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Tocris Bioscience Inc.

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Basic Information

Company Name:Tocris Bioscience Inc.

Business Type:Chemical manufacturer since 1982

Total NO.Employees:50

Country/Region:USA

Certificates:

Year Established: 1982

Introduction of Tocris Bioscience Inc.

Tocris Bioscience is the trading name of Tocris Cookson Ltd., which is headquartered in Bristol, UK. There are approximately 50 employees in the company. In May 2011 Tocris Bioscience was wholly acquired by R&D Systems, headquartered in Minneapolis, MN, USA.

Web: www.tocris.com TEL:+1 (636) 207-7651 Fax:+1 (636) 207-7683 Email:[email protected]; [email protected]

Products of Tocris Bioscience Inc.

  • Chemical Name: (+)-Bicuculline
    CAS No.: 485-49-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (R-(R*,S*))-6-(5,6,7,8-Tetr... Quality Control & MSDS Files:
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  • Chemical Name: Cantharidin
    CAS No.: 56-25-7 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Dimethyl-3,6-epoxyperhydrop... Quality Control & MSDS Files:
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    Brown to black powder or plates or scales. Formerly used as a counterirritant and vesicant. Used for the removal of warts. Used as an experimental anti tumor agent. Active ingredient in spanish fly, a reputed aphrodisiac.

  • Chemical Name: Icatibant
    CAS No.: 130308-48-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (S)-2-((2S,3aS,7aS)-1-((R)-... Quality Control & MSDS Files:
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  • Chemical Name: Tesaglitazar
    CAS No.: 251565-85-2 Purity: #98 % Appearances:
    Brand:Tocris Synonyms: AR-H 039242;AR-H 039242XX;A... Quality Control & MSDS Files:
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    Dual-specificity PPAR<span class='symbol'>&#945;</span>/<span class='symbol'>&#947;</span> agonist (IC<sub>50</sub> values are 0.35 and 3.8 <span class='symbol'>&#956;</span>M for PPAR<span class='symbol'>&#947;</span> and PPAR<span class='symbol'>&#945;</span> respectively). Prevents atherosclerosis progression in E3L.CETP transge...

  • Chemical Name: Sivelestat
    CAS No.: 127373-66-4 Purity: Appearances:
    Brand: Synonyms: N-(2-(((4-(2,2-Dimethyl-1-o... Quality Control & MSDS Files:
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    Sivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse. IC50 value: 44 nM [1] Target: neutrophil elastase ONO-5046 did not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kal...

  • Chemical Name: P 22077
    CAS No.: 1247819-59-5 Purity: #99 % Appearances: Light yellow to yellow Solid
    Brand:Tocris Synonyms: P22077;P-22077; 1-(5-((2,4-... Quality Control & MSDS Files:
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    Inhibitor of ubiquitin-specific protease (USP) 7 (EC<sub>50</sub> = 8.6 <span class='symbol'>&#956;</span>M); also inhibits the closely related deubiquitinase (DUB) USP47. Demonstrates downstream inhibition of HDM2 and claspin <em>in vitro</em>. Inhibits USP7-mediated p53 deubiquitination. Blocks deubiquitination of Tip60 (KAT5) hi...

  • Chemical Name: Hydroxy Dynasore
    CAS No.: 1256493-34-1 Purity: #98 % Appearances:
    Brand:Tocris Synonyms: Quality Control & MSDS Files:
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    Dynamin inhibitor (IC<sub>50</sub> values are 0.38 and 2.6 <span class='symbol'>&#956;</span>M for dynamin 1 and 2 respectively). Inhibits dynamin-mediated endocytosis in multiple cell types and reduces synaptic vesicle endocytosis <em>in vitro</em>. Prevents botulinum A internalization in hippocampal neurons. Also protects against...

  • Chemical Name: Zolpidem
    CAS No.: 82626-48-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: N,N,6-Trimethyl-2-(4-methyl... Quality Control & MSDS Files:
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    Zolpideman(SL 800750) is an inhibitory neurotransmitter, by binding to GABAA receptors at the same location as benzodiazepines. IC50 Value: 75 nM (EC50)[1] Target: GABAA receptor in vitro: All granule cell GABAR currents were uniformly sensitive to Zn2+ (IC50 = 29 microM), diazepam (EC50 = 158 nM), zolpidem (EC50 = 75 nM), and dimet...

  • Chemical Name: GKA 50
    CAS No.: 851884-87-2 Purity: #98 % Appearances:
    Brand:Tocris Synonyms: GKA50;GKA-50; 6-(3-(((S)-1-... Quality Control & MSDS Files:
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    Potent glucokinase activator (EC<sub>50</sub> = 33 nM). Significantly reduces plasma glucose levels in diabetic rats; stimulates insulin release from mouse islets of Langerhans.

