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Tocris Bioscience Inc.

4828

Basic Information

Company Name:Tocris Bioscience Inc.

Business Type:Chemical manufacturer since 1982

Total NO.Employees:50

Country/Region:USA

Certificates:

Year Established: 1982

Introduction of Tocris Bioscience Inc.

Tocris Bioscience is the trading name of Tocris Cookson Ltd., which is headquartered in Bristol, UK. There are approximately 50 employees in the company. In May 2011 Tocris Bioscience was wholly acquired by R&D Systems, headquartered in Minneapolis, MN, USA.

Web: www.tocris.com TEL:+1 (636) 207-7651 Fax:+1 (636) 207-7683 Email:[email protected]; [email protected]

Products of Tocris Bioscience Inc.

  • Chemical Name: CFTRinh 172
    CAS No.: 307510-92-5 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: CFTR Inhibitor-172;CFTRinh-... Quality Control & MSDS Files:
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    Voltage-independent, selective CFTR chloride channel blocker (Ki = 300 nM) that alters channel gating. Blocks intestinal fluid secretion induced by cholera toxin and Escherichia coli and suppresses cyst growth in animal models of polycystic kidney disease. Orally active. Inhibits mitochondrial respiration and increases reactive oxygen ...

  • Chemical Name: HLM006474
    CAS No.: 353519-63-8 Purity: Appearances:
    Brand: Synonyms: HLM 006474;HLM-006474; 7-((... Quality Control & MSDS Files:
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    HLM006474 is a potent inhibitor of melanocytes proliferation and subsequent invasion in a three-dimensional tissue culture model system; interferes with E2F activity. IC50 value: 29.8 μM(EC50 in vivo) Target: E2F inhibitor in vivo: HLM006474 is not specific to E2F4 and appears to inhibit binding by all E2F complexes.

  • Chemical Name: iCRT 14
    CAS No.: 677331-12-3 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: iCRT14;iCRT-14; (Z)-5-((2,5... Quality Control & MSDS Files:
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    Potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between β-catenin and TCF4. Induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.

  • Chemical Name: SJ 172550
    CAS No.: 431979-47-4 Purity: Appearances: Pink to red Solid
    Brand: Synonyms: SJ172550;SJ 172550; (E)-met... Quality Control & MSDS Files:
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    MDMX inhibitor. Reversibly binds MDMX (EC50 = 2.3 μM). Inhibits the MDMX-p53 interaction in cultured retinoblastoma cells; frees p53 to induce apoptosis.

  • Chemical Name: ITX 3
    CAS No.: 347323-96-0 Purity: Appearances:
    Brand: Synonyms: ITX 3;ITX-3; (E)-2-((2,5-di... Quality Control & MSDS Files:
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    Selective inhibitor of TrioN RhoGEF activity. Inhibits TrioN-mediated GTP exchange on RhoG and Rac1, formation of TrioN-induced cellular structures in REF52 fibroblasts and NGF-mediated neurite outgrowth in PC12 cells in vitro.

  • Chemical Name: DMH-1
    CAS No.: 1206711-16-1 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: DMH1;DMH 1; 4-(6-(4-isoprop... Quality Control & MSDS Files:
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    Selective inhibitor of the bone morphogenic protein (BMP) ALK2 receptor (IC50 = 108 nM). Exhibits no detectable inhibition of AMPK, ALK5, KDR (VEGFR-2) or PDGFRβ receptors. Blocks BMP4-induced phosphorylation of Smads 1, 5 and 8 in HEK293 cells. Promotes neurogenesis in human induced pluripotent stem cells (iPSCs) when used in combinat...

  • Chemical Name: Oncrasin-1
    CAS No.: 75629-57-1 Purity: Appearances: Light yellow to earth yellow Solid
    Brand: Synonyms: Oncrasin 1;Oncrasin1; 1-(4-... Quality Control & MSDS Files:
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    Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations; also led to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells. IC50 value: 1.0 μM(A549, K-ras 12H and p53 Wt) [1] Target: human lung can...

  • Chemical Name: SKPin C1
    CAS No.: 432001-69-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: SKPin C1; (Z)-2-(4-bromo-2-... Quality Control & MSDS Files:
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    Inhibitor of Skp2-mediated p27 degradation. Induces p27 accumulation in metastatic melanoma cell lines. Promotes G1/S cell cycle arrest in T47D cells and LNCaP cells; induces G2/M cell cycle arrest in MCF-7 cells.

