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Tocris Bioscience Inc.

4828

Basic Information

Company Name:Tocris Bioscience Inc.

Business Type:Chemical manufacturer since 1982

Total NO.Employees:50

Country/Region:USA

Certificates:

Year Established: 1982

Introduction of Tocris Bioscience Inc.

Tocris Bioscience is the trading name of Tocris Cookson Ltd., which is headquartered in Bristol, UK. There are approximately 50 employees in the company. In May 2011 Tocris Bioscience was wholly acquired by R&D Systems, headquartered in Minneapolis, MN, USA.

Web: www.tocris.com TEL:+1 (636) 207-7651 Fax:+1 (636) 207-7683 Email:[email protected]; [email protected]

Products of Tocris Bioscience Inc.

  • Chemical Name: Valdecoxib
    CAS No.: 181695-72-7 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 4-(5-Methyl-3-phenyl-1,2-ox... Quality Control & MSDS Files:
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    Selective and potent COX-2 inhibitor (in vitro IC50 values are 0.005 and 140 μM for human recombinant COX-2 and COX-1 respectively). Displays potent anti-inflammatory activity in vivo.

  • Chemical Name: SRPIN340
    CAS No.: 218156-96-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: SRPIN 340;SRPIN-340;SRPK in... Quality Control & MSDS Files:
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    SRPIN340 is a serine/arginine-rich protein kinase (SRPK)-specific inhibitor with an IC50 value of 0.89 uM (SRPK1); no significant inhibitory activity against more than 140 other kinases. IC50 Value: 0.89 uM (SRPK1) [1] Target: SRPK in vitro: SRPIN340 potently inhibits SRPK1 kinase activity, with a Kivalue of 0.89 μM.

  • Chemical Name: Verapamil (hydrochloride)
    CAS No.: 152-11-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: alpha-(3-((2-(3,4-Dimethoxy... Quality Control & MSDS Files:
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    Verapamil Hcl is an L-type calcium channel blocker of thephenylalkylamine class. IC50 Value: 0.246 ±0.013 uM (Cardiac L-Type Calcium Channel) [1] Target: L-type calcium channel It has been used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and most recently, cluster headaches. in vitro: In the K562/ADR cell...

  • Chemical Name: Angiotensin II
    CAS No.: 4474-91-3 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Asp-Arg-Val-Tyr-Ile-His-Pro... Quality Control & MSDS Files:
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    Endogenous potent vasoconstrictor peptide. Stimulates the synthesis and release of aldosterone.

  • Chemical Name: Necrostatin-1
    CAS No.: 4311-88-0 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: 5-(1H-Indol-3-ylmethyl)-3-m... Quality Control & MSDS Files:
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    Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM. IC50 Value: 490 nM (EC50) Target: TNF-alpha Necrostatin-1 is an inhibitor of necroptosis, a mechanism of programmed cell death separate from apoptosis.

  • Chemical Name: NVP 231
    CAS No.: 362003-83-6 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: NVP-231;NVP231; (3r,5r,7r)-... Quality Control & MSDS Files:
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    NVP-231 is a potent, specific, and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits binding of ceramide to CerK. IC50 Value: 12±2 nM [1] Target: CERK in vitro: NVP-231 showed an IC50 value of 12 ± 2 nM and 90% inhibition at 100 nM in the radioassay.

  • Chemical Name: 1-Naphthyl PP1
    CAS No.: 221243-82-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 1-NA-PP 1; 1-(tert-butyl)-3... Quality Control & MSDS Files:
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    Selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).

  • Chemical Name: GW 0742
    CAS No.: 317318-84-6 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: GW610742 Quality Control & MSDS Files:
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    Potent and highly selective PPARδ agonist. EC50 values are 0.001, 1.1 and 2 μM for transactivation of human PPARδ, -α, and -γ receptors respectively. Neuroprotective in rat cerebellar granule neuronal cultures after brief (12-hour) exposure but exhibits inherent toxicity after prolonged (48-hour) incubation. Increases rate of fatty aci...

  • Chemical Name: DIM
    CAS No.: 1968-05-4 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: di(1H-indol-3-yl)methane Quality Control & MSDS Files:
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    Activator of Chk2 that causes G<sub>2</sub>/M cell cycle arrest in various cancer cell lines. Antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.