  • Chemical Name: GW 7647
    CAS No.: 265129-71-3 Purity: #99 % Appearances: white
    Brand:Tocris Synonyms: GW 7647; GW 7647X; 2-((4-(2... Quality Control & MSDS Files:
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    Potent and highly selective PPAR<span class='symbol'>&#945;</span> agonist (EC<sub>50</sub> values are 6, 1100 and 6200 nM for human PPAR<span class='symbol'>&alpha;</span>, PPAR<span class='symbol'>&gamma;</span> and PPAR<span class='symbol'>&delta;</span> receptors respectively). Modulates oleate metabolism and mitochondrial enzy...

  • Chemical Name: P005091
    CAS No.: 882257-11-6 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: P5091;P-005091;P 005091;P 5... Quality Control & MSDS Files:
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    P005091(P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.

  • Chemical Name: ERK5-IN-1
    CAS No.: 1435488-37-1 Purity: #98 % Appearances: Light yellow to yellow Solid
    Brand:Tocris Synonyms: XMD17 109; 11-cyclopentyl-2... Quality Control & MSDS Files:
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    Potent and selective ERK5 inhibitor; inhibits EGFR-induced ERK5 autophosphorylation (EC<sub>50</sub> = 90 nM) and ERK5 enzymatic activity (IC<sub>50</sub> = 162 nM). Exhibits at least 30-fold selectivity for ERK5 over LRRK2 in a cell based assay. Also selective for ERK5 over a panel of other kinases. Orally bioavailable. </div> ...

  • Chemical Name: IPA-3
    CAS No.: 42521-82-4 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: IPA 3;IPA3; 1,1'-disulfaned... Quality Control & MSDS Files:
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    IPA-3 is a selective non-ATP competitive PAK1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6). IC50 Value: 2.5uM; 1.92 ± 0.2 μM( Dissociation constant) [1] Target: PAK1 in vitro: Saturable binding of IPA-3 to full-length Pak1 was observed with an apparent dissociation constant of 1.92 ± 0.2 μM, consistent wi...

  • Chemical Name: TC-S 7009
    CAS No.: 1422955-31-4 Purity: #99 % Appearances:
    Brand:Tocris Synonyms: N-(3-chloro-5-fluorophenyl)... Quality Control & MSDS Files:
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    High affinity and selective HIF-2<span class='symbol'>&#945;</span> inhibitor (K<sub>d</sub> = 81 nM). Binds to the HIF-2<span class='symbol'>&#945;</span> PAS-B domain; disrupts HIF-2<span class='symbol'>&#945;</span>-ARNT heterodimerization. Exhibits &#062;60-fold selectivity for HIF-2<span class='symbol'>&#945;</span> over HIF-1...

  • Chemical Name: C646
    CAS No.: 328968-36-1 Purity: Appearances: Pale brown to red brown Solid
    Brand: Synonyms: C 646; (E)-4-(4-((5-(4,5-di... Quality Control & MSDS Files:
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    C646 is a selective and competitive <b>histone acetyltransferase p300</b> inhibitor with <b>K<sub>i</sub></b> of 400 nM, and is less potent for other acetyltransferases.

  • Chemical Name: SKI II
    CAS No.: 312636-16-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: SphK-I2; 4-((4-(4-chlorophe... Quality Control & MSDS Files:
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  • Chemical Name: Stattic
    CAS No.: 19983-44-9 Purity: Appearances:
    Brand: Synonyms: 6-Nitrobenzo[b]thiophene 1,... Quality Control & MSDS Files:
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    Stattic is a potent inhibitor of <b>STAT3</b>, used for cancer treatment.

  • Chemical Name: IU1
    CAS No.: 314245-33-5 Purity: #98 % Appearances:
    Brand:Tocris Synonyms: 1-(1-(4-fluorophenyl)-2,5-d... Quality Control & MSDS Files:
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    Selective inhibitor of Usp14; inhibits the catalytic activity of proteasome-associated Usp14 <em>in vitro</em> (IC<sub>50</sub> &#60; 4 <span class='symbol'>&#956;</span>M). Stimulates proteasome activity and substrate degradation.

  • Chemical Name: KY02111
    CAS No.: 1118807-13-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: KY 02111;KY-02111; N-(6-chl... Quality Control & MSDS Files:
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    KY02111 is a small molecule which can promote differentiation of hPSCs to cardiomyocytes. IC50 value: Target: Wnt signaling inhibitor KY02111 Induces downregulation of Wnt signaling target genes; inhibits canonical Wnt signaling in a manner distinct from other known Wnt inhibitors. KY02111 (10 μM) increases the ratio of beating ca...

  • Chemical Name: PR-619
    CAS No.: 2645-32-1 Purity: Appearances: light yellow to khaki Solid
    Brand: Synonyms: PR 619; 3,5-dithiocyanatopy... Quality Control & MSDS Files:
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    PR-619 is a broad-range DUB inhibitor with potential for further development as a chemotherapeutic agent in cancer therapy.

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