• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

Tocris Bioscience Inc.

2800

Basic Information

Company Name:Tocris Bioscience Inc.

Business Type:Chemical manufacturer since 1982

Total NO.Employees:50

Country/Region:USA

Certificates:

Year Established: 1982

Introduction of Tocris Bioscience Inc.

Tocris Bioscience is the trading name of Tocris Cookson Ltd., which is headquartered in Bristol, UK. There are approximately 50 employees in the company. In May 2011 Tocris Bioscience was wholly acquired by R&D Systems, headquartered in Minneapolis, MN, USA.

Web: www.tocris.com TEL:+1 (636) 207-7651 Fax:+1 (636) 207-7683 Email:[email protected]; [email protected]

Products of Tocris Bioscience Inc.

  • Chemical Name: iCRT 14
    CAS No.: 677331-12-3 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: iCRT14;iCRT-14; (Z)-5-((2,5... Quality Control & MSDS Files:
    Price and Availability:
    Brief introduction:

    iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). IC50 value: 40.3 nM [1] Target: Wnt inhibitor Thought to directly influence the interaction between β-catenin and TCF4.

  • Chemical Name: SJ-172550
    CAS No.: 431979-47-4 Purity: Appearances: Pink to red Solid
    Brand: Synonyms: SJ172550;SJ 172550; (E)-met... Quality Control & MSDS Files:
    Price and Availability:
    Brief introduction:

    SJ-172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. IC50 value: 0.84 uM(EC50) [1] Target: MDMX inhibitor in vitro: Unlike SJ-134433 and SJ-044557, SJ-172550 was stable in solution and did not modify the MDMX prot...

  • Chemical Name: ITX3
    CAS No.: 347323-96-0 Purity: Appearances:
    Brand: Synonyms: ITX 3;ITX-3; (E)-2-((2,5-di... Quality Control & MSDS Files:
    Price and Availability:
    Brief introduction:

    ITX3 is a specific and nontoxic inhibitor of the TrioN (N-terminal GEF domain of the multidomain Trio protein) with IC50 of 76 uM; inhibits TrioN-stimulated RhoG exchange in vitro. IC50 value: 76 uM [1] Target: TrioN inhibitor In transfected mammalian cells, ITX3 blocked TrioN-mediated dorsal membrane ruffling and Rac1 activation w...

  • Chemical Name: DMH-1
    CAS No.: 1206711-16-1 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: DMH1;DMH 1; 4-(6-(4-isoprop... Quality Control & MSDS Files:
    Price and Availability:
    Brief introduction:

    DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/<5 nM for ALK1/2/3 respectively; inactive on ALK5, BMPR2, AMPK and VEGFR2. IC50 value: 27/107.9/<5 nM(ALK1/2/3) [1] Target: ALK inhibitor DMH-1 shows the most selectivity within these three compounds(LDN-193189, DMH-1 and dorsomorphin) [1].

  • Chemical Name: Oncrasin-1
    CAS No.: 75629-57-1 Purity: Appearances: Light yellow to earth yellow Solid
    Brand: Synonyms: Oncrasin 1;Oncrasin1; 1-(4-... Quality Control & MSDS Files:
    Price and Availability:
    Brief introduction:

    Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations; also led to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells. IC50 value: 1.0 μM(A549, K-ras 12H and p53 Wt) [1] Target: human lung can...

  • Chemical Name: Skp2 Inhibitor C1
    CAS No.: 432001-69-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: SKPin C1; (Z)-2-(4-bromo-2-... Quality Control & MSDS Files:
    Price and Availability:
    Brief introduction:

    Skp2 Inhibitor C1(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation, selectively inhibited Skp2-mediated p27 degradation by reducing p27binding through key compound-receptor contacts. IC50 value: Target: Skp2 inhibitor; p27 regulator in vitro: T47D cells treated with C1 (5 μM for 16 hours) displayed ...

  • Chemical Name: INH1
    CAS No.: 313553-47-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: IBT13131; N-(4-(2,4-dimethy... Quality Control & MSDS Files:
    Price and Availability:
    Brief introduction:

    INH1 is a small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. IC50 value: 10-21 uM (GI50 in human breast cancer cell lines) [1] Target: Hec1 inhibitor Treating cells with INH1 triggered reduction of kinetochore-bound Hec1 as well as global Nek2 protein level, consequently lea...

  • Chemical Name: EHT 1864
    CAS No.: 754240-09-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: EHT1864;EHT-1864; 2-(morpho... Quality Control & MSDS Files:
    Price and Availability:
    Brief introduction:

    EHT 1864 is a small molecule inhibitor of Rac1 signaling; modulate γ-Secretase-mediated APP processing. IC50 value: Target: Rac1 inhibitor in vitro: EHT 1864 blocks Aβ 40 and Aβ 42 production but does not impact sAPPα levels and does not inhibit γ-secretase.

  • Chemical Name: Z-VAD(OMe)-FMK
    CAS No.: 187389-52-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Z-Val-Ala-Asp(OMe)-FMK Quality Control & MSDS Files:
    Price and Availability:
    Brief introduction:

    Z-VAD(OMe)-FMK is a cell-permeable, <b>pan-caspase</b> inhibitor.