  • Chemical Name: Napabucasin
    CAS No.: 83280-65-3 Purity: Appearances: Light green to green Solid
    Brand: Synonyms: BBI608 Quality Control & MSDS Files:
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    STAT3 inhibitor. Blocks spherogenesis of cancer stem cells (CSC), but not hematopoietic stem cells. Inhibits PaCa-2 xenograft tumor growth in mice, even after cessation of treatment, and decreases population of CSCs in PaCa-2 tumors from treated mice. Also blocks spleen and liver metastases of colon cancer cells in a mouse model.

  • Chemical Name: SB 269970 hydrochloride
    CAS No.: 261901-57-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: SB-269970A;SB 269970 hydroc... Quality Control & MSDS Files:
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    Potent and selective 5-HT7 receptor antagonist (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B and < 6.0 for 5-HT1A, 5-HT1D, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT4 and 5-HT6 receptors respectively). Brain penetrant in vivo.

  • Chemical Name: CGP 37157
    CAS No.: 75450-34-9 Purity: Appearances:
    Brand: Synonyms: CGP37157;CGP-37157 Quality Control & MSDS Files:
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    Selective antagonist of the mitochondrial Na+-Ca2+ exchanger (IC50 = 0.4 μM).

  • Chemical Name: Ellipticine
    CAS No.: 519-23-3 Purity: Appearances:
    Brand: Synonyms: Ellipticine; 5,11-dimethyl-... Quality Control & MSDS Files:
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    Naturally occurring plant alkaloid with antitumor activity. DNA intercalating agent; blocks DNA topoisomerase II activity. Prevents p53 phosphorylation in lung cancer cells.

  • Chemical Name: Dobutamine hydrochloride
    CAS No.: 49745-95-1 Purity: Appearances: White to off-white solid
    Brand: Synonyms: 4-[2-[[3-(4-Hydroxyphenyl)-... Quality Control & MSDS Files:
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    β1- and β2-adrenoceptor agonist with some action at the α1-adrenoceptor.

  • Chemical Name: Trifluorothymidine
    CAS No.: 70-00-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 2'-Deoxy-5-(trifluoromethyl... Quality Control & MSDS Files:
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    Trifluorothymidine (TFT) and is an inhibitor of thymidine phosphorylase.

  • Chemical Name: LY 255283
    CAS No.: 117690-79-6 Purity: Appearances:
    Brand: Synonyms: LY255283;LY-255283;CGS 2335... Quality Control & MSDS Files:
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    Selective, competitive antagonist of BLT2 receptors (IC50 values are ~ 1 and > 10 μM at human recombinant BLT2 and BLT1 receptors respectively). Inhibits LTB4-induced contraction of lung parenchyma (pA2 = 7.2), and reduces LTB4-mediated airway obstruction in guinea pigs following i.v. and oral administration..

  • Chemical Name: OTX 015
    CAS No.: 202590-98-5 Purity: Appearances: White to off-white solid
    Brand: Synonyms: OTX 015;OTX015; (S)-2-(4-(4... Quality Control & MSDS Files:
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    BET bromodomain inhibitor (IC50 values are in the range 92 - 112 nM). Inhibits proliferation and induces apoptosis of leukemia cell lines in vitro. Decreases BRD2, BRD4 and c-MYC protein expression. Orally bioavailable.

  • Chemical Name: HA 1100 hydrochloride
    CAS No.: 155558-32-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: HA-1100 hydrochloride;HA 11... Quality Control & MSDS Files:
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    Cell-permeable active metabolite of Fasudil (HA 1077; Cat. No. 0541). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo.

  • Chemical Name: Sildenafil citrate
    CAS No.: 171599-83-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 1-[[3-(6,7-Dihydro-1-methyl... Quality Control & MSDS Files:
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    Orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro.

  • Chemical Name: NS 398
    CAS No.: 123653-11-2 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: N-(2-Cyclohexyloxy-4-nitrop... Quality Control & MSDS Files:
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    Selective cyclooxygenase-2 inhibitor (IC50 values are 3.8 and > 100 μM for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro. Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo.

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