, MN, USA.

Web: www.tocris.com TEL:+1 (636) 207-7651 Fax:+1 (636) 207-7683 Email:[email protected]; [email protected]

Products of Tocris Bioscience Inc.

  • Chemical Name: Ampicillin sodium salt
    CAS No.: 69-52-3 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Sodium [2S-[2alpha,5alpha,6... Quality Control & MSDS Files:
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    Antibiotic. Widely used selection reagent for transformed cells expressing β-lactamase.

  • Chemical Name: Betaxolol hydrochloride
    CAS No.: 63659-19-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 1-(Isopropylamino)-3-[4-[2-... Quality Control & MSDS Files:
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    Selective β1-adrenoceptor antagonist.

  • Chemical Name: PTC 209
    CAS No.: 315704-66-6 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: PTC209;PTC 209; N-(2,6-dibr... Quality Control & MSDS Files:
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    Bmi-1 inhibitor (IC50 ~ 0.5 μM); irreversibly impairs colorectal cancer-initiating cell (CIC) growth. Reduces tumor growth in CIC xenograft assays and results in reduced potential of colorectal cancer cells to initiate tumors in vivo.

  • Chemical Name: Medetomidine hydrochloride
    CAS No.: 86347-15-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Domitor hydrochloride;MPV78... Quality Control & MSDS Files:
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    Potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Inhibits twitch response in electrically stimulated mouse vas deferens (pD2 = 9.0). Active ...

  • Chemical Name: Mdivi 1
    CAS No.: 338967-87-6 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Mdivi 1;Mitochondrial divis... Quality Control & MSDS Files:
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    Selective inhibitor of Dnm1 GTPase (IC50 = 1 - 10 μM); attenuates Dnm1- and Drp1-mediated mitochondrial division. Inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis. Inhibits autophagy.

  • Chemical Name: Moxonidine hydrochloride
    CAS No.: 75536-04-8 Purity: Appearances:
    Brand: Synonyms: Physiotens hydrochloride;BD... Quality Control & MSDS Files:
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    Mixed I1 imidazoline receptor and α2-adrenergic agonist; displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors. Centrally acting antihypertensive agent.

  • Chemical Name: TCS JNK 5a
    CAS No.: 312917-14-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: JNK Inhibitor IX; N-(3-cyan... Quality Control & MSDS Files:
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    Selective inhibitor of JNK2 and JNK3 (pIC50 values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α respectively). Displays no significant activity at a range of other protein kinases including EGFR, ErbB2, cdk2, PLK-1 and Src (pIC50 < 5.0).

  • Chemical Name: Niclosamide
    CAS No.: 50-65-7 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: Bayluscid; 2',5-Dichloro-4'... Quality Control & MSDS Files:
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    Inhibitor of the STAT3 signaling pathway; inhibits the activation, nuclear translocation and transactivation of STAT3. Displays selectivity for STAT3 over STAT1, STAT5, JAK1, JAK2 and Src kinases. Inhibits the transcription of STAT3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with co...

  • Chemical Name: PMSF
    CAS No.: 329-98-6 Purity: #98 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: alpha-Toluenesulfonyl fluor... Quality Control & MSDS Files:
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    Non-selective protease inhibitor; irreversibly sulfonates key active site serine residues in serine proteases, acetylcholinesterases, and thiol proteases. Blocks metabolism of <a href='dispprod.php?ItemId=2338'>anandamide</a> (Cat. No. 1339) in a rodent model of cannabimimetic activity. Unstable in water (t<sub>1/2</sub> ~ 60 mins ...

  • Chemical Name: Lamotrigine
    CAS No.: 84057-84-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 6-(2,3-Dichlorophenyl)-1,2,... Quality Control & MSDS Files:
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    Anticonvulsant. Inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents. Also blocks heterologously expressed and native α4β2 nAChRs with a similar affinity to Na+ channels. Water-soluble Salt also available.