  • Chemical Name: Melphalan
    CAS No.: 148-82-3 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 4-[Bis(2-chloroethyl)amino]... Quality Control & MSDS Files:
    Price and Availability:
    Brief introduction:

    Melphalan(Sarcolysin; L-PAM) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents; attaches the alkyl group to the guanine base of DNA. IC50 value: Target: DNA alkylator The agent was first investigated as a possible drug for use in melanoma.

  • Chemical Name: SB 366791
    CAS No.: 472981-92-3 Purity: Appearances: off-white
    Brand: Synonyms: SB366791;SB-366791; 3-(4-ch... Quality Control & MSDS Files:
    Price and Availability:
    Brief introduction:

  • Chemical Name: Carbetocin
    CAS No.: 37025-55-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (S)-1-((3R,6S,9S,12S,15S)-6... Quality Control & MSDS Files:
    Price and Availability:
    Brief introduction:

    Carbetocin (Lonactene; Duratocin) is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth; an agonist at peripheral oxytocin receptors.

  • Chemical Name: Oxytocin
    CAS No.: 50-56-6 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (2S)-1-[(4R,7S,10S,13S,16S,... Quality Control & MSDS Files:
    Price and Availability:
    Brief introduction:

    Oxytocin (α-Hypophamine) is a mammalian neurohypophysial hormone; its actions are mediated by specific, high-affinity oxytocin receptors; ligand of oxytocin receptor.

  • Chemical Name: GBR 12935 (dihydrochloride)
    CAS No.: 67469-81-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: GBR12935 dihydrochloride;GB... Quality Control & MSDS Files:
    Price and Availability:
    Brief introduction:

    GBR 12935 2Hcl is a potent, and selective dopamine reuptake inhibitor. IC50 value: Target: dopamine reuptake inhibitor in vitro: The calculated Kd of [3H]GBR-12935 binding to CYP2D6 was 42.2 nM, indicating that GBR-12935 has a high affinity for CYP2D6.

  • Chemical Name: Palbociclib (isethionate)
    CAS No.: 827022-33-3 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: PD0332991 isethionate;PD-03... Quality Control & MSDS Files:
    Price and Availability:
    Brief introduction:

    Palbociclib isethionate(PD-0332991 isethionate) is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases. IC50 value: 11 nM/16 nM (Cdk4/Cdk6) [1] Target: Cdk4/Cdk6 in vitro: ATP competitive inhibitor of Cdk4.

  • Chemical Name: CID755673
    CAS No.: 521937-07-5 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: CID 755673;CID-755673; 7-hy... Quality Control & MSDS Files:
    Price and Availability:
    Brief introduction:

    CID755673 is a potent and selective cell-active small molecule inhibitor for PKD with an IC50 of 182 nM; exhibits selective PKD1 inhibition when compared with AKT, PLK1, CAK, CAMKIIα, and PKC isoforms. IC50 value: 182 nM [1] Target: PKD in vitro: In cell-based assays, CID755673 blocked phorbol ester-induced endogenous PKD1 activatio...

  • Chemical Name: IWR-1
    CAS No.: 1127442-82-3 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: endo-IWR 1;IWR-1-endo;IWR1;... Quality Control & MSDS Files:
    Price and Availability:
    Brief introduction:

    IWR-1(IWR-1-endo) is a novel small molecule Wnt signaling by stabilizing the Axin destruction complex with an EC50 of 0.2 uM. IC50 value: 0.2 uM (EC50) [1] Target: Wnt signaling During NSPC differentiation, MIF increased the activity of β-galactosidase that responds to Wnt/β-catenin signaling.

  • Chemical Name: SKF 38393 hydrobromide
    CAS No.: 20012-10-6 Purity: #99 % Appearances:
    Brand:Tocris Synonyms: SKF38393 (hydrobromide);SKF... Quality Control & MSDS Files:
    Price and Availability:
    Brief introduction:

    Prototypical D<sub>1</sub>-like dopamine receptor selective partial agonist (K<sub>i</sub> values are 1, ~ 0.5, ~ 150, ~ 5000 and ~ 1000 nM for D<sub>1</sub>, D<sub>5</sub>, D<sub>2</sub>, D<sub>3</sub> and D<sub>4</sub> receptors respectively).

  • Chemical Name: SKF 81297 hydrobromide
    CAS No.: 67287-39-2 Purity: #98 % Appearances:
    Brand:Tocris Synonyms: SKF81297 (hydrobromide);SKF... Quality Control & MSDS Files:
    Price and Availability:
    Brief introduction:

    Dopamine D<sub>1</sub>-like receptor agonist. Centrally active following systemic administration <em>in vivo</em>.

  • Chemical Name: PF-06463922
    CAS No.: 1454846-35-5 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: PF 06463922;PF 06463922; Quality Control & MSDS Files:
    Price and Availability:
    Brief introduction:

    PF-06463922 is a potent, dual <b>ALK/ROS1</b> inhibitor, with <b>K<sub>i</sub></b> of < 0.02 nM, < 0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.