  • Chemical Name: INH1
    CAS No.: 313553-47-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: IBT13131; N-(4-(2,4-dimethy... Quality Control & MSDS Files:
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    INH1 is a small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. IC50 value: 10-21 uM (GI50 in human breast cancer cell lines) [1] Target: Hec1 inhibitor Treating cells with INH1 triggered reduction of kinetochore-bound Hec1 as well as global Nek2 protein level, consequently lea...

  • Chemical Name: EHT 1864
    CAS No.: 754240-09-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: EHT1864;EHT-1864; 2-(morpho... Quality Control & MSDS Files:
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    Inhibitor of Rac family GTPases. Blocks activation by direct binding to Rac1, Rac1b, Rac2 and Rac3 (KD values are 40, 50, 60 and 250 nM respectively). Inhibits Rac, Ras and Tiam-induced growth transformation of NIH-3T3 fibroblasts. Reduces β-amyloid peptide production in vivo.

  • Chemical Name: Z-VAD-FMK
    CAS No.: 187389-52-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Z-Val-Ala-Asp(OMe)-FMK Quality Control & MSDS Files:
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    Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.

  • Chemical Name: Melphalan
    CAS No.: 148-82-3 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 4-[Bis(2-chloroethyl)amino]... Quality Control & MSDS Files:
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    Melphalan(Sarcolysin; L-PAM) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents; attaches the alkyl group to the guanine base of DNA. IC50 value: Target: DNA alkylator The agent was first investigated as a possible drug for use in melanoma.

  • Chemical Name: XEN 445
    CAS No.: 1515856-92-4 Purity: Appearances: nigger-brown Solid
    Brand: Synonyms: XEN 445;XEN-445; (S)-2-(3-(... Quality Control & MSDS Files:
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    Selective endothelial lipase (EL) inhibitor (IC50 = 237 nM for human EL). Exhibits >20-fold selectivity for EL over lipoprotein lipase (LPL) and hepatic lipase (HL). Increases high density lipoprotein cholesterol (HDLc) plasma levels in mice. Orally bioavailable.

  • Chemical Name: SB 366791
    CAS No.: 472981-92-3 Purity: Appearances: off-white
    Brand: Synonyms: SB366791;SB-366791; 3-(4-ch... Quality Control & MSDS Files:
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  • Chemical Name: Carbetocin
    CAS No.: 37025-55-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (S)-1-((3R,6S,9S,12S,15S)-6... Quality Control & MSDS Files:
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    Oxytocin analog. Long-acting; displays agonist properties.

  • Chemical Name: AtosibanNew
    CAS No.: 90779-69-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Tractocile;Antocin;RW22164;... Quality Control & MSDS Files:
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    Potent oxytocin receptor (OTR) antagonist. Inhibits oxytocin-induced increase in Ca2+ concentration in myometrial cells in vitro (IC50 = 5 nM) Activates NF-κB and MAPK pathways in human amnion via Gαi signaling, resulting in pro-inflammatory effects. Inhibits oxytocin-induced uterine contractions in vivo and in vitro. Effective in a ra...

  • Chemical Name: Oxytocin
    CAS No.: 50-56-6 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (2S)-1-[(4R,7S,10S,13S,16S,... Quality Control & MSDS Files:
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    Neurohypophyseal peptide. Stimulates uterine contraction and lactation.

  • Chemical Name: GBR 12935 dihydrochloride
    CAS No.: 67469-81-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: GBR12935 dihydrochloride;GB... Quality Control & MSDS Files:
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    Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes).

  • Chemical Name: TAPI 1
    CAS No.: 163847-77-6 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: TAPI 1;TAPI1; (R)-N1-((S)-1... Quality Control & MSDS Files:
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    TACE/ADAM-17 and MMP inhibitor. Blocks shedding of TNF from cell membranes. Reduces pain-associated behavior in mice with a constructive mononeuropathy.

  • Chemical Name: PD 0332991 isethionate
    CAS No.: 827022-33-3 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: PD0332991 isethionate;PD-03... Quality Control & MSDS Files:
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    Potent Cdk4/6 inhibitor (IC50 values are 11 and 15 nM for Cdk4 and Cdk6 respectively). Selective for Cdk4/6 over a panel of 34 additional protein kinases (IC50 values are > 10 μM). Induces G1 cell cycle arrest and senescence in retinoblastoma protein (Rb)-proficient cell lines; blocks growth of intracranial glioblastoma multiforme xeno...