  • Chemical Name: Niflumic acid
    CAS No.: 4394-00-7 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: 2-[3-(Trifluoromethyl)anili... Quality Control & MSDS Files:
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    Nonsteroidal anti-inflammatory drug (NSAID); selectively inhibits COX-2. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35.

  • Chemical Name: Hygromycin B
    CAS No.: 31282-04-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Hygrovetine; (3aS,3'R,4S,4'... Quality Control & MSDS Files:
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    Aminoglycoside antibiotic. Active against both prokaryotic and eukaryotic cells. Inhibits protein synthesis by binding to the 30S subunit and inhibiting the ribosomal translocation step of elongation.

  • Chemical Name: TC JL 37New
    CAS No.: 1258294-34-6 Purity: Appearances:
    Brand: Synonyms: 2-chloro-4-cyano-6-fluoro-N... Quality Control & MSDS Files:
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    Potent inhibitor of tyrosine kinase 2 (TYK2, Ki = 1.6 nM). Shows some selectivity for TYK2 over JAK1/2/3. Inhibits IFNγ production in vivo in mice. Orally bioavailable.

  • Chemical Name: LB 42708
    CAS No.: 226929-39-1 Purity: Appearances:
    Brand: Synonyms: (1-((1-(4-bromobenzyl)-1H-i... Quality Control & MSDS Files:
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    Selective inhibitor of farnesyltransferase (FTase). Blocks farnesylation of H-Ras, N-Ras and K-Ras4B (IC50 values are 0.8, 1.2 and 2.0 nM respectively). Displays >50,000-fold selectivity for FTase over geranylgeranyltransferase (GGTase) I. Inhibits VEGF-induced Ras activation; suppresses angiogenesis in vivo and in vitro (IC50 = 75 nM...

  • Chemical Name: GGTI 298
    CAS No.: 1217457-86-7 Purity: Appearances:
    Brand: Synonyms: GGTI-298 TFA; GGTI-298 trif... Quality Control & MSDS Files:
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    CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor. Strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50 values are 3 and > 10 μM respectively). Causes G0-G1 cell cycle block and apoptosis in A549 cells and inhibits cell invasion and migration in CO...

  • Chemical Name: SR 11302
    CAS No.: 160162-42-5 Purity: #98 % Appearances:
    Brand:Tocris Synonyms: (2E,4E,6Z,8E)-3-methyl-7-(p... Quality Control & MSDS Files:
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    Inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects <em>in vivo</em>. Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC<sub>50</sub> &gt; 1 <span class='symbol'>&mu;</span>M for RAR<span class='symb...

  • Chemical Name: Noradrenaline bitartrate
    CAS No.: 108341-18-0 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: Noradrenaline bitartrate mo... Quality Control & MSDS Files:
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    Endogenous adrenergic hormone and neurotransmitter. A classical stress hormone; underlies the fight or flight response, along with adrenaline. Increases heart rate. Vasoconstrictor.

  • Chemical Name: Lonidamine
    CAS No.: 50264-69-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 1-(2,4-Dichlorobenzyl)-1H-i... Quality Control & MSDS Files:
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    Anticancer and antispermatogenic agent in vitro and in vivo. Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl- channels in vitro.

  • Chemical Name: Miglitol
    CAS No.: 72432-03-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Glyset;Seibule;Diastabol;BA... Quality Control & MSDS Files:
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    Inhibitor of α-glucosidase; antihyperglycemic. Suppresses postprandial hyperglycemia in vivo and reduces plasma glucose concentration in normal rats and in several animal models of diabetes. Shown to inhibit the loss of pancreatic β cells in type 2 diabetic rats. Also inhibits apoptosis and mitochondrial overproduction of reactive oxyg...

  • Chemical Name: (R)-(-)-Phenylephrine hydrochloride
    CAS No.: 61-76-7 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: L(-)-Phenylephrine hydrochl... Quality Control & MSDS Files:
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    α1-adrenoceptor agonist; pKi values are 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.